Researchers find a new role for a 'Foxy Old Gene'

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Liver cells from mice that do not express FOXA2 (Mutant mice accumulated bile salts and failed to detoxify them properly which resulted in liver damage.). The liver cells in this image show an accumulation of proteins that are used by cells to degrad ...
Liver cells from mice that do not express FOXA2 (Mutant mice accumulated bile salts and failed to detoxify them properly, which resulted in liver damage.). The liver cells in this image show an accumulation of proteins that are used by cells to degrade unwanted substances. Image: Klaus Kaestner, Ph.D., University of Pennsylvania School of Medicine; Nature Medicine
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Researchers at the University of Pennsylvania School of Medicine have discovered that a protein called FOXA2 controls genes that maintain the proper level of bile in the liver. FOXA2 may become the focus for new therapies to treat diseases that involve the regulation of bile salts. The study was published online this week in Nature Medicine.


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