Review of 1918 pandemic flu studies offers more questions than answers

Scientists and public health officials, wary that the H5N1 avian influenza virus could trigger an influenza pandemic, have looked to past pandemics, including the 1918 "Spanish Flu," for insight into pandemic planning. However, in a Journal of Infectious Diseases review article now posted online, David M. Morens, M.D., and Anthony S. Fauci, M.D., of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, conclude that studies of the 1918 influenza pandemic, which killed some 50 to 100 million people around the globe, have so far raised more questions than they answer.