NIST Trumps the Clumps: Making Biologic Drugs Safer

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NIST researchers have developed methods and adapted techniques that will allow the pharmaceutical industry to monitor the formation of potentially dangerous aggregates in protein-based drugs. Image Copyright: IoanaDrutu
NIST researchers have developed methods and adapted techniques that will allow the pharmaceutical industry to monitor the formation of potentially dangerous aggregates in protein-based drugs. Image Copyright: IoanaDrutu

Scientists at the National Institute of Standards and Technology have developed a technique to measure the formation of clumps of proteins in protein-based pharmaceuticals. This first systematic study clarifies the conditions under which scientists can be assured that their instruments are faithfully measuring the formation of protein aggregates, a major concern because of its impact on quality control and safety in biologic drug manufacturing.


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