http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. New research by the University of Adelaide could help explain why some people are more prone to Crohn's disease, ulcerative colitis and other autoimmune diseases. http://www.physorg.com/news180267101.html Medicine & Health Thu, 17 Dec 2009 10:40:02 EST news180267101 In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease. http://www.physorg.com/news177515874.html Medicine & Health Sun, 15 Nov 2009 13:59:14 EST news177515874 (PhysOrg.com) -- An international team including researchers with the National Institutes of Health has discovered that mutations in either of two related genes cause a severe and rare form of inflammatory bowel disease (IBD) in young children. http://www.physorg.com/news176658665.html Medicine & Health Thu, 05 Nov 2009 16:20:03 EST news176658665 Currently, 5-8% of the U.S. population is afflicted with an autoimmune disease. Many of these are chronic and require life-long care. Moreover, different autoimmune diseases aggregate within a single family, suggesting they are caused by disruptions in common biological pathways. http://www.physorg.com/news176047087.html Medicine & Health Thu, 29 Oct 2009 23:00:01 EST news176047087 Findings from a new retrospective cohort study presented at the American College of Gastroenterology's 74th Annual Scientific meeting in San Diego indicate that patients with Inflammatory Bowel Disease (IBD), especially those receiving the thiopurine class of medications to treat IBD, may be at risk for developing non-melanoma skin cancer (NMSC). http://www.physorg.com/news175776162.html Medicine & Health Mon, 26 Oct 2009 12:00:08 EST news175776162 The probiotic, Bacillus polyfermenticus, can help mice recover from colitis, a new study has found. Mice treated with B. polyfermenticus during the non-inflammatory period of the disease had reduced rectal bleeding, their tissues were less inflamed and they gained more weight than mice that did not receive the treatment. http://www.physorg.com/news175748244.html Medicine & Health Mon, 26 Oct 2009 04:20:02 EST news175748244 Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology. http://www.physorg.com/news175324588.html Medicine & Health Wed, 21 Oct 2009 06:17:13 EST news175324588 New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract. http://www.physorg.com/news174239504.html Medicine & Health Thu, 08 Oct 2009 16:52:10 EST news174239504 Here's another reason why you should take your vitamins. A new research report appearing in the October 2009 print issue of the Journal of Leukocyte Biology suggests that retinoic acid, the oxidized form of vitamin A, could be a beneficial treatment for people suffering from ulcerative colitis and other irritable bowel diseases. Specifically they found that retinoic acid helps suppress out-of-control inflammation, which is a hallmark of active ulcerative colitis. http://www.physorg.com/news173610231.html Medicine & Health Thu, 01 Oct 2009 11:30:01 EST news173610231 A new study led by Mayo Clinic researchers has found that ulcerative colitis patients had a 41 percent reduction in colectomy after a year when treated with infliximab, according to a study published in the October 2009 issue of Gastroenterology. http://www.physorg.com/news173595232.html Medicine & Health Thu, 01 Oct 2009 06:20:01 EST news173595232 In new research published in the open-access, peer-reviewed scientific journal PLoS ONE, Dr Patrice Dubreuil and colleagues characterise the pharmacological profile of masitinib (AB1010), a novel tyrosine kinase inhibitor (TKI) that targets the stem cell factor (KIT), PDGFR and Lyn. http://www.physorg.com/news173515782.html Medicine & Health Wed, 30 Sep 2009 08:10:02 EST news173515782 University of Michigan scientists say they have uncovered a fundamentally new mechanism that holds in check aggressive immune cells that can attack the body's own cells. The findings open a new avenue of research for future therapies for conditions ranging from autoimmune diseases to organ transplants to cancer. http://www.physorg.com/news171028780.html Chemistry Tue, 01 Sep 2009 13:10:02 EST news171028780 Anti-microbial antibody formation has been reported in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet. The importance of newly discovered inflammatory bowel disease-associated antibodies (including anti-glycan antibodies and anti-OMP) in celiac disease is not sure. The presence of anti-microbial antibodies in relation to clinical presentation of the disease and NOD2/CARD15 mutations was also not investigated. http://www.physorg.com/news170504362.html Medicine & Health Wed, 26 Aug 2009 11:50:01 EST news170504362 For the first time, scientists have used a genetically engineered "friendly" bacterium to deliver a therapy. http://www.physorg.com/news170015980.html Medicine & Health Thu, 20 Aug 2009 21:40:01 EST news170015980 Primary sclerosing cholangitis (PSC) is an uncommon chronic liver disease characterized by progressive inflammation and destruction of the bile ducts. The disease progresses slowly, usually leading to biliary cirrhosis, portal hypertension and liver failure over a 10-15 year period. PSC is a common cause of adult cholestatic liver diseases and a primary source behind many of the liver transplantations in U.S. adults. At least 70% of PSC cases are associated with chronic inflammatory bowel disease (IBD), usually ulcerative colitis. Currently, there is no cure for PSC and prospective treatments remain ineffective. http://www.physorg.com/news169898396.html Medicine & Health Wed, 19 Aug 2009 11:20:04 EST news169898396 (PhysOrg.com) -- The use of animals in scientific research continues to be one of the most controversial issues in scientific research. Now Viewpoints, a new series of papers published in the European Journal of Immunology, brings experts from across the globe to decide if the ends justify the means. http://www.physorg.com/news169309629.html Medicine & Health Wed, 12 Aug 2009 15:50:02 EST news169309629 A research team from Hungary investigated the probability of disease behavior changes in a well-characterized Crohn's disease cohort with strict clinical follow-up. They found that perianal disease, small bowel disease, smoking, prior steroid use, early AZA or AZA/biological therapy are all predictors of disease behavior change in CD patients. http://www.physorg.com/news169120957.html Medicine & Health Mon, 10 Aug 2009 15:10:02 EST news169120957 (PhysOrg.com) -- Turmeric - the key ingredient in curry - has been used in India for thousands of years to help treat colds, inflammation, arthritis and even cancer. http://www.physorg.com/news167932895.html Medicine & Health Mon, 27 Jul 2009 17:20:01 EST news167932895 Researchers at The University of Texas Health Science Center at Houston say one organism discovered during their study may unlock the key to what causes colic, inconsolable crying in an otherwise healthy baby. http://www.physorg.com/news167662231.html Medicine & Health Fri, 24 Jul 2009 14:10:07 EST news167662231 Although visceral hypersensitivity is considered a hallmark feature of IBS, conflicting evidence exists regarding somatic hypersensitivity in this patient population. Several investigators have found no evidence for heightened somatic pain sensitivity in IBS patients. Also, others have reported similar cold presser pain tolerance in IBS patients and controls. http://www.physorg.com/news167476283.html Medicine & Health Wed, 22 Jul 2009 10:11:44 EST news167476283 Researchers from Case Western Reserve University School of Medicine identified a novel link between ITCH, a gene known to regulate inflammation in the body and NOD2, a gene which causes the majority of genetic Crohn's Disease diagnoses. ITCH, when malfunctioning, causes widespread inflammatory diseases, including inflammatory bowel disease, gastritis, uncontrolled skin inflammation, and pulmonary pneumonitis. http://www.physorg.com/news166360829.html Medicine & Health Thu, 09 Jul 2009 12:30:02 EST news166360829 Researchers at the University of California, San Diego School of Medicine have developed the first mouse model for auto-inflammatory diseases, disorders that involve the over-activation of the body's innate, primitive immune system. Their study, published early on-line in Cell Immunity on June 4, suggests that the innate - not adaptive - immune system drives auto-inflammatory diseases. The findings could open new therapeutic directions for research into disorders such as gout or inflammatory bowel disease. http://www.physorg.com/news163343219.html Medicine & Health Thu, 04 Jun 2009 14:07:50 EST news163343219 An electronic diagnostic tool called the SmartPill is swallowed by patients in order to take measurements as it travels through the gastrointestinal tract. A new study by physician-scientists at NewYork-Presbyterian/Weill Cornell Medical Center used the device in patients with mild to moderate ulcerative colitis (UC), determining that they have significantly more acidic pH in their colons, compared with the average person -- a finding that may impact treatment strategy. http://www.physorg.com/news163259753.html Medicine & Health Wed, 03 Jun 2009 14:56:21 EST news163259753 Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD). The team, co-led by Judith Bond, Ph.D., Distinguished Professor and Chair of Biochemistry and Molecular Biology at Penn State College of Medicine, and Daniel Lottaz, Department of Rheumatology and Clinical Immunology at the University of Bern, Switzerland, could potentially lead to therapies to help the half-a-million Americans affected by ulcerative colitis and Crohn's disease, collectively referred to as IBD. http://www.physorg.com/news163159904.html Medicine & Health Tue, 02 Jun 2009 11:12:24 EST news163159904 (PhysOrg.com) -- UCLA scientists have linked for the first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the early identification and treatment of human inflammatory disorders, some of which increase risk for several types of cancer. http://www.physorg.com/news163044358.html Medicine & Health Mon, 01 Jun 2009 03:06:22 EST news163044358 One of Laurie Keefer's patients was afraid to be a bridesmaid in a friend's wedding, others worried about traveling with the boss or even going to parties in peoples' homes. http://www.physorg.com/news161440291.html Medicine & Health Wed, 13 May 2009 13:32:16 EST news161440291 Scientists at The University of Nottingham are investigating whether stem cell markers could have a role to play in speeding up wound healing in patients suffering from inflammatory bowel disease (IBD). http://www.physorg.com/news160154197.html Medicine & Health Tue, 28 Apr 2009 16:16:58 EST news160154197 MR enterography is an effective tool to evaluate and guide treatment of patients with Crohn's Disease (a common form of inflammatory bowel disease that typically affects young people) without exposing them to radiation, according to a study performed at the Warren Alpert School of Medicine/Brown University in Providence, RI. http://www.physorg.com/news159721554.html Medicine & Health Thu, 23 Apr 2009 16:06:44 EST news159721554 Scientists at the University of Liverpool have found that understanding the precise timing of communication between cells that coordinate the body's response to disease could be key to new drug developments. http://www.physorg.com/news158506507.html Medicine & Health Thu, 09 Apr 2009 14:37:51 EST news158506507 A team of scientists at The Scripps Research Institute has linked a mouse mutation to an increased susceptibility for developing inflammatory bowel disease -- represented in humans as Crohn's disease and ulcerative colitis, which together are estimated to affect more than a million people in the United States. The findings may one day lead to new and better treatments for the disease. http://www.physorg.com/news153504093.html Medicine & Health Tue, 10 Feb 2009 16:02:15 EST news153504093