Researchers witness assembly of molecules critical to protein function

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Depicted is a molecular representation of a four iron- four sulfur cluster in which the sulfur is shown in yellow and iron in green. Credit: Callie Raulfs
Depicted is a molecular representation of a four iron- four sulfur cluster in which the sulfur is shown in yellow and iron in green. Credit: Callie Raulfs

A Virginia Tech research group lead by two biochemistry graduate students has isolated proteins responsible for the iron-sulfur cluster assembly process and witnessed the necessary protein interactions in vivo – within a cell. They have captured pathway intermediates and observed protein interactions between the two major players in iron-sulfur cluster assembly.


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