http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Many people who are overweight or obese develop insulin resistance and type 2 diabetes at some stage in their lives. A European research team has now discovered that obese people have large amounts of the molecule CXCL5, produced by certain cells in fatty tissue. http://www.physorg.com/news178279547.html Medicine & Health Tue, 24 Nov 2009 10:30:01 EST news178279547 In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease. http://www.physorg.com/news177515874.html Medicine & Health Sun, 15 Nov 2009 13:59:14 EST news177515874 (PhysOrg.com) -- MIT cancer biologists have identified a subpopulation of cells that can give rise to pancreatic cancer. They also found that tumors can form in other, more mature pancreatic cell types, but only when they are injured or inflamed, suggesting that pancreatic cancer can arise from different types of cells depending on the circumstances. http://www.physorg.com/news176386790.html Medicine & Health Mon, 02 Nov 2009 12:20:27 EST news176386790 Macrophages, the scavenger cells of the body's immune system, are responsible for disposing of dying cells. Stanford University School of Medicine researchers have identified one pathway in this important process in mice that, if disrupted, causes a lupuslike autoimmune disease. http://www.physorg.com/news175093362.html Medicine & Health Sun, 18 Oct 2009 14:03:19 EST news175093362 A recent study maps the pathway that leads from infection with Hepatitis B and C virus (HBV and HCV) to chronic hepatitis and liver cancer and proposes a new therapeutic strategy for treating liver diseases with chronic inflammation. The research, published by Cell Press in the October issue of the journal Cancer Cell, describes a signaling pathway that can be beneficial during liver regeneration, but can lead to chronic hepatitis and severe liver damage when chronically activated. The research was performed in the Department of Pathology, Institutes of Clinical Pathology and Neuropathology at the University Hospital in Zurich. http://www.physorg.com/news173968463.html Medicine & Health Mon, 05 Oct 2009 14:10:08 EST news173968463 A new study led by Mayo Clinic researchers has found that ulcerative colitis patients had a 41 percent reduction in colectomy after a year when treated with infliximab, according to a study published in the October 2009 issue of Gastroenterology. http://www.physorg.com/news173595232.html Medicine & Health Thu, 01 Oct 2009 06:20:01 EST news173595232 According to the National Center for Chronic Disease Prevention and Health Promotion, 46 million Americans have arthritis. Many of these people take over-the-counter anti-inflammatory medications that block production of certain molecules, known as bioactive lipids, to reduce pain and swelling. http://www.physorg.com/news171050614.html Chemistry Tue, 01 Sep 2009 19:20:01 EST news171050614 Researchers may have found a key ingredient in the recipe that leads from obesity to chronic low-grade inflammation, according to a report in the September issue of Cell Metabolism. http://www.physorg.com/news171028922.html Medicine & Health Tue, 01 Sep 2009 13:20:01 EST news171028922 Heart attacks and strokes -- the leading causes of death in the United States and other developed countries -- may have been rare for the vast majority of human history, suggests a study to be published in PLoS ONE on Tuesday, August 11. http://www.physorg.com/news169187456.html Medicine & Health Tue, 11 Aug 2009 05:31:22 EST news169187456 Gastroesophageal reflux diseases , or GERD, affects about 10 million people in the United States, yet the cause and an unexpected increase in its prevalence over the last three decades remains unexplainable. Now, researchers have discovered that GERD is associated with global alteration of the microbiome in the esophagus. The findings, reported in the August 1, 2009 issue of Gastroenterology, may provide for the foundation for further study of the condition as a microecological disease with new treatment possibilities. http://www.physorg.com/news168324396.html Medicine & Health Sat, 01 Aug 2009 06:50:01 EST news168324396 Immigration officials held a cancer patient for four hours before they allowed him to enter the USA because one of his cancer drugs caused his fingerprints to disappear. His oncologist is now advising all cancer patients who are being treated with the commonly used drug, capecitabine, to carry a doctor's letter with them if they want to travel to the USA. http://www.physorg.com/news162626394.html Medicine & Health Wed, 27 May 2009 07:00:34 EST news162626394 A team of researchers has found an association between breast cancer survival and two proteins that, when present in the blood in high levels, are indicators of inflammation. Using data from the Health, Eating, Activity and Lifestyle (HEAL) study sponsored by the National Cancer Institute, part of the National Institutes of Health, the researchers found that breast cancer patients with elevated levels of C-reactive protein (CRP) and serum amyloid A (SAA) were approximately two to three times more likely to die sooner or have their cancer return than those patients who had lower levels of these proteins, regardless of the patient's age, tumor stage, race, body mass index, or history of previous cardiovascular issues. The results of this study were published online, May 26, 2009, in the Journal of Clinical Oncology. http://www.physorg.com/news162573606.html Medicine & Health Tue, 26 May 2009 16:21:40 EST news162573606 The colorectal cancer is thought to be resulted from a combination of environmental factors, diet, lifestyle, chronic inflammation and accumulation of specific genetic alterations. The pathogenesis and development of colorectal cancer involve multi-genes and multi-steps. TSPAN1 (GenBank Accession No. AF065388) is a new member of TM4SF located at chromosome 1 p34.1. It encodes a 241 amino acid protein. TSPAN1 was reported as a tumor-related gene recently. http://www.physorg.com/news162213544.html Medicine & Health Fri, 22 May 2009 12:19:27 EST news162213544 Heliobacter pylori (H. pylori) infection is considered one of the most important risk factors for stomach (or gastric) cancer with as much as 65% of all cases linked back to the bacteria, although exactly how this occurs is not fully clear. But now researchers in Denmark, Portugal and France, publishing in the journal Clinical Cancer Research, show that H. pylori infection contribution to cancer can be linked to at least three independent molecular pathways, which, when disturbed by infection, lead to mutations in the patients` gastric tissues. http://www.physorg.com/news160991589.html Medicine & Health Fri, 08 May 2009 08:54:22 EST news160991589 Chronic inflammation, which is at the root of multiple diseases, links periodontal disease to increased incidence of cardiovascular disease. http://www.physorg.com/news160752916.html Medicine & Health Tue, 05 May 2009 14:35:36 EST news160752916 Michelle Stevens first noticed the red, blotchy patches on her toddler's feet after he started walking. Every time Noah walked outdoors in their grassy backyard, the blotches appeared. http://www.physorg.com/news158435472.html Medicine & Health Wed, 08 Apr 2009 18:51:29 EST news158435472 Researchers at the University of Illinois report that IDO, an enzyme found throughout the body and long suspected of playing a role in depression, is in fact essential to the onset of depressive symptoms sparked by chronic inflammation. http://www.physorg.com/news157737755.html Medicine & Health Tue, 31 Mar 2009 17:03:47 EST news157737755 Diabetes and eczema may appear to be two completely unrelated diseases. But UC San Diego biologists have uncovered what appears to be a crucial biochemical link between the two. http://www.physorg.com/news157136762.html Chemistry Tue, 24 Mar 2009 18:06:42 EST news157136762 Immune cells once thought to be innocent bystanders in cystic fibrosis may hold the key to stopping patients' fatal lung disease. New findings from the Stanford University School of Medicine and Lucile Packard Children's Hospital show that white blood cells called neutrophils respond strongly to conflicting signals from cystic fibrosis patients' lungs, setting up a molecular fracas that may explain the patients' severe lung damage. http://www.physorg.com/news156446148.html Medicine & Health Mon, 16 Mar 2009 18:16:15 EST news156446148 Inflammation, the body's earliest response to damage or infection, can aid the healing process and trigger an immune response against invading pathogens. But inflammation gone awry can also undermine health, as in diseases such as rheumatoid arthritis or asthma. http://www.physorg.com/news155993656.html Biology Wed, 11 Mar 2009 12:35:33 EST news155993656 We usually think of fish as a "heart-healthy" food. Now fish are helping researchers better understand how heart disease develops in studies that could lead to new drugs to slow disease and prevent heart attacks. http://www.physorg.com/news155495877.html Medicine & Health Thu, 05 Mar 2009 17:18:28 EST news155495877 Children with newly diagnosed cases of inflammatory bowel disease have higher concentrations of folate in their blood than individuals without IBD, according to a new study led by researchers at the University of California, San Francisco and UC Berkeley. The findings bring into question the previously held theory that patients with IBD are prone to folate - also known as folic acid - deficiency. http://www.physorg.com/news152011513.html Medicine & Health Sat, 24 Jan 2009 09:30:22 EST news152011513 With up to half of a person's body mass consisting of skeletal muscle, chronic inflammation of those muscles - which include those found in the limbs - can result in significant physical impairment. http://www.physorg.com/news147617766.html Medicine & Health Thu, 04 Dec 2008 12:56:06 EST news147617766 Researchers at the University of California, San Diego School of Medicine, led by Ajit Varki, M.D., have shown a new mechanism for how human consumption of red meat and milk products could contribute to the increased risk of cancerous tumors. Their findings, which suggest that inflammation resulting from a molecule introduced through consumption of these foods could promote tumor growth, are published online this week in advance of print publication in the Proceedings of the National Academy of Sciences (PNAS). http://www.physorg.com/news145814428.html Medicine & Health Thu, 13 Nov 2008 16:00:28 EST news145814428 Arnhem, 13 November 2008 -- In the December issue of European Urology (http://www.elsevier.com/locate/eururo) Dr. Curtis Nickel and associates report on the evidence of a relationship between prostate inflammation and lower urinary tract symptoms (LUTS) in men enrolled in the REDUCE trial. http://www.physorg.com/news145800523.html Medicine & Health Thu, 13 Nov 2008 12:08:43 EST news145800523 A multi-center research team, led by Columbia University Medical Center, has uncovered a major contributor to the cause of stomach cancer - the second leading cause of cancer-related mortality in the world. The team described for the first time, that elevated levels of a single proinflammatory cytokine, an immune system protein called interleukin-1 beta (IL-1β), can start the progression towards stomach cancer. These results are published in the Nov. 4, 2008 issue of Cancer Cell. The researchers hope to use this finding to develop ways to block this process, thereby preventing cancer from developing. http://www.physorg.com/news145109406.html Medicine & Health Wed, 05 Nov 2008 12:10:06 EST news145109406