http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Researchers at Binghamton University, State University of New York, have identified three key regulators required for the formation and development of biofilms. The discovery could lead to new ways of treating chronic infections. http://www.physorg.com/news180369659.html Biology Fri, 18 Dec 2009 14:41:37 EST news180369659 A team of researchers studying the protein that, when defective or absent, causes cystic fibrosis (CF) has made an important discovery about how that protein is normally controlled and under what circumstances it might go awry. http://www.physorg.com/news180339751.html Chemistry Fri, 18 Dec 2009 06:40:01 EST news180339751 An increase in the number of screened carriers for cystic fibrosis (CF) was associated with a decrease in the number of children born with CF in northeast Italy, according to a study in the December 16 issue of JAMA. http://www.physorg.com/news180182798.html Medicine & Health Wed, 16 Dec 2009 11:10:01 EST news180182798 How does a cell manage to identify and degrade the diverse types of defective proteins and thus protect the body against serious diseases? The researchers Sabine C. Horn, Professor Thomas Sommer, Professor Udo Heinemann and Dr. Ernst Jarosch of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, have now found a crucial piece in this puzzle. In an enzyme complex that plays a critical role in the quality control of proteins, they discovered a scaffold regulating the identification and disposal of various defectively produced proteins. http://www.physorg.com/news179757100.html Chemistry Fri, 11 Dec 2009 13:10:02 EST news179757100 In an encouraging new development, a team led by Scripps Research Institute scientists has restored partial function to lung cells collected from patients with cystic fibrosis. While there is still much work to be done before the therapy can be tested in humans, the discovery opens the door to a new class of therapies for this and a host of other chronic diseases. http://www.physorg.com/news179328978.html Chemistry Sun, 06 Dec 2009 13:37:24 EST news179328978 (PhysOrg.com) -- UW researchers have successfully used a method called exome sequencing to quickly discover a previously unknown gene responsible for a rare disorder. The finding demonstrates the usefulness of exome sequencing in studying the 7,000 plus rare genetic disorders affecting millions of people. http://www.physorg.com/news177670903.html Medicine & Health Tue, 17 Nov 2009 09:10:04 EST news177670903 Scientists at the University of Pennsylvania School of Medicine discovered that a dietary antioxidant found in such vegetables as broccoli and cauliflower protects cells from damage caused by chemicals generated during the body's inflammatory response to infection and injury. The finding has implications for such inflammation-based disorders as cystic fibrosis (CF), diabetes, heart disease, and neurodegeneration. http://www.physorg.com/news177612619.html Medicine & Health Mon, 16 Nov 2009 16:50:44 EST news177612619 Scientists in Belgium have successfully differentiated human embryonic stem cells (hESC) into major cell types of lung epithelial tissue using a convenient air-liquid interface. The technique, published in BioMed Central's open access journal Respiratory Research, could provide an alternative to lung transplants for patients with lung injury due to chronic pulmonary disease and inherited genetic diseases such as cystic fibrosis. http://www.physorg.com/news176622987.html Medicine & Health Thu, 05 Nov 2009 05:57:13 EST news176622987 Bacteria that cause chronic lung infections can communicate with each other to form a deadly shield against the body's natural defenses. Studying these interactions could lead to new ways of treating bacteria that are resistant to antibiotics, according to an article in the November issue of Microbiology. http://www.physorg.com/news176352755.html Biology Mon, 02 Nov 2009 02:53:31 EST news176352755 A cellular protein from a family involved in several human diseases is crucial for the proper production and release of insulin, new research has found, suggesting that the protein might play a role in diabetes. http://www.physorg.com/news175787060.html Biology Mon, 26 Oct 2009 14:47:01 EST news175787060 The American Thoracic Society has released new clinical guidelines for the treatment of exacerbations in cystic fibrosis based on a review of the literature on current clinical practices. http://www.physorg.com/news175448719.html Medicine & Health Thu, 22 Oct 2009 17:30:01 EST news175448719 A new Tel Aviv University drug, based on an older generation antibiotic, may provide doctors with an effective and innovative method of treating colon cancer in both its incipient and full-blown stages -- and minimize the need for painful, uncomfortable colonoscopies and surgical polyp removal. http://www.physorg.com/news174647816.html Medicine & Health Tue, 13 Oct 2009 10:18:05 EST news174647816 In the lung, mucus is produced by cells known as goblet cells, which are present in small numbers in the walls of the lungs and airways. http://www.physorg.com/news172170684.html Medicine & Health Mon, 14 Sep 2009 18:11:40 EST news172170684 Researchers from The University of Arizona Colleges of Pharmacy and Medicine are teaming up to try to invent a novel non-invasive lung test for cystic fibrosis sufferers. http://www.physorg.com/news171807753.html Medicine & Health Thu, 10 Sep 2009 13:40:05 EST news171807753 Researchers at the University of North Carolina at Chapel Hill have discovered a genetic risk factor for severe liver disease in people with cystic fibrosis. Those who carry a particular variant of the SERPINA1 gene (also known as alpha-1-antitrypsin or alpha-1-antiprotease) are five times more likely to develop cirrhosis and other liver complications than patients who carry the normal version of the gene. http://www.physorg.com/news171649546.html Medicine & Health Tue, 08 Sep 2009 17:40:02 EST news171649546 In the new era of personalized medicine, physicians hope to provide earlier diagnoses and improve therapy by evaluating patients' genetic blueprints. But, as a new bioinformatics study emphasizes, the first step must be to correctly decipher the deluge of information locked in our DNA and determine its impact on human health. http://www.physorg.com/news171193637.html Medicine & Health Thu, 03 Sep 2009 11:00:07 EST news171193637 Mortality remains high among patients with pulmonary arterial hypertension awaiting lung transplant, despite changes to the allocation system that were designed to reduce mortality and increase the equitable distribution of donor organs, according to new research out of University of California San Francisco. http://www.physorg.com/news170306977.html Medicine & Health Mon, 24 Aug 2009 05:00:03 EST news170306977 Patients with cystic fibrosis (CF) usually experience significant muscle loss, a symptom traditionally considered to be a secondary complication of the devastating genetic disease. However, a recent study by Dr. Basil Petrof reverses the equation: his results show that muscle atrophy and weakness may be a primary symptom caused by the effects of CFTR gene mutations on the muscle itself. Dr. Petrof's findings will be published on July 31 in Public Library of Science -- Genetics. http://www.physorg.com/news168270197.html Medicine & Health Fri, 31 Jul 2009 15:00:01 EST news168270197 In 1989 scientists identified the gene mutation that causes cystic fibrosis (CF), which led to the hope that CF lung disease could be 'cured' using gene therapy. The premise of gene therapy is that modified viruses or other gene-based systems could be used to deliver a corrected version of a gene into affected tissues. However, the projected cure has been hampered by the natural ability of the lung to limit the introduction of foreign genes into its cells. http://www.physorg.com/news167375993.html Medicine & Health Tue, 21 Jul 2009 06:40:01 EST news167375993 Cystic fibrosis medicines that help to break down mucus in the lungs may carry an unexpected long-term benefit, a study suggests. http://www.physorg.com/news166967012.html Medicine & Health Thu, 16 Jul 2009 12:48:12 EST news166967012 (AP) -- Baby Riley Matthews wheezed noisily on the exam table. "He's belly-breathing," the emergency-room doctor said worriedly - Riley's little abdomen was markedly rising and falling with each breath, a sign of respiratory distress. http://www.physorg.com/news166164064.html Medicine & Health Tue, 07 Jul 2009 06:30:01 EST news166164064 An otherwise effective treatment for cystic fibrosis places patients at a high risk of sensorineural hearing loss, according to new research published in the July edition of Otolaryngology-Head and Neck Surgery. http://www.physorg.com/news165645625.html Medicine & Health Wed, 01 Jul 2009 05:41:18 EST news165645625 Women with cystic fibrosis can have fertility treatment to help them have babies without any long-term adverse effects on either themselves or their children, according to new research presented at the 25th annual meeting of the European Society of Human Reproduction and Embryology in Amsterdam today. http://www.physorg.com/news165576073.html Medicine & Health Tue, 30 Jun 2009 10:23:50 EST news165576073 More than one kind of stem cell is required to support the upkeep and repair of the lungs, according to a new study published in the journal Cell Stem Cell. http://www.physorg.com/news163343671.html Biology Thu, 04 Jun 2009 14:15:04 EST news163343671 Sections of proteins previously thought to be disordered may in fact have an unexpected biological role - providing certain proteins room to move -- according to a study published by researchers at Fox Chase Cancer Center in this month's issue of the journal Structure. http://www.physorg.com/news162565171.html Biology Tue, 26 May 2009 13:59:57 EST news162565171 Aerosol delivery of antibiotics via nanoparticles may provide a means to improve drug delivery and increase patient compliance, thus reducing the severity of individual illnesses, the spread of epidemics, and possibly even retarding antibiotic resistance. http://www.physorg.com/news161955592.html Nanotechnology Tue, 19 May 2009 12:40:18 EST news161955592 In a recent issue of The Journal of Chemical Physics, published by the American Institute of Physics (AIP), a group of researchers at the University of California, Berkeley and Los Alamos National Laboratory describe the first comprehensive, molecular-level numerical study of gene therapy. Their work should help scientists design new experimental gene therapies and possibly solve some of the problems associated with this promising technique. http://www.physorg.com/news160238845.html Physics Wed, 29 Apr 2009 15:47:50 EST news160238845 Three reports describing advances in cystic fibrosis genetic testing appear in the May 2009 issue of The Journal of Molecular Diagnostics. http://www.physorg.com/news160057199.html Medicine & Health Mon, 27 Apr 2009 13:20:49 EST news160057199 Dartmouth Medical School researchers have devised a novel approach for thwarting the relentless bacterial infections that thrive in the lungs of people with cystic fibrosis (CF), unlocking new possibilities against a tenacious and toxic hallmark of the common genetic disease. http://www.physorg.com/news159792146.html Biology Fri, 24 Apr 2009 11:43:42 EST news159792146 The bacteria responsible for chronic infections in cystic fibrosis patients use one of the sugars on the germs' surface to start building a structure that helps the microbes resist efforts to kill them, new research shows. http://www.physorg.com/news159537486.html Biology Tue, 21 Apr 2009 12:58:29 EST news159537486