'Mighty mice' made mightier

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Comparison of body and muscle size between normal (left) and double mutant mice lacking myostatin and overproducing follistatin (right). Credit: Se-Jin lee
Comparison of body and muscle size between normal (left) and double mutant mice lacking myostatin and overproducing follistatin (right). Credit: Se-Jin lee

The Johns Hopkins scientist who first showed that the absence of the protein myostatin leads to oversized muscles in mice and men has now found a second protein, follistatin, whose overproduction in mice lacking myostatin doubles the muscle-building effect.


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