New picture of HIV-1's protein jacket identifies target for antibody-based vaccine

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A schematic of the HIV-1 surface protein gp41 and the membrane proximal ectodomain region (MPER). Credit: Steve Moskowitz
A schematic of the HIV-1 surface protein gp41 and the membrane proximal ectodomain region (MPER). Credit: Steve Moskowitz

By coaxing the HIV-1 protein to reveal a hidden portion of its protein coat, scientists at Dana-Farber Cancer Institute and Harvard Medical School have provided a newly detailed picture of how protective, or so-called broadly neutralizing, antibodies block HIV-1 infection.


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