http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Duke University Medical Center researchers have figured out how stem cells in the malignant brain cancer glioma may be better able to resist radiation therapy. And using a drug to block a particular signaling pathway in these cancer stem cells, they were able to kill many more glioma cells with radiation in a laboratory experiment. http://www.physorg.com/news178983338.html Medicine & Health Wed, 02 Dec 2009 13:41:28 EST news178983338 Ohio State University cancer researchers have developed a tumor-attacking virus that both kills brain-tumor cells and blocks the growth of new tumor blood vessels. http://www.physorg.com/news178888627.html Medicine & Health Tue, 01 Dec 2009 11:19:03 EST news178888627 Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene. This breakthrough discovery shows that the mutated form of IDH1 produces a metabolite, 2-hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas, the most common type of brain cancers. This discovery appears to reverse the previously held belief that IDH1 was non functional for cancer-causing activity. It is also one of the first reported instances where a metabolic enzyme such as IDH1 is shown to play a role in cancer formation, in this case through altered metabolic activity. http://www.physorg.com/news178121436.html Medicine & Health Sun, 22 Nov 2009 14:11:45 EST news178121436 St. Jude Children's Research Hospital and the University of Florida Proton Therapy Institute have formed a collaboration to provide proton therapy for St. Jude patients. The announcement follows the approval of the first clinical study to evaluate the use of proton therapy for rare brain cancers in children younger than 3 years old. http://www.physorg.com/news176997034.html Medicine & Health Mon, 09 Nov 2009 13:52:05 EST news176997034 SAO PAULO, BRAZIL ― A team of researchers led by The University of Texas M. D. Anderson Cancer Center unveiled results today from the largest-ever collaborative study addressing the treatment of a rare pediatric brain tumor. The findings suggest a new standard protocol could improve survival nearly two-fold for pediatric patients with choroid plexus tumors, as reported at the 41st Annual Meeting of the International Society of Pediatric Oncology (SIOP). http://www.physorg.com/news174302559.html Medicine & Health Fri, 09 Oct 2009 11:00:01 EST news174302559 While little is known about the causes of glioma, researchers at the National Cancer Institute have found that this rare but often deadly form of brain cancer may be linked to early life physical activity and height. http://www.physorg.com/news174057842.html Medicine & Health Tue, 06 Oct 2009 14:27:10 EST news174057842 (PhysOrg.com) -- Scientists from the U.S. Department of Energy`s (DOE) Argonne National Laboratory and the University of Chicago Medical Center`s Brain Tumor Center have developed a way to target brain cancer cells using inorganic titanium dioxide nanoparticles bonded to antibodies. Thousands of people die from malignant brain tumors every year, and the tumors are often resistant to conventional therapies. These composite nanoparticles eventually may provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. http://www.physorg.com/news172951692.html Nanotechnology Thu, 24 Sep 2009 07:10:01 EST news172951692 In an advance toward better treatments for the most serious form of brain cancer, scientists in Illinois are reporting development of the first nanoparticles that seek out and destroy brain cancer cells without damaging nearby healthy cells. The study is scheduled for the Sept. 9 issue of ACS' Nano Letters. http://www.physorg.com/news171745889.html Nanotechnology Wed, 09 Sep 2009 20:12:29 EST news171745889 For the first time since Fidel Castro took power in Cuba over a half-century ago, a drug developed by the Communist regime is going through clinical trials in the United States. http://www.physorg.com/news171277649.html Medicine & Health Fri, 04 Sep 2009 10:30:02 EST news171277649 The targeted therapy Avastin, alone and in combination with the chemotherapy drug CPT-11, significantly increased response rates, progression-free survival times and survival rates in patients with a deadly form of brain cancer that had recurred. http://www.physorg.com/news171125893.html Medicine & Health Wed, 02 Sep 2009 16:10:04 EST news171125893 (PhysOrg.com) -- Scientists from the U.S. Department of Energy's Argonne National Laboratory and the University of Chicago's Brain Tumor Center have developed a way to target brain cancer cells using inorganic titanium dioxide nanoparticles bonded to soft biological material. http://www.physorg.com/news169904314.html Nanotechnology Wed, 19 Aug 2009 12:39:03 EST news169904314 Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM). In a move toward therapy, the researchers showed that a small designer protein can block this activity and reduce the spreading of GBM cells grown in the laboratory. http://www.physorg.com/news169820163.html Medicine & Health Tue, 18 Aug 2009 13:50:03 EST news169820163 Researchers from Columbia University Medical Center's Herbert Irving Comprehensive Cancer Center have identified a protein that activates brain stem cells to make new neurons - but that may be hijacked later in life to cause brain cancer in humans. The protein called Huwe1 normally functions to eliminate other unnecessary proteins and was found to act as a tumor suppressor in brain cancer. http://www.physorg.com/news169735638.html Medicine & Health Mon, 17 Aug 2009 14:00:01 EST news169735638 The observation that people taking medication for schizophrenia have lower cancer rates than other people has prompted new research revealing that anti-psychotic drugs could help treat some major cancers. http://www.physorg.com/news169297081.html Medicine & Health Wed, 12 Aug 2009 12:10:03 EST news169297081 In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation. The researchers report that STAT3 could become a target for cancer therapy, specifically in Glioblastoma multiforme (GBM), a type of malignant and aggressive brain tumor. http://www.physorg.com/news169120154.html Medicine & Health Mon, 10 Aug 2009 10:49:38 EST news169120154 Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer. http://www.physorg.com/news168706119.html Medicine & Health Wed, 05 Aug 2009 16:10:02 EST news168706119 Brain cancer is among the deadliest of cancers. It's also one of the hardest to treat. Imaging results are often imprecise because brain cancers are extremely invasive. Surgeons must saw through the skull and safely remove as much of the tumor as they can. Then doctors use radiation or chemotherapy to destroy cancerous cells in the surrounding tissue. http://www.physorg.com/news168537401.html Nanotechnology Mon, 03 Aug 2009 17:20:01 EST news168537401 Cancer researchers at Georgetown University's Lombardi Comprehensive Cancer Center have successfully tested a small, engineered antibody they say shuts down growth of human glioblastoma tumors in cell and animal studies. Glioblastoma is the deadliest of brain cancers; there is no effective treatment. http://www.physorg.com/news168253487.html Medicine & Health Fri, 31 Jul 2009 10:05:36 EST news168253487 The incidence of a rare and deadly tumor called primary central nervous system lymphoma (PCNSL) is two times higher in black Americans, ages 20 to 49, than in white Americans, according to a Mayo Clinic study published in the June issue of Journal of Neuro-Oncology. In patients older than 49, the results were reversed. White Americans were twice as likely as black Americans to be diagnosed with PCNSL. http://www.physorg.com/news168190695.html Medicine & Health Thu, 30 Jul 2009 17:10:01 EST news168190695 UCLA researchers have uncovered a new way to scan brain tumors and predict which ones will be shrunk by the drug Avastin -- before the patient ever starts treatment. By linking high water movement in tumors to positive drug response, the UCLA team predicted with 70 percent accuracy which patients' tumors were the least likely to grow six months after therapy. http://www.physorg.com/news168151138.html Medicine & Health Thu, 30 Jul 2009 06:10:02 EST news168151138 (AP) -- Scientists have found seven key genes in the type of brain tumor affecting Sen. Edward Kennedy that together can predict how aggressive a patient's cancer will be. http://www.physorg.com/news166809744.html Medicine & Health Tue, 14 Jul 2009 17:03:07 EST news166809744 As survival rates among some patients with cancer continue to rise, so does the spread of these cancers to the brain - as much as 40 percent of all diagnosed brain cancers are considered metastatic, having spread from a primary cancer elsewhere in the body. http://www.physorg.com/news163700779.html Medicine & Health Mon, 08 Jun 2009 17:26:57 EST news163700779 A national Radiation Therapy Oncology Group (RTOG) study led by a Medical College of Wisconsin Cancer Center physician at Froedtert Hospital in Milwaukee has found that a course of radiation therapy to the brain after treatment for locally advanced non-small cell lung cancer reduced the risk of metastases to the brain within the first year after treatment. The study was presented at the American Society of Clinical Oncology annual meeting in Orlando, June 1. http://www.physorg.com/news163270794.html Medicine & Health Wed, 03 Jun 2009 18:00:15 EST news163270794 University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more effective future treatments and a way to screen for the disease early. http://www.physorg.com/news163077804.html Medicine & Health Mon, 01 Jun 2009 12:24:13 EST news163077804 An experimental drug derived from cottonseed shows promise in treating the recurrence of glioblastoma multiforme, widely considered the most lethal brain cancer, said researchers at the University of Alabama at Birmingham (UAB). http://www.physorg.com/news162725213.html Medicine & Health Thu, 28 May 2009 10:31:50 EST news162725213 (PhysOrg.com) -- An unlikely multidisciplinary scientific collaboration has discovered that an electronic nose developed for air quality monitoring on Space Shuttle Endeavour can also be used to detect odour differences in normal and cancerous brain cells. The results of the pilot study open up new possibilities for neurosurgeons in the fight against brain cancer. http://www.physorg.com/news160282996.html Medicine & Health Thu, 30 Apr 2009 04:03:40 EST news160282996 Cancer that spreads to other organs finds a particularly inviting hideout in the brain, where these metastases are usually far harder to treat than they are in other locations. Two researchers from The University of Texas M. D. Anderson Cancer Center discussed ways to more successfully target these tumors in their "sanctuary" at the American Association for Cancer Research 100th Annual Meeting 2009 in Denver. http://www.physorg.com/news159372220.html Medicine & Health Sun, 19 Apr 2009 15:04:04 EST news159372220 Researchers at the Translational Genomics Research Institute (TGen) may have found a way to stop the often-rapid spread of deadly brain tumors. http://www.physorg.com/news159193588.html Medicine & Health Fri, 17 Apr 2009 13:26:55 EST news159193588 Scientists have found evidence to suggest that ‘small molecule` drugs could offer the first effective chemotherapy for childhood low-grade astrocytomas, improving the prognosis for hundreds diagnosed with the disease - reveals research published today in The Journal of Pathology. http://www.physorg.com/news159113256.html Medicine & Health Thu, 16 Apr 2009 15:10:28 EST news159113256 By combining nanoparticles with a scorpion venom compound already being investigated for treating brain cancer, University of Washington researchers found they could cut the spread of cancerous cells by 98 percent, compared to 45 percent for the scorpion venom alone. http://www.physorg.com/news159108900.html Nanotechnology Thu, 16 Apr 2009 13:56:10 EST news159108900