http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- Scientists are closer to understanding how to grow replacement bones with stem cell technology, thanks to research published today in the journal Nature Materials. http://www.physorg.com/news167835469.html Chemistry Sun, 26 Jul 2009 13:58:36 EST news167835469 Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., Sigma-Aldrich Corporation, Open Monoclonal Technology, Inc. (OMT) and INSERM today announced the creation of the first genetically modified mammals developed using zinc finger nuclease (ZFN) technology. http://www.physorg.com/news167579299.html Biology Thu, 23 Jul 2009 15:40:05 EST news167579299 In a paper publishing online July 23 in Cell Stem Cell, a Cell Press journal, Dr. Shaorong Gao and colleagues from the National Institute of Biological Sciences in Beijing, China, report an important advance in the characterization of reprogrammed induced pluripotent stem cells, or iPSCs. http://www.physorg.com/news167569781.html Biology Thu, 23 Jul 2009 12:10:08 EST news167569781 Dental and tissue engineering researchers at Tufts University School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have harnessed the pluripotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic human skin and the oral mucosa (the moist tissue that lines the inside of the mouth). The proof-of-concept study is published online in advance of print in Tissue Engineering Part A. http://www.physorg.com/news167388870.html Medicine & Health Tue, 21 Jul 2009 09:55:05 EST news167388870 Scientists have identified a master regulator gene for early embryonic development of the pancreas and other organs, putting researchers closer to coaxing stem cells into pancreatic cells as a possible cure for type1 diabetes. http://www.physorg.com/news167311578.html Medicine & Health Mon, 20 Jul 2009 12:50:01 EST news167311578 Jordi Garcia Ojalvo -- a lecturer at the Department of Physics and Nuclear Engineering of the Universitat Politčcnica de Catalunya`s School of Industrial and Aeronautical Engineering of Terrassa (ETSEIAT, Spain) -- has discovered the genetic circuit that controls the behavior of embryonic stem cells. The discovery was made in collaboration with University of Cambridge researchers. The process by which a stem cell is transformed into another type of cell is called differentiation, and the ability to change into other cell types is known as pluripotentiality.  http://www.physorg.com/news167289211.html Biology Mon, 20 Jul 2009 06:40:01 EST news167289211 In a new study that could transform embryonic stem cell (ES cell) research, scientists at UT Southwestern Medical Center have discovered why mouse ES cells can be easily grown in a laboratory while other mammalian ES cells are difficult, if not impossible, to maintain. http://www.physorg.com/news166367809.html Biology Thu, 09 Jul 2009 14:17:35 EST news166367809 Scientists have identified a gene that is essential for embryonic stem cells to maintain their all-purpose, pluripotent state. Exploiting the finding may lead to a greater understanding of how cells acquire their specialized states and provide a strategy to efficiently reprogram mature cells back into the pluripotent state, an elusive step in stem cell research but one crucial to a range of potential clinical treatments. http://www.physorg.com/news166279790.html Biology Wed, 08 Jul 2009 13:50:31 EST news166279790 (PhysOrg.com) -- Human sperm have been created using embryonic stem cells for the first time in a scientific development which will lead researchers to a better understanding of the causes of infertility. http://www.physorg.com/news166248285.html Biology Wed, 08 Jul 2009 05:07:07 EST news166248285 Kinarm Ko and Hans Schöler's team at the Max Planck Institute for Molecular Biomedicine in Münster have succeeded for the first time in culturing a clearly defined cell type from the testis of adult mice and converting these cells into pluripotent stem cells without introduced genes, viruses or reprogramming proteins. http://www.physorg.com/news166193480.html Biology Tue, 07 Jul 2009 13:51:54 EST news166193480 The US government on Monday unveiled final rules for embryonic stem cell research, laying out ground rules for "ethically responsible, scientifically worthy" studies eligible for federal funds. http://www.physorg.com/news166163911.html Biology Tue, 07 Jul 2009 06:30:09 EST news166163911 (AP) -- The government is creating a master list of which embryonic stem cells qualify for taxpayer-funded research, now that President Barack Obama has lifted restrictions on the field. http://www.physorg.com/news166106191.html Biology Mon, 06 Jul 2009 13:36:42 EST news166106191 (PhysOrg.com) -- Harvard Stem Cell Institute researchers at Massachusetts General Hospital have identified the earliest master human heart stem cell from human embryonic stem cells - ISL1+ progenitors - that give rise to a family of cells that form the essential portions of the human heart. http://www.physorg.com/news165680045.html Medicine & Health Wed, 01 Jul 2009 15:14:48 EST news165680045 A molecule called telomerase, best known for enabling unlimited cell division of stem cells and cancer cells, has a surprising additional role in the expression of genes in an important stem cell regulatory pathway, say researchers at the Stanford University School of Medicine. The unexpected finding may lead to new anticancer therapies and a greater understanding of how adult and embryonic stem cells divide and specialize. http://www.physorg.com/news165674795.html Medicine & Health Wed, 01 Jul 2009 14:40:03 EST news165674795 The salamander is a superhero of regeneration, able to replace lost limbs, damaged lungs, sliced spinal cord -- even bits of lopped-off brain. But it turns out that remarkable ability isn't so mysterious after all -- suggesting that researchers could learn how to replicate it in people. http://www.physorg.com/news165674643.html Biology Wed, 01 Jul 2009 13:44:38 EST news165674643 (PhysOrg.com) -- When stem cell researchers in Japan and the United States announced in 2007 that they had developed long-sought methods to return fully developed adult human cells to an embryonic-like state, the world of stem cell research was turned upside down. http://www.physorg.com/news165507466.html Biology Mon, 29 Jun 2009 15:18:14 EST news165507466 Dutch researchers have found the first evidence that a process of inactivating the X chromosome during embryo development and implantation, which was known to occur in mice but unknown in humans, does, in fact, take place in human female embryos prior to implantation in the womb. http://www.physorg.com/news165489911.html Medicine & Health Mon, 29 Jun 2009 12:30:02 EST news165489911 (PhysOrg.com) -- Understanding the molecular signals that guide early cells in the embryo to develop into different organs provides insight into ways that tissues regenerate and how stem cells can be used for new therapies. With regenerated cells, researchers hope to one day fill the acute shortage in pancreatic and liver tissue available for transplantation in cases of type I diabetes and acute liver failure. http://www.physorg.com/news165236439.html Biology Fri, 26 Jun 2009 12:01:21 EST news165236439 (PhysOrg.com) -- For years, proponents have touted the benefits of embryonic stem cell research, but the potential therapies still face hurdles. Side effects such as tumor development, a lack of an effective and long-term animal model to test new therapies, and genetic incompatibility between the host and donor cells are some of the problems faced by researchers. http://www.physorg.com/news165157383.html Chemistry Thu, 25 Jun 2009 14:07:52 EST news165157383 Scientists have managed to induce cells from pigs to transform into pluripotent stem cells - cells that, like embryonic stem cells, are capable of developing into any type of cell in the body. It is the first time in the world that this has been achieved using somatic cells (cells that are not sperm or egg cells) from any animal with hooves (known as ungulates). http://www.physorg.com/news163190851.html Biology Tue, 02 Jun 2009 19:48:00 EST news163190851 Once placed into a patient's body, stem cells intended to treat or cure a disease could end up wreaking havoc simply because they are no longer under the control of the clinician. http://www.physorg.com/news162130195.html Biology Thu, 21 May 2009 13:10:32 EST news162130195 (PhysOrg.com) -- When evolution has lucked into efficient solutions for life`s most fundamental problems, it adopts them as invaluable family heirlooms, passing them down as one species evolves into another. So it was reasonable to expect that a key regulator of embryonic development - a strand of RNA that shepherds stem cells through the process of differentiation - might play the same role in all vertebrates, from fish to people. New research, however, has shown that when it comes to microRNAs, what works for one animal may not work the same way in another. http://www.physorg.com/news161613204.html Biology Fri, 15 May 2009 13:34:51 EST news161613204 (PhysOrg.com) -- A new development in stem cell research has resulted from a completed study by a collaboration of scientists using the drug Rapamycin to inhibit mTOR, an intracellular protein necessary in cell proliferation. UCR`s Jiayu Liao, assistant professor in the Department of Bioengineering at Bourns College of Engineering, recently published a paper on the results in the Proceeding of the National Academy of Sciences dealing with human embryonic stem cell pluripotency. http://www.physorg.com/news161612417.html Biology Fri, 15 May 2009 13:20:52 EST news161612417 Stem cells play a role in heart muscle rejuvenation by attracting cells from the body that develop into heart muscle cells. They have been successfully used to halt or reverse cardiac injury following heart attack, but not to prevent injury before it occurs. http://www.physorg.com/news161528262.html Biology Thu, 14 May 2009 13:58:22 EST news161528262 Time is short for scientists to respond to the call for comments on the National Institutes of Health (NIH) proposed guidelines for the use of human embryonic stem (ES) cell lines and their eligibility for federal funds. On May 26, the window to provide feedback will close, and the drafted rules leave the possibility that funding for almost all existing cell lines will disappear. http://www.physorg.com/news161528030.html Biology Thu, 14 May 2009 13:54:33 EST news161528030 (PhysOrg.com) -- Biologists have long wondered why the embryonic heart begins beating so early, before the tissues actually need to be infused with blood. Two groups of researchers from Children's Hospital Boston, Brigham and Women's Hospital, and the Harvard Stem Cell Institute (HSCI) -- presenting multiple lines of evidence from zebrafish, mice and mouse embryonic stem cells -- provide an intriguing answer: A beating heart and blood flow are necessary for development of the blood system, which relies on mechanical stresses to cue its formation. http://www.physorg.com/news161439308.html Medicine & Health Wed, 13 May 2009 13:15:45 EST news161439308 Transplanted embryonic stem cells are recognized as a potential treatment for patients suffering from the effects of spinal cord injury (SCI). However, in studies using embryonic stem cells transplanted into SCI laboratory animals, a serious drawback has been the development of tumors following transplantation. http://www.physorg.com/news161267482.html Medicine & Health Mon, 11 May 2009 13:31:51 EST news161267482 Researchers at the Hebrew University of Jerusalem have discovered a method to potentially eliminate the tumor-risk factor in utilizing human embryonic stem cells. http://www.physorg.com/news160816468.html Medicine & Health Wed, 06 May 2009 08:17:09 EST news160816468 Scientists at UC Santa Barbara have made a significant discovery in understanding the way human embryonic stem cells function. http://www.physorg.com/news160314968.html Biology Thu, 30 Apr 2009 12:56:46 EST news160314968 In a study featured on the cover of the May issue of The FASEB Journal, researchers describe how they are able to reprogram human adult skin cells into other cell types in order to decipher the elusive mechanisms underlying reprogramming. To demonstrate their point, they transformed human skin cells into mouse muscle cells and vice versa. This research shows that by understanding the regulation of cell specialization it may be possible to convert one cell type into another, eventually bypassing stem cells. http://www.physorg.com/news160305025.html Biology Thu, 30 Apr 2009 10:10:41 EST news160305025