http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health has stopped a clinical trial testing a drug treatment for pulmonary hypertension in adults with sickle cell disease nearly one year early due to safety concerns. In an interim review of safety data from 33 participants who completed 16 weeks of treatment, researchers found that, compared to participants on placebo (dummy pill), participants taking sildenafil (Revatio) were significantly more likely to have serious medical problems. The most common problem was episodes of severe pain called sickle cell crises, which resulted in hospitalization. No deaths have been associated with the drug in the clinical trial. http://www.physorg.com/news168017149.html Medicine & Health Tue, 28 Jul 2009 16:26:19 EST news168017149 Scientists at Penn State have shed light on some of the processes that regulate genes -- such as the processes that ensure that proteins are produced at the correct time, place, and amount in an organism -- and they also have shed light on the evolution of the DNA regions that regulate genes. The team focused on regulatory regions that, when bound to the protein GATA1, are thought to turn on genes that play an important role in the development of red blood cells. "Our findings could help others to develop drugs to treat people who suffer from sickle-cell anemia and other blood disorders," said Ross Hardison, the T. Ming Chu Professor of Biochemistry and Molecular Biology and the team's leader. The results will be published on 1 December 2008 in the journal Genome Research. http://www.physorg.com/news146833211.html Biology Tue, 25 Nov 2008 11:00:11 EST news146833211 (PhysOrg.com) -- Scientists at Penn State have shed light on some of the processes that regulate genes -- such as the processes that ensure that proteins are produced at the correct time, place, and amount in an organism -- and they also have shed light on the evolution of the DNA regions that regulate genes. The team focused on regulatory regions that, when bound to the protein GATA1, are thought to turn on genes that play an important role in the development of red blood cells. http://www.physorg.com/news146244851.html Biology Tue, 18 Nov 2008 15:34:11 EST news146244851