Central and peripheral signals set the circadian liver clock

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System-driven circadian gene expression -- A link between the central and local oscillators. Credit: Schibler et al.
System-driven circadian gene expression -- A link between the central and local oscillators. Credit: Schibler et al.

Anyone who has experienced jet lag will understand the importance of a smooth-running circadian clock. Crossing time zones decouples our biological rhythms from the natural cycle of light and dark we’re used to. We perceive light cues through retinal photoreceptors that relay signals to the suprachiasmatic nucleus (SCN) in the brain. "Phase adjustments" in peripheral tissues ensure that each clock follows the same schedule.


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