http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Higher-than-normal levels of insulin place postmenopausal women at increased risk of breast cancer, researchers at Albert Einstein College of Medicine of Yeshiva University report. Their findings, published in the January 7 issue of the Journal of the National Cancer Institute, suggest that interventions that target insulin and its signaling pathways may decrease breast cancer risk in these women. http://www.physorg.com/news150781398.html Medicine & Health Sat, 10 Jan 2009 03:43:18 EST news150781398 The molecular details of Aromatase, the key enzyme required for the body to make estrogen, are no longer a mystery thanks to the structural biology work done by the Ghosh lab at the Hauptman-Woodward Medical Research Institute (HWI) in Buffalo, New York. Dr. Debashis Ghosh's solution of the three-dimensional structure of aromatase is the first time that scientists have been able to visualize the mechanism of synthesizing estrogen. http://www.physorg.com/news150556571.html Medicine & Health Wed, 07 Jan 2009 13:16:11 EST news150556571 A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in 30 to 40 percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death. http://www.physorg.com/news150382922.html Medicine & Health Mon, 05 Jan 2009 13:02:02 EST news150382922 Throughout the world, 10 million breast cancer survivors have a lifetime risk for developing lymphedema, a chronic condition that involves swelling of the limbs and impacts physical and psychosocial health. Second only to the recurrence of cancer, it is the most dreaded effect of breast cancer treatment. In a new study, University of Missouri researchers found that the risk of developing lymphedema is 40 percent to 60 percent higher in women with body mass index (BMI) classified as overweight or obese compared to normal weight women. The researchers recommend increased health education for breast cancer survivors. http://www.physorg.com/news148818233.html Medicine & Health Thu, 18 Dec 2008 10:23:53 EST news148818233 Good quality extra-virgin olive oil contains health-relevant chemicals, 'phytochemicals', that can trigger cancer cell death. New research published in the open access journal BMC Cancer sheds more light on the suspected association between olive oil-rich Mediterranean diets and reductions in breast cancer risk. http://www.physorg.com/news148795838.html Medicine & Health Thu, 18 Dec 2008 04:10:38 EST news148795838 A secondary analysis of a large, multicenter clinical trial has shown that a diet loaded with fruits, vegetables and fiber and somewhat lower in fat compared to standard federal dietary recommendations cuts the risk of recurrence in a subgroup of early-stage breast cancer survivors - women who didn't have hot flashes - by approximately 31 percent. These patients typically have higher recurrence and lower survival rates than breast cancer patients who have hot flashes. The study team, led by researchers at the Moores Cancer Center at the University of California, San Diego, along with six other sites, including the University of California, Davis, reported its results online December 15, 2008, in the Journal of Clinical Oncology. http://www.physorg.com/news148624645.html Medicine & Health Tue, 16 Dec 2008 04:37:25 EST news148624645 The metastasis or spread of breast cancer to other tissues in the body can be predicted more accurately by examining subnetworks of gene expression patterns in a patient's tumor, than by conventional gene expression microarrays, according to a presentation at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco. http://www.physorg.com/news148571357.html Medicine & Health Mon, 15 Dec 2008 13:49:17 EST news148571357 A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Research. http://www.physorg.com/news148565507.html Medicine & Health Mon, 15 Dec 2008 12:11:47 EST news148565507 Having dense breasts - areas that show up light on a mammogram - is strongly associated with increased breast cancer risk, but "why" remains to be answered. Now, by examining dense and non-dense tissue taken from the breasts of healthy volunteers, researchers from Mayo Clinic have found several potential links. http://www.physorg.com/news148488226.html Medicine & Health Sun, 14 Dec 2008 14:43:46 EST news148488226 A type of benign breast disease (BBD) known as atypical hyperplasia substantially increases a young woman's risk of developing breast cancer, even if there is no history of breast cancer in her family, say researchers at Mayo Clinic. http://www.physorg.com/news148488167.html Medicine & Health Sun, 14 Dec 2008 14:42:47 EST news148488167 An interim analysis of a breast cancer prevention study using exemestane (Aromasin(R)) finds an "acceptable" level of bone loss. http://www.physorg.com/news148488121.html Medicine & Health Sun, 14 Dec 2008 14:42:01 EST news148488121 Expression of the microtubule-binding protein Tau is not a reliable means of selecting breast cancer patients for adjuvant paclitaxel chemotherapy, according to research led by The University of Texas M. D. Anderson Cancer Center. http://www.physorg.com/news148453038.html Medicine & Health Sun, 14 Dec 2008 04:57:18 EST news148453038 Research out of the Ireland Cancer Center of University Hospitals Case Medical Center has found that the vast majority of triple negative breast cancers express the MUC-1 target. This first-of-its-kind finding, presented today at the San Antonio Breast Cancer Symposium, has paved the way for an upcoming vaccine trial for patients with early stage triple negative breast cancer that could potentially prevent recurrence of this aggressive type of breast cancer. http://www.physorg.com/news148315876.html Medicine & Health Fri, 12 Dec 2008 14:51:16 EST news148315876 Early-stage breast cancer patients with HER2 positive tumors one centimeter or smaller are at significant risk of recurrence of their disease, compared to those with early-stage disease who do not express the aggressive protein, according to a study led by researchers at The University of Texas M. D. Anderson Cancer Center. http://www.physorg.com/news148315554.html Medicine & Health Fri, 12 Dec 2008 14:45:54 EST news148315554 Two separate meta-analyses of clinical trials from around the world that tested tamoxifen against aromatase inhibitor drugs in postmenopausal women with early breast cancer have each reached the same conclusion: aromatase inhibitors are more effective in preventing breast cancer from coming back. Patients using aromatase inhibitors had more than a 3 percent lower cancer recurrence 6-8 years after diagnosis, compared to women using tamoxifen alone. http://www.physorg.com/news148236483.html Medicine & Health Thu, 11 Dec 2008 16:48:03 EST news148236483 For breast cancer survivors, the idea of taking estrogen pills is almost a taboo. In fact, their doctors give them drugs to get rid of the hormone because it can fuel the growth of breast cancer. So these women would probably be surprised by the approach taken by breast cancer physician Matthew Ellis, M.B., Ph.D., associate professor of medicine at Washington University School of Medicine in St. Louis - he has demonstrated that estrogen therapy can help control metastatic breast cancer. http://www.physorg.com/news148227949.html Medicine & Health Thu, 11 Dec 2008 14:25:49 EST news148227949 Mayo Clinic researchers have discovered that a chemical known as endoxifen appears to be the primary metabolite responsible for the effectiveness of tamoxifen in treating breast cancer, and that it works against cancer in an entirely unexpected way. http://www.physorg.com/news148225168.html Medicine & Health Thu, 11 Dec 2008 13:39:28 EST news148225168 Nonhormonal treatment regimens, including anthracycline-based regimens and taxanes, have improved overall survival in women with advanced (metastatic or recurrent inoperable) breast cancer over the last 35 years, according to a systematic review published December 9 in the Journal of the National Cancer Institute. http://www.physorg.com/news148067994.html Medicine & Health Tue, 09 Dec 2008 17:59:54 EST news148067994 A new study from researchers at the University of Michigan Comprehensive Cancer Center found that a tool commonly used by doctors to estimate the risk of a woman's breast cancer returning after surgery is not very effective at explaining risk to patients. As a result, women with breast cancer may not find these tools helpful when deciding whether to have chemotherapy. http://www.physorg.com/news147967883.html Medicine & Health Mon, 08 Dec 2008 14:11:23 EST news147967883 In an important finding published online in Developmental Cell, researchers at Albert Einstein College of Medicine of Yeshiva University, along with collaborators at Massachusetts Institute of Technology, have identified a protein likely responsible for causing breast cancer to spread. http://www.physorg.com/news147965845.html Medicine & Health Mon, 08 Dec 2008 13:37:25 EST news147965845 Tamoxifen may worsen breast cancer in a small subset of patients. Research published in BioMed Central's open access journal Breast Cancer Research suggests that in patients who show reduced or absent expression of the protein E-cadherin, commonly used anti-oestrogen drugs such as tamoxifen may promote more harmful cancer cell behaviour. http://www.physorg.com/news147587111.html Medicine & Health Thu, 04 Dec 2008 04:25:11 EST news147587111 Breast-specific gamma imaging (BSGI) is effective in the detection of cancers not found on mammograms or by clinical exam, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA). http://www.physorg.com/news147531067.html Medicine & Health Wed, 03 Dec 2008 12:51:07 EST news147531067 (PhysOrg.com) -- An anti-cancer compound found in broccoli and cabbage works by lowering the activity of an enzyme associated with rapidly advancing breast cancer, according to a University of California, Berkeley, study appearing this week in the online early edition of the journal Proceedings of the National Academy of Sciences. http://www.physorg.com/news147530697.html Medicine & Health Wed, 03 Dec 2008 12:44:57 EST news147530697 A study has found that positron emission mammography (PEM), a new technique for imaging the breast, is not affected by either breast density or a woman's hormonal status, two factors that limit the effectiveness of standard mammography and MRI at detecting cancer. Results will be presented today at the annual meeting of the Radiological Society of North America (RSNA). http://www.physorg.com/news147455088.html Medicine & Health Tue, 02 Dec 2008 15:44:48 EST news147455088 Findings published in the December 1, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, show lapatinib benefits women with HER2-positive breast cancer, while women with HER2-negative breast cancer or those who express EGRF alone derive no incremental benefit. In addition, a misclassification of metastatic breast cancer patients by as much as 10 percent prevents some people from receiving optimal therapy. http://www.physorg.com/news147443771.html Medicine & Health Tue, 02 Dec 2008 12:36:11 EST news147443771 Once-promising drugs that were abandoned in the fight against breast cancer still could be effective in obese patients, new research suggests. http://www.physorg.com/news147374919.html Medicine & Health Mon, 01 Dec 2008 17:28:39 EST news147374919 A new analysis of the National Cancer Institute's cancer registry has found that as many as one in five older women experience delayed or incomplete radiation treatment following breast-conserving surgery, and that this suboptimal care can lead to worse outcomes. http://www.physorg.com/news147372503.html Medicine & Health Mon, 01 Dec 2008 16:48:23 EST news147372503 A stunning discovery based on epigenetics (the inheritance of propensities acquired in the womb) reveals that consuming choline -a nutrient found in eggs and other foods -during pregnancy may significantly affect breast cancer outcomes for a mother's offspring. This finding by a team of biologists at Boston University is the first to link choline consumption during pregnancy to breast cancer. It also is the first to identify possible choline-related genetic changes that affect breast cancer survival rates. http://www.physorg.com/news147357177.html Medicine & Health Mon, 01 Dec 2008 12:32:57 EST news147357177 Mammography and sonography findings help doctors identify and appropriately treat breast cancer in men, according to a study performed at the University of Texas M.D. Cancer Center in Houston, TX. http://www.physorg.com/news147357120.html Medicine & Health Mon, 01 Dec 2008 12:32:00 EST news147357120 Women with early-stage breast cancer who have undergone breast augmentation may be treated successfully with a partial-breast radiation treatment called brachytherapy, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA). Patients treated with brachytherapy have better cosmetic outcomes and avoid the risk of the implant hardening, compared to patients who undergo whole-breast radiation therapy. http://www.physorg.com/news147355452.html Medicine & Health Mon, 01 Dec 2008 12:04:12 EST news147355452