Researchers turn one form of adult mouse cell directly into another

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In this immunofluorescent image of an adult mouse pancreas exocrine cells into which three transcription factors have been inserted are displayed in green. The red areas in the image are insulin. The blue streaks are blood vessels which are remodeled ...
In this immunofluorescent image of an adult mouse pancreas, exocrine cells into which three transcription factors have been inserted are displayed in green. The red areas in the image are insulin. The blue streaks are blood vessels, which are remodeled by and lie close to the new, insulin-producing beta cells. Image courtesy Joe Zhou, Melton Lab
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(PhysOrg.com) -- In a feat of biological prestidigitation likely to turn the field of regenerative medicine on its head, Harvard Stem Cell Institute (HSCI) co-director Doug Melton and post doctoral fellow Qiao "Joe" Zhou report having achieved what has long been a dream and ultimate goal of developmental biologists – directly turning one type of fully formed adult cell into another type of adult cell.


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