http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Removing the PKCI/HINT1 gene from mice has an anti-depressant-like and anxiolytic-like effect. Researchers writing in the open access journal BMC Neuroscience applied a battery of behavioral tests to the PKCI/HINT1 knockout animals, concluding that the deleted gene may have an important role in mood regulation. http://www.physorg.com/news177276531.html Medicine & Health Thu, 12 Nov 2009 19:30:03 EST news177276531 Malfunctioning circadian clock genes may be responsible for bipolar disorder in children. Researchers writing in the open access journal BMC Psychiatry found four versions of the regulatory gene RORB that were associated with pediatric bipolar disorder. http://www.physorg.com/news177224772.html Medicine & Health Thu, 12 Nov 2009 05:16:31 EST news177224772 (PhysOrg.com) -- Sufferers of schizophrenia and bipolar disorder are being brought together in a major new study to determine the diseases? common genetic causes. http://www.physorg.com/news174906706.html Medicine & Health Fri, 16 Oct 2009 10:13:40 EST news174906706 (PhysOrg.com) -- With the school year kicking into full gear, mood disorders such as bipolar disorder and depression can start to manifest themselves -- and parents need to be on the lookout for them in their children. http://www.physorg.com/news174238668.html Medicine & Health Thu, 08 Oct 2009 16:50:02 EST news174238668 Bipolar disorder, or manic-depression, causes severe and unusual shifts in mood and energy, affecting a person's ability to perform everyday tasks. With symptoms often starting in early adulthood, bipolar disorder has been thought of traditionally as a lifelong disorder. Now, University of Missouri researchers have found evidence that nearly half of those diagnosed between the ages of 18 and 25 may outgrow the disorder by the time they reach 30. http://www.physorg.com/news173452271.html Medicine & Health Tue, 29 Sep 2009 14:30:01 EST news173452271 75% of the cases of paediatric bipolar disorder are diagnosed late - up to 18 months - due to the symptoms manifesting themselves in a different manner depending on whether the patient is a child or adult. Moreover, 25% of sufferers have a delay in their medical diagnoses of up to three years and four months, according to a study by the Department of Psychiatry and Medical Psychology at the University Hospital of Navarra, in collaboration with the Paediatric Psychopharmacology Unit at the l Massachusetts General Hospital at Harvard University (Boston, United States). http://www.physorg.com/news172822213.html Medicine & Health Tue, 22 Sep 2009 07:11:16 EST news172822213 Chances are, we all know someone like Marya Hornbacher. We just don't realize that we do because, like Hornbacher, these someones are charming, smart, well-spoken and prosperous -- not at all like people who are (cough) bipolar. http://www.physorg.com/news169151492.html Medicine & Health Mon, 10 Aug 2009 23:40:01 EST news169151492 A year ago, a study by Rhode Island Hospital and Brown University researchers reported that fewer than half the patients previously diagnosed with bipolar disorder received an actual diagnosis of bipolar disorder after using a comprehensive, psychiatric diagnostic interview tool --the Structured Clinical Interview for DSM-IV (SCID). In this follow-up study, the researchers have determined the actual diagnoses of those patients. Their study is published in the July 28 ahead of print online edition of The Journal of Clinical Psychiatry. http://www.physorg.com/news168084800.html Medicine & Health Wed, 29 Jul 2009 11:13:52 EST news168084800 A multi-national group of investigators, including a scientist at the University of North Carolina at Chapel Hill, has discovered that nearly a third of the genetic basis of schizophrenia may be attributed to the cumulative actions of thousands of common genetic variants. The effects of each of these genetic changes, innocuous on its own, add up to a significant risk for developing both schizophrenia and bipolar disorder. http://www.physorg.com/news165674543.html Medicine & Health Wed, 01 Jul 2009 13:42:44 EST news165674543 A new study from Bradley Hospital and The Warren Alpert Medical School of Brown University, as well as two other institutions, adds to mounting evidence that clinicians consider irritability as a symptom when diagnosing pediatric bipolar disorder. http://www.physorg.com/news165073111.html Medicine & Health Wed, 24 Jun 2009 14:39:30 EST news165073111 (AP) -- Three blockbuster psychiatric drugs currently approved for adults also appear to work in adolescents, though federal health officials have concerns about exposing younger patients to the drugs' side effects. http://www.physorg.com/news163421652.html Medicine & Health Fri, 05 Jun 2009 11:54:35 EST news163421652 Mayo Clinic researchers have found that bipolar disorder is more costly than other chronic conditions such as diabetes, depression, asthma or coronary artery disease. These findings are based on a review of health care claim costs. Specialty care costs (the costs of seeing any specialist and all tests ordered) were especially higher for bipolar patients. Results of this review are being presented today at the Annual Meeting of the American Psychiatric Association in San Francisco. http://www.physorg.com/news162133626.html Medicine & Health Thu, 21 May 2009 14:07:34 EST news162133626 (AP) -- Ivory Jackson had Alzheimer's, but that wasn't what killed him. At 77, he was smashed in the face with a clock radio as he lay in his nursing home bed. http://www.physorg.com/news156957294.html Medicine & Health Sun, 22 Mar 2009 16:15:36 EST news156957294 A gene that is arguably the most studied "schizophrenia gene" plays an unanticipated role in the brain: It controls the birth of new neurons in addition to their integration into existing brain circuitry, according to a report in the March 20th issue of the journal Cell, a Cell Press publication. The finding suggests that loss of the gene, as occurs in some cases of schizophrenia as well as bipolar disorder and major depression, may "tip the balance" in the brain, leading to an increased risk of compromised cognition and behavioral abnormalities, the researchers said. http://www.physorg.com/news156687739.html Medicine & Health Thu, 19 Mar 2009 13:25:08 EST news156687739 Children and teens of parents with bipolar disorder appear to have an increased risk of early-onset bipolar disorder, mood disorders and anxiety disorders, according to a report in the March issue of Archives of General Psychiatry. http://www.physorg.com/news155240464.html Medicine & Health Mon, 02 Mar 2009 18:21:28 EST news155240464 In a study published in The American Journal of Psychiatry, a team of researchers led by Mayo Clinic psychiatrist Mark Frye, M.D., attempted to identify what factors make some people with bipolar depression more likely to experience treatment-emergent mania (TEM). http://www.physorg.com/news153594845.html Medicine & Health Wed, 11 Feb 2009 17:14:41 EST news153594845 Bipolar disorder appears to increase the risk of early death from medical illnesses, according to a literature review study published as the lead article this week in the journal Psychiatric Services. http://www.physorg.com/news152791762.html Medicine & Health Mon, 02 Feb 2009 10:14:44 EST news152791762 Neuroscientists at the Indiana University School of Medicine have created the first comprehensive map of genes likely to be involved in bipolar disorder, according to research published online Nov. 21 in the American Journal of Medical Genetics. http://www.physorg.com/news146511601.html Medicine & Health Fri, 21 Nov 2008 17:40:01 EST news146511601 Family-focused therapy, when combined with medication, appears effective in stabilizing symptoms of depression among teens with bipolar disorder, according to a report in the September issue of Archives of General Psychiatry. http://www.physorg.com/news139508528.html Medicine & Health Mon, 01 Sep 2008 17:22:08 EST news139508528 Older age among fathers may be associated with an increased risk for bipolar disorder in their offspring, according to a report in the September issue of Archives of General Psychiatry. http://www.physorg.com/news139508351.html Medicine & Health Mon, 01 Sep 2008 17:19:11 EST news139508351 A large genetic study of bipolar disorder has implicated machinery that balances levels of sodium and calcium in neurons. The disorder was associated with variation in two genes that make components of such ion channels. Although it's not yet known if or how the suspect genetic variation might affect the balance machinery, the results point to the possibility that bipolar disorder might stem, at least in part, from malfunction of ion channels. http://www.physorg.com/news138198902.html Medicine & Health Sun, 17 Aug 2008 13:35:02 EST news138198902 Both schizophrenia and bipolar disorder can be disabling conditions, and both present clinically with significant mood and psychotic symptoms. These two illnesses also share genetic variants that might be involved in the predisposition to both disorders. A new study scheduled for publication in the July 15th issue of Biological Psychiatry sought to analyze the patterns of gene expression in the brains of individuals diagnosed with one of these disorders to search for a common "characteristic [genetic] signature." http://www.physorg.com/news135509409.html Medicine & Health Thu, 17 Jul 2008 10:30:09 EST news135509409