Lipid Nanoparticles Enhance Antitumor Vaccine Activity

Positively charged lipid-based nanoparticles are known to trigger strong immune responses when injected into the body, which can be problematic when attempting to use this type of nanoparticle as a drug delivery vehicle. Now, researchers at Colorado State University, led by Steven Dow, Ph.D., D.V.M., have taken advantage of this effect to boost the activity of a DNA-based anticancer vaccine. This work appears in the journal Cancer Gene Therapy.