For low-cost DNA nanostructures, recycle sticky ends
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The hierarchical approach to building nanostructures from DNA, beginning with nine oligonucleotides and resulting in an 8 x 8 grid. Credit: Constantin Pistol, et al.
Scientists from Duke University have recently demonstrated a new method for assembling large, low-cost DNA nanostructures, in part by reusing the “sticky-ends,” the broken DNA strands used to connect the nanostructures. In their hierarchical self-assembly method, the scientists have demonstrated one of the largest programmable synthetic nanostructures ever synthesized.
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