Role of a key enzyme in reducing heart disease identified

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A macrophage foam cell contained fat droplets (green) that are surrounded by CEH (red) showing how this enzyme associates with fat and releases cholesterol to be picked up by HDL. The nucleus of the cell is stained blue. Credit: Bernard J. FisherVCU
A macrophage foam cell contained fat droplets (green) that are surrounded by CEH (red) showing how this enzyme associates with fat and releases cholesterol to be picked up by HDL. The nucleus of the cell is stained blue. Credit: Bernard J. Fisher/VCU

Virginia Commonwealth University researchers have identified the role of a key enzyme called CEH in reducing heart disease, paving the way for new target therapies to reduce plaques in the arteries and perhaps in the future, help predict a patient’s susceptibility to heart disease.


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