Scientists report first 3-D view of anti-cancer agent

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The image shows bleomycin represented in a space-filling rendering bound to DNA in a gray ball-and-stick rendering. The color scheme highlights the different moieties that make up bleomycin: blue bithiazole red linker yellow metal-binding domain purp ...
The image shows bleomycin represented in a space-filling rendering bound to DNA, in a gray ball-and-stick rendering. The color scheme highlights the different moieties that make up bleomycin: blue, bithiazole; red, linker; yellow, metal-binding domain; purple, dissacharide; and green, Co (III). Credit: Kristie Goodwin, Ph.D., Indiana University School of Medicine

Researchers from the Indiana University School of Medicine and the Purdue School of Science at Indiana University-Purdue University Indianapolis have created the first three-dimensional image of how a well-established chemotherapy agent targets and binds to DNA. The study, which publishes online the week of March 17 in the Early Edition of the Proceedings of the National Academy of Sciences, may help scientists develop better chemotherapy drugs to treat a wide range of cancers.


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