Scientists determine drug target for the most potent botulinum neurotoxin

Botulinum neurotoxin – responsible for the deadly food poisoning disease botulism and for the beneficial effects of smoothing out facial wrinkles – can also be used as a dreaded biological weapon. When ingested or inhaled, less than a billionth of an ounce can cause muscle paralysis and eventual death. Although experimental vaccines administered prior to exposure can inhibit the destructive action of this neurotoxin – the most deadly protein known to humans – no effective pharmacological treatment exists.