http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- A research team led by Nancy Speck, PhD, Professor of Cell and Developmental Biology at the University of Pennsylvania School of Medicine, has identified the location and developmental timeline in which a majority of bone marrow stem cells form in the mouse embryo. The findings, appearing online this week in the journal Nature, highlight critical steps in the origin of hematopoietic (or blood) stem cells (HSCs), says senior author Speck, who is also an Investigator with the Abramson Family Cancer Research Institute at Penn. http://www.physorg.com/news150731605.html Biology Fri, 09 Jan 2009 13:53:25 EST news150731605 A new study sheds light on a little understood biological process called quiescence, which enables blood-forming stem cells to exist in a dormant or inactive state in which they are not growing or dividing. According to the study's findings, researchers identified the genetic pathway used to maintain a cell's quiescence, a state that allows bone marrow cells to escape the lethal effects of standard cancer treatments. http://www.physorg.com/news150726406.html Biology Fri, 09 Jan 2009 12:26:46 EST news150726406 Scientists have tricked bone marrow into releasing extra adult stem cells into the bloodstream, a technique that they hope could one day be used to repair heart damage or mend a broken bone, in a new study published today in the journal Cell Stem Cell. http://www.physorg.com/news150645110.html Biology Thu, 08 Jan 2009 13:51:50 EST news150645110 The novel design of a deep muscle along the spinal column called the multifidus muscle may in fact be key to spinal support and a healthy back, according to researchers at the University of California, San Diego School of Medicine. Their findings about the potentially important "scaffolding" role of this poorly understood muscle has been published on line in advance of the January issue of the Journal of Bone and Joint Surgery. http://www.physorg.com/news150557758.html Medicine & Health Wed, 07 Jan 2009 13:35:58 EST news150557758 (PhysOrg.com) -- Artificial bone marrow that can continuously make red and white blood cells has been created in a University of Michigan lab. http://www.physorg.com/news149189072.html Biology Mon, 22 Dec 2008 17:24:32 EST news149189072 A new report demonstrates how a sensitive imaging technique gives scientists the upper hand in seeking out bacteria in chronic infections. http://www.physorg.com/news149170837.html Medicine & Health Mon, 22 Dec 2008 12:20:37 EST news149170837 Learning how leukemia takes over privileged "niches" within the bone marrow is helping researchers develop treatment strategies that could protect healthy blood-forming stem cells and improve the outcomes of bone marrow transplantation for leukemia and other types of cancer. http://www.physorg.com/news148832246.html Medicine & Health Thu, 18 Dec 2008 14:17:26 EST news148832246 (PhysOrg.com) -- Biologists face the major challenge of understanding genetic and environmental risk factors underlying human diseases. Surprisingly, animal species in the wild have sometimes acquired the characteristics of a human disease through evolution. http://www.physorg.com/news148753307.html Biology Wed, 17 Dec 2008 16:21:47 EST news148753307 An interim analysis of a breast cancer prevention study using exemestane (Aromasin(R)) finds an "acceptable" level of bone loss. http://www.physorg.com/news148488121.html Medicine & Health Sun, 14 Dec 2008 14:42:01 EST news148488121 Like it or not, your living room probably says a lot about you. Given a few uninterrupted moments to poke around, a stranger could probably get a pretty good idea of your likes and dislikes, and maybe even your future plans. Scientists at the Stanford University School of Medicine employing a similar "peeping Tom" tactic to learn more about how stem cells develop have taken a significant step forward by devising a way to recreate the cells' lair - a microenvironment called a niche - in an adult animal. http://www.physorg.com/news148138314.html Biology Wed, 10 Dec 2008 13:31:54 EST news148138314 Oregon Health & Science University Knight Cancer Institute researchers have found that an experimental drug successfully blocks an enzyme that causes some bone marrow cancers. http://www.physorg.com/news148049243.html Medicine & Health Tue, 09 Dec 2008 12:47:23 EST news148049243 Patients respond well to a new three-drug combination for indolent B cell lymphoma that also spares them prolonged, potentially lethal, suppression of blood production in the bone marrow, researchers at The University of Texas M. D. Anderson Cancer Center report today at the 50th annual meeting of the American Society of Hematology. http://www.physorg.com/news148048772.html Medicine & Health Tue, 09 Dec 2008 12:39:32 EST news148048772 A new study by researchers at The Medical College of Wisconsin Cancer Center Milwaukee, has found that African Americans and whites have identical survival rates after undergoing autologous (self donor) bone marrow transplant treatment for a common cancer of the bone marrow (multiple myeloma). However, in a previous study the researchers showed that African Americans were only half as likely as whites to actually receive a bone marrow transplant, the well-established life-prolonging treatment for the disease. http://www.physorg.com/news147968414.html Medicine & Health Mon, 08 Dec 2008 14:20:14 EST news147968414 (PhysOrg.com) -- Investigators from Massachusetts General Hospital (MGH) have found a subpopulation of hematopoietic stem cells, the source of all blood and immune system cells, that reproduce much more slowly than previously anticipated. Use of these cells may improve the outcome of stem cell transplants - also called bone marrow transplants - for the treatment of leukemia and other marrow-based diseases. The report will appear in the journal Nature Biotechnology and is being released online to coincide with a similar study in the journal Cell. http://www.physorg.com/news147721045.html Biology Fri, 05 Dec 2008 17:37:25 EST news147721045 The apparent success of a case in which German doctors cured a man of AIDS using a bone marrow transplant comes as no surprise to Gerhard Bauer, a UC Davis stem cell researcher. Bauer has been working for more than 10 years on a similar cure for AIDS based on replacing the devastated immune system of an HIV-infected patient with stem cells that have been engineered to resist human immunodeficiency syndrome. http://www.physorg.com/news147720965.html Medicine & Health Fri, 05 Dec 2008 17:36:05 EST news147720965 Stem cells derived from bone marrow may serve as a novel therapeutic option to treat a disease called epidermolysis bullosa (EB), a disorder characterized by extraordinarily fragile skin, according to a study prepublished online in Blood, the official journal of the American Society of Hematology. http://www.physorg.com/news147618795.html Medicine & Health Thu, 04 Dec 2008 13:13:15 EST news147618795 A method of producing synthetic bone, using techniques normally used to make catalytic converters for cars, is being developed by researchers at WMG at the University of Warwick. http://www.physorg.com/news147615891.html Medicine & Health Thu, 04 Dec 2008 12:24:51 EST news147615891 Many specialized cells, such as in the skin, intestinal mucosa or blood, have a lifespan of only a few days. For these tissues to function, a steady replenishment of specialized cells is indispensable. This is the task of so-called "adult" stem cells also known as tissue stem cells. http://www.physorg.com/news147615685.html Medicine & Health Thu, 04 Dec 2008 12:21:25 EST news147615685 Diets that are high in protein and cereal grains produce an excess of acid in the body which may increase calcium excretion and weaken bones, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The study found that increasing the alkali content of the diet, with a pill or through a diet rich in fruits and vegetables has the opposite effect and strengthens skeletal health. http://www.physorg.com/news147533286.html Medicine & Health Wed, 03 Dec 2008 13:28:06 EST news147533286 Men who survived childhood leukemia treatment into adulthood were more likely to have low bone mineral density than other adults their age, putting them at risk of osteoporosis and bone fractures, according to a new study. http://www.physorg.com/news147531034.html Medicine & Health Wed, 03 Dec 2008 12:50:34 EST news147531034 New research reveals that computed tomography (CT) colonography, also known as virtual colonoscopy, has the potential to screen for two diseases at once -colorectal cancer and osteoporosis, both of which commonly affect adults over age 50. Results of the study will be presented today at the annual meeting of the Radiological Society of North America (RSNA). http://www.physorg.com/news147452973.html Medicine & Health Tue, 02 Dec 2008 15:09:33 EST news147452973 (PhysOrg.com) -- Bone growth is controlled in the gut through serotonin, the same naturally present chemical used by the brain to influence mood, appetite and sleep, according to a new discovery from researchers at Columbia University Medical Center. Until now, the skeleton was thought to control bone growth, and serotonin was primarily known as a neurotransmitter acting in the brain. This new insight could transform how osteoporosis is treated in the future by giving doctors a way to increase bone mass, not just slow its loss. Findings are reported in the Nov. 26, 2008 issue of Cell. http://www.physorg.com/news146922394.html Medicine & Health Wed, 26 Nov 2008 11:46:34 EST news146922394 Researchers at the University of Toronto, Faculty of Medicine, Toronto, Canada, have discovered that adiponectin, a protein secreted from adipocytes, is a metabolic link that can explain, in part, the known positive relationship between obesity and both bone mineral density and reduced susceptibility to fractures. This study appears in the December issue of Experimental Biology and Medicine. http://www.physorg.com/news146853539.html Medicine & Health Tue, 25 Nov 2008 16:38:59 EST news146853539 Osteoporosis is a growing concern among breast cancer survivors and their doctors, because certain cancer drugs can cause bone loss. http://www.physorg.com/news146335065.html Medicine & Health Wed, 19 Nov 2008 16:37:45 EST news146335065 Children and teenagers with even mild cases of anorexia exhibit abnormal bone structure, according to a new study appearing in the December issue of Radiology and presented at the annual meeting of the Radiological Society of North America (RSNA). http://www.physorg.com/news146220357.html Medicine & Health Tue, 18 Nov 2008 08:45:57 EST news146220357 Patients treated for locally advanced non-small cell lung cancer who receive chemotherapy and proton beam therapy have fewer instances of bone marrow toxicity than patients who receive the standard treatment of intensity-modulated radiation (IMRT) and concurrent chemotherapy, according to researchers from The University of Texas M. D. Anderson Cancer Center. http://www.physorg.com/news145808497.html Medicine & Health Thu, 13 Nov 2008 14:21:37 EST news145808497 Montreal, November 13, 2008 - A new cross-Canada study has found that breast and prostate cancer treatment can foster bone loss. In the online edition of the Journal of Clinical Oncology, the scientists explain how loss of bone mass might affect 46,000 people diagnosed with breast and prostate cancer each year* and place them at increased risk for osteoporosis and fractures. http://www.physorg.com/news145799650.html Medicine & Health Thu, 13 Nov 2008 11:54:10 EST news145799650 A unique approach to bone marrow transplantation pioneered in part by a Children's Hospital of Pittsburgh of UPMC physician has proven to be the only safe and effective cure for sickle cell disease, according to a new study. http://www.physorg.com/news145274886.html Medicine & Health Fri, 07 Nov 2008 10:08:06 EST news145274886 Pycnodysostosis, a condition from which the painter Henri de Toulouse-Lautrec suffered, is a genetic disease characterized by short stature. This rare disease, surprisingly, provides a window into how joints are destroyed by arthritis. It is caused by deficiency of an enzyme known as cathepsin K which hampers osteoclasts (the cells that break down bone in bone modeling and repair), leading to poor bone resorption and dense, brittle bones. http://www.physorg.com/news145024355.html Medicine & Health Tue, 04 Nov 2008 12:32:35 EST news145024355 Scientists have discovered a crucial step in hormone-triggered bone growth, a finding that could lead to new osteoporosis drugs and better bone-building therapies, according to a new study. http://www.physorg.com/news144732228.html Medicine & Health Sat, 01 Nov 2008 04:23:48 EST news144732228