http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell. http://www.physorg.com/news178377136.html Medicine & Health Wed, 25 Nov 2009 13:30:02 EST news178377136 Researchers at the Burnham Institute for Medical Research have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in cancer cell migration and tumor metastasis. Sara Courtneidge, Ph.D., professor and director of the Tumor Microenvironment Program at Burnham's NCI-designated Cancer Center, and colleagues have found that inhibiting reactive oxygen reduces invadopodia formation and limits cancer cell invasion. The study was published on September 15 in the journal Science Signaling. http://www.physorg.com/news172313995.html Medicine & Health Wed, 16 Sep 2009 10:00:32 EST news172313995 A new study identifies a molecule that acts cooperatively with a well known oncoprotein to drive progression of noninvasive breast cancer to metastatic, life-threatening disease. The research findings, published by Cell Press in the September issue of the journal Cancer Cell, could have a significant impact on therapeutic decisions by facilitating identification of high risk patients. http://www.physorg.com/news171633603.html Medicine & Health Tue, 08 Sep 2009 13:00:41 EST news171633603 Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM). In a move toward therapy, the researchers showed that a small designer protein can block this activity and reduce the spreading of GBM cells grown in the laboratory. http://www.physorg.com/news169820163.html Medicine & Health Tue, 18 Aug 2009 13:50:03 EST news169820163 Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These glycans play a critical role in cell adhesion in normal cells, and their decrease or loss leads to increased cell migration by invasive cancer cells and metastasis. An increase in expression of the enzyme that produces these glycans, β3GnT1, resulted in a significant reduction in tumor activity. http://www.physorg.com/news166120789.html Medicine & Health Mon, 06 Jul 2009 18:30:01 EST news166120789 Research led by David Worthylake, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, may help lay the groundwork for the development of a compound to prevent the spread of cancer. The research will be published in the May 29, 2009 issue of the Journal of Biological Chemistry. http://www.physorg.com/news162132055.html Chemistry Thu, 21 May 2009 13:41:33 EST news162132055 Migration of colonic lamina propria fibroblasts (CLPF) plays an important role during the progression of fibrosis and fistulae in Crohn's disease. Transforming growth factor- beta (TGF- beta) is involved in the regulation of cell migration, cell differentiation, extracellular matrix deposition, and immune responses. Since the regulation of migration and differentiation of intestinal fibroblasts is an important mechanism during intestinal wound healing and fibrosis, it is important to investigate the effect of TGF- beta 1 on these processes and on fibronectin (FN) and FN isoform production. http://www.physorg.com/news157637926.html Medicine & Health Mon, 30 Mar 2009 13:19:20 EST news157637926 Researchers from Thomas Jefferson University have identified a protein that appears to play a significant role in the growth and migration of prostate cancer cells, especially androgen-independent prostate cancer cells. The study was published in the American Journal of Pathology. http://www.physorg.com/news154879728.html Medicine & Health Thu, 26 Feb 2009 14:09:18 EST news154879728 Tumors that are about to progress and metastasize go through a process also seen in normal embryonic development, known as the epithelial to mesenchymal transition (EMT). Tumor cells revert to a less-differentiated state, stop adhering to each another and become more mobile and prone to invade and proliferate. Now, researchers at Children's Hospital Boston show, for the first time, that a small protein called lipocalin 2 triggers the EMT in human breast cancer - and that the same protein, when measured in tissues and urine, can predict a cancer's invasiveness. Their findings were published online February 23 by the Proceedings of the National Academy of Sciences. http://www.physorg.com/news154632578.html Medicine & Health Mon, 23 Feb 2009 17:30:13 EST news154632578 Scientists from the Scripps Research Institute and the Genomics Institute of the Novartis Research Foundation have found a specific mutation that leads to the development of severe autoimmune kidney disease in mice. The research sheds light on the basic biology of the immune system, as well as on the effectiveness of drugs such as the anti-leukemia medication Gleevec/Imatinib. http://www.physorg.com/news151343235.html Medicine & Health Fri, 16 Jan 2009 15:47:15 EST news151343235 One of the defining characteristics of cancer cells is that they systematically prevent programmed cell death (apoptosis), with which the body guards itself against the proliferation of defective cells. In order to do this, they express so-called apoptosis inhibitors (IAPs) among other proteins. http://www.physorg.com/news147367497.html Medicine & Health Mon, 01 Dec 2008 15:24:57 EST news147367497 (PhysOrg.com) -- One of the problems with laser surgery is that the heat produced can damage tissue, and even lead to cell death. Attempts are being made to replace laser surgery with non-thermal plasma interaction, potentially allowing for the possibility of single cell removal without affecting the surrounding cells and tissue. While this specific use is for the future, important steps are being taken now to further study the interaction between non-thermal atmospheric (room temperature) plasma and living tissue. http://www.physorg.com/news146829160.html Physics Tue, 25 Nov 2008 09:52:40 EST news146829160 The mysterious process that orchestrates cells to move in unison to form human and animal embryos, heal wounds, and even spread cancer depends on interaction between two well-known genetic signaling pathways, two University of Utah medical school researchers have discovered. http://www.physorg.com/news145542766.html Medicine & Health Mon, 10 Nov 2008 12:32:46 EST news145542766