http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- Scientists at University College Dublin have solved a chemistry problem which has stumped researchers worldwide for more than a decade. The results have earned the group the cover story of the leading scientific journal, Angewandte Chemie. http://www.physorg.com/news177271522.html Chemistry Thu, 12 Nov 2009 18:20:02 EST news177271522 It's no bigger than a stamp packet but it has the potential to allow rapid development of a new generation of drugs and genetic engineering organisms, and to better control in-vitro fertilization. http://www.physorg.com/news176559811.html Chemistry Wed, 04 Nov 2009 12:24:14 EST news176559811 Scientists have for the first time produced liver cells from adult skin cells using the induced pluripotent stem cell (iPSC) technology. http://www.physorg.com/news175259173.html Medicine & Health Tue, 20 Oct 2009 12:20:01 EST news175259173 While studying an HIV protein that plays an essential role in AIDS progression, researchers at the University of Pittsburgh School of Medicine have discovered compounds that show promise as novel treatments for the disease. http://www.physorg.com/news174664492.html Chemistry Tue, 13 Oct 2009 15:10:03 EST news174664492 Cancer and cell biology experts at the University of Cincinnati (UC) have developed a new mass spectrometry-based tool they say provides more precise, cost-effective data collection for drug discovery efforts. http://www.physorg.com/news172424301.html Chemistry Thu, 17 Sep 2009 17:00:05 EST news172424301 Computational biologists at the University of Pittsburgh School of Medicine have shown that proteins have an intrinsic ability to change shape, and this is required for their biological activity. This shape-changing also allows the small molecules that are attracted to a given protein to select the structure that permits the best binding. That premise could help in drug discovery and in designing compounds that will have the most impact on protein function to better treat a host of diseases. http://www.physorg.com/news169904936.html Chemistry Wed, 19 Aug 2009 13:17:09 EST news169904936 (PhysOrg.com) -- Chemists at the University at Buffalo have used rational drug design to synthesize small, cell-permeable molecules that are effective in vitro against two common types of myotonic muscular dystrophy, a result that has implications for potentially curing muscular dystrophy, as well as other diseases. http://www.physorg.com/news168876812.html Chemistry Fri, 07 Aug 2009 15:30:01 EST news168876812 Researchers at the University of Toronto Institute of Biomaterials and Biomedical Engineering (IBBME) and Princess Margaret Hospital (PMH), led by U of T's Professor J.E. Davies, have made important progress in stem cell research that will allow for numerous applications of multi-faceted stem cells known as mesenchymal stem cells (MSCs). This research will advance the selection of specific cells to target specific diseases, ultimately enabling clinicians to "personalize" treatment for patients. http://www.physorg.com/news168615746.html Biology Tue, 04 Aug 2009 15:00:02 EST news168615746 Understanding the structure of proteins is a vital first step in developing new drugs, but to date, researchers have had difficulty studying the large number of proteins that are normally embedded in the cell membrane, a family of proteins that includes those involved in cancer-related signaling processes. However, using nanoparticles, scientists from the University of Birmingham in the United Kingdom have found a way to preserve membrane proteins intact, enabling detailed analysis of their structure, molecular functions, and interaction with potential anticancer agents. http://www.physorg.com/news167412954.html Nanotechnology Fri, 24 Jul 2009 16:40:01 EST news167412954 A newly identified gene appears to be highly predictive of not only the risk of developing Alzheimer's disease, but also the approximate age at which the disease will begin to manifest itself, according to researchers at Duke University Medical Center. http://www.physorg.com/news166724392.html Medicine & Health Mon, 13 Jul 2009 19:50:01 EST news166724392 Whitehead Institute scientists have developed a rapid, inexpensive drug-screening method that could be used to target diseases that until now have stymied drug developers, such as Parkinson's disease. This technique uses baker's yeast to synthesize and screen the molecules, cutting target discovery and preliminary testing time to a matter of weeks. http://www.physorg.com/news166712777.html Chemistry Mon, 13 Jul 2009 14:06:47 EST news166712777 A new computer model developed at MIT can help solve a problem that has plagued drug companies trying to develop promising new treatments made of antibodies: Such drugs have a relatively short shelf life because they tend to clump together, rendering them ineffective. http://www.physorg.com/news165514408.html Medicine & Health Mon, 29 Jun 2009 17:13:57 EST news165514408 A revolutionary new protein stabilisation technique has been developed by scientists funded by the Biotechnology and Biological Sciences Research Council which could lead to 30 per cent more proteins being available as potential targets for drug development - opening up exciting possibilities in drug discovery. http://www.physorg.com/news165148787.html Nanotechnology Thu, 25 Jun 2009 11:40:17 EST news165148787 Researchers at the University of Texas Medical Branch at Galveston have discovered two biochemical pathways that the Ebola virus relies on to infect cells. Using substances that block the activation of those pathways, they've prevented Ebola infection in cell culture experiments - potentially providing a critical early step in developing the first successful therapy for the deadly virus. http://www.physorg.com/news164997495.html Medicine & Health Tue, 23 Jun 2009 17:39:10 EST news164997495 Researchers from Indiana University-Purdue University Indianapolis (IUPUI) have developed Distributed Drug Discovery (D3), a new low-cost strategy to accelerate the discovery of drugs to treat neglected diseases such as tuberculosis, leprosy, leshmaniasis, dengue fever, and Chagas disease. http://www.physorg.com/news164290841.html Chemistry Mon, 15 Jun 2009 13:21:27 EST news164290841 Crucial breakthroughs in the treatment of many common diseases such as diabetes and Parkinson's could be achieved by harnessing a powerful scientific approach called systems biology, according to leading scientists from across Europe. In a Science Policy Briefing released today by the European Science Foundation, the scientists provide a detailed strategy for the application of systems biology to medical research over the coming years. http://www.physorg.com/news151064787.html Medicine & Health Tue, 13 Jan 2009 10:26:27 EST news151064787 (PhysOrg.com) -- Grid technology developed by European researchers offers a new way to do business, with partners working simply, seamlessly and ‘virtually` around a common goal. It is already having a big impact, in a variety of applications. http://www.physorg.com/news148575326.html Technology Mon, 15 Dec 2008 14:55:26 EST news148575326 Brightly colored beetles or butterfly larvae nibbling on a plant may signal the presence of chemical compounds active against cancer cell lines and tropical parasitic diseases, according to researchers at Smithsonian's Tropical Research Institute in Panama. Such clues could speed drug discovery and provide insight into the ecological relationships between tropical-forest plants and insects that feed on them. The report is published in the Ecological Society of America's journal Frontiers in Ecology and the Environment. http://www.physorg.com/news134756257.html Biology Tue, 08 Jul 2008 17:17:37 EST news134756257