Penn researchers discover new target for preventing and treating flu

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Structure of amantadine inside viral binding site. Credit: William F. DeGrado PhD University of Pennsylvania School of Medicine
Structure of amantadine inside viral binding site. Credit: William F. DeGrado, PhD, University of Pennsylvania School of Medicine

Emerging subtypes of influenza A virus hold the potential to initiate a world-wide epidemic in the next few years, according to World Health Organization officials. However, almost all type A influenza viral strains have become resistant to amantadine and rimantadine, two drugs that make up one of only two classes used to treat the flu.


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