Active mechanism locks in the size of a cell's nucleus

Cells know that size matters, especially when it comes to the nucleus. In the early 1900s, German scientists first proposed that the size of a nucleus is always proportional to the size of its cell. Now, more than a century later, researchers at Rockefeller University show that an active mechanism controls this process. This mechanism, however, doesn’t reside within the nucleus as many once thought, but instead comes from the cell’s cytoplasm.