Evidence of rapid evolution is found at the tips of chromosomes

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Chromosomes gone to POT. When the genes for the two POT proteins POT1a and POT1b are removed from mice telomeres dont function properly frequently resulting in endoreduplication when chromosomes are doubled at inappropriate times (left) and more rare ...
Chromosomes gone to POT. When the genes for the two POT proteins, POT1a and POT1b, are removed from mice, telomeres don’t function properly, frequently resulting in endoreduplication, when chromosomes are doubled at inappropriate times (left), and, more rarely, chromosome fusions (right).

In terms of their telomeres, mice are more complicated than humans. That’s the finding from a recent Rockefeller University study, which shows that mice have two proteins working together to do the job of a single protein in human cells. The findings, published recently in Cell, suggest that the protein complex that protects chromosome ends may have evolved far more rapidly than previously believed.


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