http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- A Cornell study shows the protein not only activates some genes involved in the regulation of cell growth and signaling, but also may play a role in preventing cancers by inhibiting cell proliferation. http://www.physorg.com/news180633805.html Medicine & Health Mon, 21 Dec 2009 16:04:13 EST news180633805 (PhysOrg.com) -- Researchers at McGill University have identified a protein that plays a key role in cell proliferation and is likely to promote cancer development. The work may lead to the development of new diagnostic tools adjusted for personalized treatments, the researchers said. Their results are published in the journal Proceedings of the National Academy of Sciences (PNAS). http://www.physorg.com/news180033486.html Chemistry Mon, 14 Dec 2009 17:20:27 EST news180033486 Duke University Medical Center researchers have figured out how stem cells in the malignant brain cancer glioma may be better able to resist radiation therapy. And using a drug to block a particular signaling pathway in these cancer stem cells, they were able to kill many more glioma cells with radiation in a laboratory experiment. http://www.physorg.com/news178983338.html Medicine & Health Wed, 02 Dec 2009 13:41:28 EST news178983338 Although the chances of surviving advanced melanoma aren't very good with current therapies, some patients can live for years with cancer that has spread beyond the skin to other organs. Now it may be possible to identify which patients are more likely to survive by analyzing the activity of hundreds of genes involved in the immune response and gene proliferation, according to researchers at NYU Langone Medical Center. http://www.physorg.com/news177008484.html Medicine & Health Mon, 09 Nov 2009 17:50:05 EST news177008484 Two genes, each one of which is known to cause cancer on its own, together can lead to aggressive leukaemia. This is the conclusion from new research carried out on gene-modified mice at the Sahlgrenska Academy at the University of Gothenburg, Sweden. The discovery has surprised scientists, and may lead to new treatments. http://www.physorg.com/news176465080.html Medicine & Health Tue, 03 Nov 2009 10:20:01 EST news176465080 Penn State College of Medicine researchers, in collaboration with colleagues at the University of Southern California, have taken an important step in understanding the role of stem cells in development of liver cancer. Using a unique approach that involves study of individual cells, the team, led by C. Bart Rountree, M.D., has demonstrated for the first time a population of cancer stem cells in the liver prior to tumor formation. The research, published in the journal Stem Cells, shows a potential link between liver stem cells and liver cancer. http://www.physorg.com/news172424170.html Medicine & Health Thu, 17 Sep 2009 16:50:02 EST news172424170 The molecular mechanisms of tungstate activity in diabetes have been uncovered. Researchers writing in the open access journal BMC Genomics have identified the pathways through which sodium tungstate improves pancreatic function and beta cell proliferation. http://www.physorg.com/news170620519.html Medicine & Health Thu, 27 Aug 2009 20:10:02 EST news170620519 Research published by Army scientists indicates that a minor reduction in levels of one particular gene, known as CD45, can provide protection against two divergent microbes: the virus that causes Ebola hemorrhagic fever and the bacterium that causes anthrax. Taken together, the results suggest a common host restriction factor and a promising approach to drug development for treating two completely different infections. http://www.physorg.com/news170002817.html Biology Thu, 20 Aug 2009 16:01:30 EST news170002817 Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade surrounding tissues. The study was published in the journal Cancer Research on June 15. http://www.physorg.com/news167659729.html Medicine & Health Fri, 24 Jul 2009 13:40:01 EST news167659729 Researchers from the Kimmel Cancer Center at Jefferson have identified a protein relationship that may be an ideal treatment target for ER+ breast cancer. The study was reported in the July 15 issue of Cancer Research. http://www.physorg.com/news166879002.html Medicine & Health Wed, 15 Jul 2009 12:17:14 EST news166879002 (PhysOrg.com) -- In the developing fetus, cell growth follows a very specific schedule. In the eye's retina, for example, cones -- which help distinguish color during the day -- develop before the more light-sensitive rods -- which are needed for night vision. http://www.physorg.com/news162057067.html Biology Wed, 20 May 2009 16:51:42 EST news162057067 Researchers comparing the fetal development of the eye of the owl monkey with that of the capuchin monkey have found that only a minor difference in the timing of cell proliferation can explain the multiple anatomical differences in the two kinds of eyes. http://www.physorg.com/news161886881.html Biology Mon, 18 May 2009 17:37:46 EST news161886881 Our genome is a patchwork of neighborhoods that couldn't be more different: Some areas are hustling and bustling with gene activity, while others are sparsely populated and in perpetual lock-down. Breaking down just a few of the molecular fences that separate them blurs the lines and leads to the inactivation of at least two tumor suppressor genes, according to researchers at the Salk Institute for Biological Studies. http://www.physorg.com/news161527703.html Medicine & Health Thu, 14 May 2009 13:50:04 EST news161527703 Attempts to treat critical limb ischemia in peripheral arterial disease (PAD) patients with below-the-knee angioplasty are still thwarted by restenosis (the re-narrowing of the artery at the site of angioplasty or stenting), the need for repeat treatments and the continued progression of atherosclerotic disease, leading to tissue death (gangrene) and amputation. Interventional radiologists have been studying a potential solution -the use of drug-eluting stents -and have found that these types of stents lessened the rate of repeat procedures to open these small arteries, according to results presented at the Society of Interventional Radiology's 34th Annual Scientific Meeting. http://www.physorg.com/news155930480.html Medicine & Health Tue, 10 Mar 2009 19:02:16 EST news155930480 Patients who undergo liver transplantation for hepatitis B-related liver damage should receive lifelong antiviral treatment to keep the disease from coming back. A new study shows that they lack cellular immunity against the disease, making recurrence likely if antiviral treatment is withdrawn. These findings are in the March issue of Liver Transplantation. http://www.physorg.com/news154875581.html Medicine & Health Thu, 26 Feb 2009 13:03:46 EST news154875581 Genes that inhibit the spontaneous development of cancer are called tumor suppressor genes. One of the major tumor suppressors is p53, a protein that acts in the cell nucleus to control the expression of other genes whose products can inhibit cell proliferation (increase in cell number) and cell growth (increase in cell size). Abnormal cell proliferation and growth are characteristics of cancer. Scientists previously knew which p53 target genes inhibit cell proliferation, but those required for inhibition of cell growth were unknown. http://www.physorg.com/news137335704.html Medicine & Health Thu, 07 Aug 2008 13:48:24 EST news137335704 Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of imiquimod, a clinically important immune response modifier with potent antiviral and antitumor activity, is dependent on the Opioid Growth Factor (OGF)-OGF receptor (OGFr) axis for its action. http://www.physorg.com/news136123162.html Medicine & Health Thu, 24 Jul 2008 12:59:22 EST news136123162