http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- Cancer cells, like bacteria, can develop resistance to drug therapy, leading to relapse of disease. One approach showing promise in overcoming multidrug resistance in tumors is to combine two different anticancer agents in one nanoscale construct, providing a one-two punch that can prove lethal to such resistant cells. An example of this approach appears in the journal Small. http://www.physorg.com/news176541150.html Nanotechnology Wed, 04 Nov 2009 07:12:55 EST news176541150 Pateamine A (PatA), a natural product first isolated from marine sponges, has attracted considerable attention as a potential anti-cancer agent, and now a new activity has been found for it, which may reveal yet another anti-cancer mechanism. That's the assessment of Daniel Romo, a Texas A&M chemistry professor, and his colleagues at Johns Hopkins University who are pioneers in research involving this novel marine natural product. http://www.physorg.com/news176388679.html Chemistry Mon, 02 Nov 2009 12:51:56 EST news176388679 Two University of Rhode Island associate professors, biophysicists Yana Reshetnyak and Oleg Andreev, have discovered a technology that can detect cancerous tumors and deliver treatment to them without the harming the healthy cells surrounding them, thereby significantly reducing side effects. The URI couple has attracted more than $6 million in grants in four years. In addition, a number of health care and pharmaceutical companies have expressed interest in their work. http://www.physorg.com/news175868491.html Medicine & Health Tue, 27 Oct 2009 13:50:05 EST news175868491 A series of studies have demonstrated that Chrysanthemum indicum possesses antimicrobial, antiinflammatory, immunomodulatory, and neuroprotective effects. Recently, much attention has been devoted to the anticancer activity of Chrysanthemum indicum, especially in hepatocellular carcinoma (HCC). However, its anticancer mechanism of action is still not clear and needs further investigation. http://www.physorg.com/news174915592.html Medicine & Health Fri, 16 Oct 2009 17:10:01 EST news174915592 In new research published in the open-access, peer-reviewed scientific journal PLoS ONE, Dr Patrice Dubreuil and colleagues characterise the pharmacological profile of masitinib (AB1010), a novel tyrosine kinase inhibitor (TKI) that targets the stem cell factor (KIT), PDGFR and Lyn. http://www.physorg.com/news173515782.html Medicine & Health Wed, 30 Sep 2009 08:10:02 EST news173515782 (PhysOrg.com) -- Small pieces of nucleic acid known as short interfering RNAs, or siRNAs, can turn off the production of specific proteins, a property that makes them one of the more promising new classes of anticancer drugs in development. Indeed, at least two siRNA-based anticancer therapies, both delivered to tumors in nanoparticles, have begun human clinical trials. http://www.physorg.com/news172951531.html Nanotechnology Wed, 23 Sep 2009 19:06:33 EST news172951531 Until now, the mode of action of nitrogen-containing bisphosphonate (N-BP) cancer drugs, used to relieve bone pain and to prevent skeletal complications in bone metastasis, has been almost entirely unknown. Researchers writing in BioMed Central's open access journal Genome Biology have used 'barcoded' yeast mutants to identify new biological processes involved in the cellular response to N-BPs, opening up opportunities for the development of new anticancer drugs. http://www.physorg.com/news171743837.html Biology Wed, 09 Sep 2009 19:38:01 EST news171743837 A common weed called American mayapple may soon offer an alternative to an Asian cousin that's been harvested almost to extinction because of its anti-cancer properties. The near-extinct Asian plant, Podophyllyum emodi, produces podophyllotoxin, a compound used in manufacturing etoposide, the active ingredient in a drug used for treating lung and testicular cancer. Podophyllyum emodi is a cousin of the common mayapple weed found in the United States. http://www.physorg.com/news171283180.html Chemistry Fri, 04 Sep 2009 11:50:02 EST news171283180 A process that limits the number of times a cell divides works much differently than had been thought, opening the door to potential new anticancer therapies, researchers at UT Southwestern Medical Center report in the Aug. 7 issue of the journal Cell. http://www.physorg.com/news171026279.html Medicine & Health Tue, 01 Sep 2009 12:18:25 EST news171026279 When bees sting, they pump into their victims a peptide toxin called melittin that destroys cell membranes. Now, by encapsulating this extremely potent molecule within a nanoparticle, researchers at the Washington University School of Medicine in St. Louis have created a potential new type of anticancer therapy with the potential to target a wide range of tumors. This work was reported in the Journal of Clinical Investigation. http://www.physorg.com/news170690607.html Nanotechnology Fri, 28 Aug 2009 16:10:02 EST news170690607 Since the advent of the Human Genome Project an explosion of data has sent the science world scrambling. There is a growing demand to fine-tune genomic codes, which list the "ingredients for life," but do not adequately explain how those ingredients function. http://www.physorg.com/news170502444.html Chemistry Wed, 26 Aug 2009 11:10:06 EST news170502444 Manipulating the functions of melanosomes--the organelles in pigment-producing cells--may enhance the activity of anticancer drugs used against melanoma, according to a new study published online August 24 in the Journal of the National Cancer Institute. http://www.physorg.com/news170351264.html Medicine & Health Tue, 25 Aug 2009 02:50:01 EST news170351264 (PhysOrg.com) -- When bees sting, they pump poison into their victims. Now the toxin in bee venom has been harnessed to kill tumor cells by researchers at Washington University School of Medicine in St. Louis. The researchers attached the major component of bee venom to nano-sized spheres that they call nanobees. http://www.physorg.com/news169150957.html Nanotechnology Mon, 10 Aug 2009 19:23:02 EST news169150957 Like the sensitive seismographs that can pick up tremors of impending earthquakes long before they strike, a similar invention from Tel Aviv University researchers may change the face of molecular biology. http://www.physorg.com/news168523850.html Chemistry Mon, 03 Aug 2009 13:20:04 EST news168523850 The active form of vitamin D3 seems to have anticancer effects. To try and understand the mechanisms underlying these effects, researchers previously set out to identify genes whose expression in a human colon cancer cell line was altered by the active form of vitamin D3. http://www.physorg.com/news166120072.html Medicine & Health Mon, 06 Jul 2009 17:28:10 EST news166120072 A molecule called telomerase, best known for enabling unlimited cell division of stem cells and cancer cells, has a surprising additional role in the expression of genes in an important stem cell regulatory pathway, say researchers at the Stanford University School of Medicine. The unexpected finding may lead to new anticancer therapies and a greater understanding of how adult and embryonic stem cells divide and specialize. http://www.physorg.com/news165674795.html Medicine & Health Wed, 01 Jul 2009 14:40:03 EST news165674795 A research article to be published on June 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Yan Li from Shengjing Hospital of China Medical University studied the growth inhibitory effects of Alisol B acetat and determined its mechanism of antitumor activity in human gastric cancer cell line SGC7901. http://www.physorg.com/news165488748.html Medicine & Health Mon, 29 Jun 2009 10:40:01 EST news165488748 (PhysOrg.com) -- Researchers from the University of Missouri-Columbia report in the Journal of Materials Chemistry that chemicals in tea are the best yet discovered to make consistent, biologically safe gold nanoparticles. More importantly, these gold nanoparticles show promising anticancer properties. http://www.physorg.com/news160065861.html Nanotechnology Mon, 27 Apr 2009 15:45:11 EST news160065861 (PhysOrg.com) -- Ten years ago, William Fenical of the Scripps Institution of Oceanography isolated from an ocean-living fungus a compound that has since shown the ability to kill cancer cells in the lab. Now, for the first time, MIT chemists have synthesized the compound, an advance that could open the door to new drug treatments for cancer. http://www.physorg.com/news159974241.html Chemistry Sun, 26 Apr 2009 14:18:00 EST news159974241 A new therapy for metastatic prostate cancer has shown considerable promise in early clinical trials involving patients whose disease has become resistant to current drugs. http://www.physorg.com/news158344627.html Medicine & Health Tue, 07 Apr 2009 17:37:37 EST news158344627 Researchers might one day brew up a cancer treatment in their afternoon cuppa, says a study in a Royal Society of Chemistry journal. http://www.physorg.com/news157097297.html Nanotechnology Tue, 24 Mar 2009 07:09:10 EST news157097297 Breast cancer patients face many horrors, including those that arise when fighting the cancer itself. Medications given during chemotherapy can have wicked side effects, including vomiting, dizziness, anemia and hair loss. These side effects occur because medications released into the body target healthy cells as well as tumor cells. http://www.physorg.com/news155940166.html Nanotechnology Tue, 10 Mar 2009 21:43:00 EST news155940166 Chemotherapy is an integral part of modern cancer treatment, but it's not always effective. Successful chemotherapy depends on the ability of anticancer drugs to escape from the bloodstream through the leaky blood vessels that often surround tumors. http://www.physorg.com/news152773446.html Medicine & Health Mon, 02 Feb 2009 05:04:42 EST news152773446 Researchers in Pennsylvania are reporting for the first time that nanoparticles 1/5,000 the diameter of a human hair encapsulating an experimental anticancer agent, kill human melanoma and drug-resistant breast cancer cells growing in laboratory cultures. The discovery could lead to the development of a new generation of anti-cancer drugs that are safer and more effective than conventional chemotherapy agents, the scientists suggest. The research is scheduled for the Dec. 10 issue of ACS' Nano Letters. http://www.physorg.com/news148573402.html Nanotechnology Mon, 15 Dec 2008 14:23:22 EST news148573402 Biologists at the University of Rochester have found that small-bodied rodents with long lifespans have evolved a previously unknown anti-cancer mechanism that appears to be different from any anticancer mechanisms employed by humans or other large mammals. The findings are published in today's issue of Aging Cell. http://www.physorg.com/news140929220.html Biology Thu, 18 Sep 2008 04:00:20 EST news140929220 Could a substance from the jasmine flower hold the key to an effective new therapy to treat cancer? Prof. Eliezer Flescher of The Sackler Faculty of Medicine, Tel Aviv University thinks so. He and his colleagues have developed an anti-cancer drug based on a decade of research into the commercial applications of the compound Jasmonate, a synthetic compound derived from the flower itself. Prof. Flescher began to research the compound about a decade ago, and with his recent development of the drug, his studies have now begun to bear meaningful fruit. http://www.physorg.com/news138883274.html Medicine & Health Mon, 25 Aug 2008 11:41:14 EST news138883274