http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Lung cancer is the leading cause of cancer mortality worldwide and lung adenocarcinoma is the most common type. Many cases of lung adenocarcinoma are attributed to a mutation in a gene for the epidermal growth factor receptor (EGFR). Lung cancer with changes in EGFR is initially treatable with a family of chemotherapeutic agents called tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. However, patients often develop resistance to these drugs through the acquisition of additional changes or secondary mutations that allow cancer cells to evade treatment. http://www.physorg.com/news179559120.html Medicine & Health Wed, 09 Dec 2009 05:33:55 EST news179559120 Two medications approved as treatment for drug-resistant chronic myeloid leukemia continue to provide patients with quicker, better responses as a first treatment than the existing front-line drug, researchers at The University of Texas M. D. Anderson Cancer Center reported at the 51st Annual Meeting of the American Society of Hematology. http://www.physorg.com/news179415337.html Medicine & Health Mon, 07 Dec 2009 13:37:14 EST news179415337 Results from a phase II clinical trial indicate a novel drug may provide a treatment option for chronic myeloid leukemia (CML) patients who do not respond to current therapies, researchers from The University of Texas M. D. Anderson Cancer Center report today at the 51st Annual Meeting of the American Society of Hematology. http://www.physorg.com/news179401627.html Medicine & Health Mon, 07 Dec 2009 10:00:01 EST news179401627 Publishing in PLoS Pathogens, researchers at from the Kimmel Cancer Center at Jefferson have found a novel mechanism by which drugs block HIV-1 from entering host cells. http://www.physorg.com/news178809016.html Medicine & Health Mon, 30 Nov 2009 13:11:08 EST news178809016 (PhysOrg.com) -- Researchers at the University of Cincinnati have documented that the brain hormone serotonin is made in human breast cancer cells and functions abnormally, contributing to malignant growth. http://www.physorg.com/news178308579.html Medicine & Health Tue, 24 Nov 2009 18:20:02 EST news178308579 Despite being highly effective and beneficial for many patients, unexpected consequences are emerging in patients who are prescribed proton pump inhibitors (PPIs) for reflux diseases. Physicians are warned to monitor these effects and prescribe these medications carefully, according to a new commentary published in the November 2009 issue of Otolaryngology - Head and Neck Surgery. http://www.physorg.com/news176403707.html Medicine & Health Tue, 03 Nov 2009 01:10:02 EST news176403707 (PhysOrg.com) -- Researchers in Denmark have studied almost half a million Danish children and found a slightly higher rate of septal heart abnormalities in babies whose mothers took an SSRI antidepressant drug during early pregnancy, especially if they took more than one type. http://www.physorg.com/news173424171.html Medicine & Health Tue, 29 Sep 2009 07:10:02 EST news173424171 Aromatase inhibitors, the same drugs that have buoyed long-term survival rates among breast cancer patients, also carry side effects including joint pain so severe that many patients discontinue these lifesaving medicines. New University of Pennsylvania School of Medicine research, however, has uncovered patterns that may help clinicians identify and help women at risk of these symptoms sooner in order to increase their chances of sticking with their treatment regimen. http://www.physorg.com/news173356992.html Medicine & Health Mon, 28 Sep 2009 11:43:54 EST news173356992 New research has found that switching post-menopausal women with early breast cancer to the drug exemestane (Aromasin) after two or three years of tamoxifen rather than keeping them on tamoxifen for five years improves the chance of remaining cancer free and reduces the risk of death for at least the next six years. http://www.physorg.com/news172779638.html Medicine & Health Mon, 21 Sep 2009 20:00:01 EST news172779638 (PhysOrg.com) -- Virginia Commonwealth University School of Medicine researchers have discovered a new role for the bioactive lipid messenger, sphingosine-1-phosphate, or S1P, that is abundant in our blood - a finding that could lead to a new generation of drugs to fight cancer and inflammatory disease. http://www.physorg.com/news171644446.html Medicine & Health Tue, 08 Sep 2009 16:01:32 EST news171644446 UCSF researchers have successfully used protease inhibitors to restore to normal levels a key protein involved in early brain development. Reduced levels of that protein have been shown to cause the rare brain disorder lissencephaly, which is characterized by brain malformations, seizures, severe mental retardation and very early death in human infants. http://www.physorg.com/news171459656.html Medicine & Health Sun, 06 Sep 2009 12:41:58 EST news171459656 A mutation in a gene that helps regulate high blood pressure is a cause of inherited kidney disease, according to a new study by researchers at Wake Forest University School of Medicine, Charles University in Prague and colleagues. http://www.physorg.com/news169827634.html Medicine & Health Tue, 18 Aug 2009 15:30:01 EST news169827634 A particular class of medication used to treat high blood pressure could protect older adults against memory decline and other impairments in cognitive function, according to a newly published study from Wake Forest University School of Medicine. http://www.physorg.com/news167548521.html Medicine & Health Thu, 23 Jul 2009 06:50:01 EST news167548521 Treatment with proton pump inhibitors (PPIs) for eight weeks induces acid-related symptoms like heartburn, acid regurgitation and dyspepsia once treatment is withdrawn in healthy individuals, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. http://www.physorg.com/news165646737.html Medicine & Health Wed, 01 Jul 2009 06:10:02 EST news165646737 Prostasin, a relatively unknown protease enzyme expressed in most epithelial cells, may play a role in the genesis of colorectal cancer. Researchers writing in the open access journal BMC Cancer have associated a reduction in the expression of inhibitors of the enzyme with malignant cellular behavior. http://www.physorg.com/news165125421.html Medicine & Health Thu, 25 Jun 2009 05:11:02 EST news165125421 Latent HIV genes can be 'smoked out' of human cells. The so-called 'shock and kill' technique, described in a preclinical study in BioMed Central's open access journal Retrovirology, might represent a new milestone along the way to the discovery of a cure for HIV/AIDS. http://www.physorg.com/news163328174.html Medicine & Health Thu, 04 Jun 2009 09:58:56 EST news163328174 The antidepressant citalopram does not appear to reduce the occurrence of repetitive behaviors in children and teens with autism spectrum disorders, according to a report in the June issue of Archives of General Psychiatry. http://www.physorg.com/news163093138.html Medicine & Health Mon, 01 Jun 2009 16:39:21 EST news163093138 A recent study finds that the antidepressant effects of drugs like Prozac involve both neurogenesis-dependent and -independent mechanisms, a finding that may lead to development of better treatments for depression and anxiety. The research, published by Cell Press in the May 28th issue of the journal Neuron, utilizes a new experimental mouse model of depression/anxiety that is the first to permit simultaneous examination of multiple effects of antidepressant treatment in the same animal. http://www.physorg.com/news162647379.html Medicine & Health Wed, 27 May 2009 12:52:33 EST news162647379 Researchers at the University of California, San Diego have discovered that a complex network of interactions between drugs and the proteins with which they bind can explain adverse drug effects. Their findings suggest that adverse drug effects might be minimized by using single or multiple drug therapies in order to fine-tune multiple off-target interactions. http://www.physorg.com/news161609790.html Medicine & Health Fri, 15 May 2009 12:37:16 EST news161609790 The anti-clotting action of the medication clopidogrel (Plavix) can be compromised by common drugs for the treatment of heartburn and ulcers resulting in a roughly 50% increase in the combined risk of hospitalization for heart attack, stroke and other serious cardiovascular illnesses, according to a new study presented today at the Society for Cardiovascular Angiography and Interventions (SCAI) 32nd Annual Scientific Sessions. The study specifically focused on the effects of proton pump inhibitors (PPI) omeprazole (Prilosec), esomeprazole (Nexium), pantoprazole (Protonix), and lansoprazole (Prevacid), which together accounted for about 96% of PPI use in the study. http://www.physorg.com/news160836316.html Medicine & Health Wed, 06 May 2009 13:45:38 EST news160836316 (PhysOrg.com) -- A team led by researchers at MIT's Picower Institute for Learning and Memory has now pinpointed the exact gene responsible for a 2007 breakthrough in which mice with symptoms of Alzheimer's disease regained long-term memories and the ability to learn. http://www.physorg.com/news160835025.html Medicine & Health Wed, 06 May 2009 13:24:31 EST news160835025 Scientists may need to rethink the design of drugs meant to block HIV from infecting human cells, according to a study that appears in the May 1st issue of the journal Cell, a Cell Press publication. That's because the new report shows that HIV doesn't enter cells in the way that experts had generally assumed it did. http://www.physorg.com/news160316570.html Medicine & Health Thu, 30 Apr 2009 13:23:27 EST news160316570 An experimental agent has shown promising results in people with advanced biliary cancer, according to a multi-institutional clinical trial led by cancer researchers at the Ohio State University. http://www.physorg.com/news159461766.html Medicine & Health Mon, 20 Apr 2009 15:56:30 EST news159461766 Researchers at the University of Southern California have identified a new drug compound that appears to target tumor cells and surrounding blood vessels without the negative side effects typically associated with Cox-2 inhibitors. http://www.physorg.com/news159439792.html Medicine & Health Mon, 20 Apr 2009 09:50:24 EST news159439792 Two medications used to treat erectile dysfunction in men (tadalafil and sildenafil) do not appear to have visual side effects when taken daily for six months, despite concerns about eye-related complications, according to a report in the April issue of Archives of Ophthalmology. http://www.physorg.com/news158862890.html Medicine & Health Mon, 13 Apr 2009 17:36:52 EST news158862890 With the Jewish holiday of Passover beginning at sundown next Wednesday, April 8, a staple of the traditional dinner -- chicken soup with matzoh balls -- may take on medicinal importance based on findings published in the American Chemical Society's Journal of Agricultural and Food Chemistry. http://www.physorg.com/news157894915.html Chemistry Thu, 02 Apr 2009 12:42:27 EST news157894915 A chemical component of licorice may offer a new approach to preventing colorectal cancer without the adverse side effects of other preventive therapies, Vanderbilt University Medical Center researchers report. http://www.physorg.com/news157047274.html Medicine & Health Mon, 23 Mar 2009 17:16:48 EST news157047274 (PhysOrg.com) -- A new drug developed at the University of California, Davis, to treat diabetes, hypertension and inflammatory diseases has entered Phase IIa of human clinical trials to evaluate its efficacy. http://www.physorg.com/news155494845.html Medicine & Health Thu, 05 Mar 2009 17:02:18 EST news155494845 Current arthritis medications can ease the pain, but stopping the progression of the disease requires more aggressive treatments: use of very limited available drugs or surgical intervention. University of Missouri researchers hope to find new therapeutic targets for arthritis by studying the interaction between two proteins that, if interrupted, may prevent arthritis pain caused by joint damage. In a new study, researchers have found potential evidence that blocking the proteins responsible for inducing inflammation prevents cartilage breakdown. http://www.physorg.com/news154200560.html Chemistry Wed, 18 Feb 2009 17:33:01 EST news154200560 Selective serotonin reuptake inhibitors (SSRIs) may reduce the risk of suicide in depressed adults, according to a study by researchers from the World Health Organization and the University of Verona, Italy published in CMAJ http://www.cmaj.ca/press/pg291.pdf. http://www.physorg.com/news152817013.html Medicine & Health Mon, 02 Feb 2009 17:10:33 EST news152817013