http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Investigators at Burnham Institute for Medical Research, the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows nerve cells to communicate with one another) protects the brain from the misfolded proteins associated with Huntington's disease. http://www.physorg.com/news177515236.html Medicine & Health Sun, 15 Nov 2009 13:48:15 EST news177515236 Researchers at the California Institute of Technology (Caltech) have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington's disease in a variety of mouse models. http://www.physorg.com/news176126406.html Medicine & Health Fri, 30 Oct 2009 13:01:53 EST news176126406 The results of a recent study published in PNAS question the long-term effects of transplanted cells in the brains of patients suffering from Huntington's disease. This study, conducted jointly by Dr. Francesca Cicchetti of Université Laval in Quebec, Canada, Dr. Thomas B. Freeman of the University of South Florida, USA, and colleagues provides the first demonstration that transplanted cells fail to offer a long-term replacement for degenerating neurons in patients with Huntington's disease. http://www.physorg.com/news167330808.html Medicine & Health Mon, 20 Jul 2009 18:50:01 EST news167330808 Researchers at the University of Kentucky Markey Cancer Center and Graduate Center for Toxicology (GCT) have gained new insight into the genetic mechanisms underlying Huntington's disease and other neurodegenerative or neuromuscular disorders caused by trinucleotide repeats (or TNRs) in DNA. http://www.physorg.com/news166711425.html Biology Mon, 13 Jul 2009 13:44:27 EST news166711425 Johns Hopkins brain scientists have figured out why a faulty protein accumulates in cells everywhere in the bodies of people with Huntington's disease (HD), but only kills cells in the part of the brain that controls movement, causing negligible damage to tissues elsewhere. The answer, reported this week in Science, lies in one tiny protein called "Rhes" that's found only in the part of the brain that controls movement. The findings, according to the Hopkins scientists, explain the unique pattern of brain damage in HD and its symptoms, as well as offer a strategy for new therapy. http://www.physorg.com/news163344119.html Medicine & Health Thu, 04 Jun 2009 14:22:40 EST news163344119 Researchers from the University of Southern California have taken an important first step toward protecting against Huntington disease using gene therapy. http://www.physorg.com/news159461715.html Chemistry Mon, 20 Apr 2009 15:55:41 EST news159461715 (PhysOrg.com) -- The depression experienced by people with Huntington disease (HD) may have nothing to do with the emotional stress of knowing you have a devastating, incurable disorder, according to a University of British Columbia study published in the journal Brain. http://www.physorg.com/news159200198.html Medicine & Health Fri, 17 Apr 2009 15:17:47 EST news159200198 A global analysis of brain proteins over a 10-week period in a mouse model of Huntington Disease has revealed some new insights into this complex neurodegenerative disorder. For example, profound changes (comparable to those seen in late-stage HD) actually occur well before any disease symptoms show up, and most of the changes are confined to a specific stage during disease progression. These findings should aid in determining the optimal times for therapies that aim to treat or cure this disease. http://www.physorg.com/news159115703.html Medicine & Health Thu, 16 Apr 2009 15:48:50 EST news159115703 In a paper published in the early online version of Nature Structural and Molecular Biology, researchers at the University of Pittsburgh School of Medicine deconstruct the first steps in an intricate molecular dance that might lead to the formation of pathogenic protein clumps in Huntington's disease, and possibly other movement-related neurological disorders. http://www.physorg.com/news155749490.html Biology Sun, 08 Mar 2009 16:45:59 EST news155749490 Recent animal studies have shown that clioquinol - an 80-year old drug once used to treat diarrhea and other gastrointestinal disorders - can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases. Scientists, however, had a variety of theories to attempt to explain how a single compound could have such similar effects on three unrelated neurodegenerative disorders. http://www.physorg.com/news150483871.html Chemistry Tue, 06 Jan 2009 17:04:31 EST news150483871