Scientists identify new regulatory mechanism for critical protein signaling domain

In a study with far-reaching implications, scientists at the Scripps Research Institute and other institutions have for the first time identified a new in vivo regulatory mechanism for the PH Domain, a component of many proteins that allows them to move from a cell's interior to the cell membrane in response to stimulation of cell surface receptors. The findings offer a promising avenue for the development of novel therapies for immunodeficiency or autoimmune diseases.