http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. The spread, or metastasis, of individual breast cancer cells from the main tumor into the blood circulation to the lungs and other body tissues and organs is under the control of a growth factor abbreviated TGFb, according to a study with laboratory mice that will be presented at the American Society for Cell Biology 49th Annual Meeting, Dec. 5-9, 2009 in San Diego. http://www.physorg.com/news179328871.html Medicine & Health Sun, 06 Dec 2009 13:50:01 EST news179328871 (PhysOrg.com) -- UCSF scientists have shown for the first time that the rigidity of a tissue can induce cancer. The research team identified an enzyme that is crucial for regulating tissue stiffness and demonstrated that the enzyme can turn abnormal but non-malignant breast tissue into tumors, according to a study published in Cell online. http://www.physorg.com/news178221935.html Medicine & Health Mon, 23 Nov 2009 18:40:01 EST news178221935 Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor. http://www.physorg.com/news177771822.html Chemistry Wed, 18 Nov 2009 13:04:21 EST news177771822 Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer. In a study in mice, the team of researchers from Tufts University School of Medicine, the Sackler School of Graduate Biomedical Sciences at Tufts, and Tufts Medical Center report that inhibiting ROCK, or Rho-associated kinase, in the earliest stages of breast cancer decreased metastatic tumor mass in bone by 77 percent and overall frequency of metastasis by 36 percent. The results suggest that ROCK may be a target for new drug therapies to reduce breast cancer metastasis. http://www.physorg.com/news176478108.html Medicine & Health Tue, 03 Nov 2009 13:42:26 EST news176478108 Metastases are responsible for over 90% of cancer deaths. In the upcoming issue of G&D, Dr. Robert Weinberg (MIT) and colleagues lend molecular insight into how microRNAs suppress tumor metastasis. http://www.physorg.com/news175972344.html Medicine & Health Wed, 28 Oct 2009 18:40:03 EST news175972344 A clinical research team from Taiwan reported a case of asymptomatic pancreatic divisum who underwent palliative subtotal gastrectomy for an advanced gastric cancer with liver metastasis. They concluded for patients with pancreas divisum or dominant duct of Santorini who fail to follow the normal post-operative course after gastrectomy, clinicians should be alert to the possibility of post-gastrectomy acute pancreatitis as one of the potential diagnoses. http://www.physorg.com/news174915265.html Medicine & Health Fri, 16 Oct 2009 14:40:03 EST news174915265 Researchers at the National Cancer Center in Japan have developed a system for detecting 70 percent of postoperative stomach cancer relapses, according to sources. http://www.physorg.com/news173970234.html Medicine & Health Mon, 05 Oct 2009 14:20:02 EST news173970234 Researchers at The Wistar Institute have identified a key gene (KLF17) involved in the spread of breast cancer throughout the body. They also demonstrated that expression of KLF17 together with another gene (Id1) known to regulate breast cancer metastasis accurately predicts whether the disease will spread to the lymph nodes. Previously, the function of KLF17 had been unknown. http://www.physorg.com/news173969331.html Medicine & Health Mon, 05 Oct 2009 13:49:16 EST news173969331 The Stowers Institute's Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical role in the process of mitosis. The work, conducted in yeast cells, was published in the most recent issue of Molecular Cell. http://www.physorg.com/news173366310.html Biology Mon, 28 Sep 2009 14:19:39 EST news173366310 Berlin, Germany: Researchers have shown for the first time that patterns of ultrasound signals can be used to identify whether or not cancer has started to spread in melanoma patients, and to what extent. The discovery enables doctors to decide on how much surgery, if any, is required and to predict the patient's probable survival. http://www.physorg.com/news172908892.html Medicine & Health Wed, 23 Sep 2009 08:20:03 EST news172908892 Researchers at the National Cancer Institute have identified a gene that may play a role in breast cancer metastasis to the brain, according to a report in Molecular Cancer Research, a journal of the American Association for Cancer Research. http://www.physorg.com/news171031223.html Medicine & Health Tue, 01 Sep 2009 13:41:22 EST news171031223 One of the biggest challenges in scientists' quest to develop new and better treatments for cancer is gaining a better understanding of how and why cancer spreads. Recent breakthroughs have uncovered how different cellular proteins are turned 'on' or 'off' at the molecular level, but much remains to be understood about how protein signaling influences cell behavior. http://www.physorg.com/news169906799.html Chemistry Wed, 19 Aug 2009 13:20:31 EST news169906799 Dr. Glen Weiss of the Translational Genomics Research Institute (TGen) and Scottsdale Healthcare this week announced two significant advances in treating lung cancer at an international cancer research conference. http://www.physorg.com/news168873562.html Medicine & Health Fri, 07 Aug 2009 14:19:53 EST news168873562 (PhysOrg.com) -- The masterpieces that spring from the talents of Rembrandt, Van Gogh and other artists often begin with the creation of a gradient of colors on a palette. In a similar manner, researchers at the National Institute of Standards and Technology have created an innovative device called the `microfluidic palette` to produce multiple, steady-state chemical gradients -gradual changes in concentration across an area -in a miniature chamber about the diameter of a pinhead. The tool can be used to study the complex biological mechanisms in cells responsible for cancer metastasis, wound healing, biofilm formation and other fluid-related processes. http://www.physorg.com/news168018490.html Chemistry Tue, 28 Jul 2009 17:50:03 EST news168018490 Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade surrounding tissues. The study was published in the journal Cancer Research on June 15. http://www.physorg.com/news167659729.html Medicine & Health Fri, 24 Jul 2009 13:40:01 EST news167659729 (PhysOrg.com) -- In new research on prostate cancer to bone metastasis, Dr. Phillip Trackman of Boston University Henry M. Goldman School of Dental Medicine explains that the lysyl oxidase pro-peptide (LOX-PP) inhibits prostate cancer cell growth in vitro by inhibiting the activity of a key growth factor known as Fibroblast Growth Factor 2, or FGF-2. http://www.physorg.com/news166289142.html Medicine & Health Mon, 13 Jul 2009 05:00:01 EST news166289142 Researchers from Boston University School of Medicine (BUSM) have shown that endoscopic surgery is a valid treatment option for treating esthesioneuroblastoma (cancer of the nasal cavity), in addition to traditional open surgery and nonsurgical treatments. These findings appear in the July issue of Laryngoscope. http://www.physorg.com/news166193023.html Medicine & Health Tue, 07 Jul 2009 14:20:01 EST news166193023 A new prostate cancer risk assessment test, developed by a UCSF team, gives patients and their doctors a better way of gauging long-term risks and pinpointing high risk cases. http://www.physorg.com/news164279202.html Medicine & Health Mon, 15 Jun 2009 10:07:19 EST news164279202 High levels of a tiny fragment of RNA appear to suppress the spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research. http://www.physorg.com/news164079755.html Medicine & Health Sat, 13 Jun 2009 04:50:01 EST news164079755 As survival rates among some patients with cancer continue to rise, so does the spread of these cancers to the brain - as much as 40 percent of all diagnosed brain cancers are considered metastatic, having spread from a primary cancer elsewhere in the body. http://www.physorg.com/news163700779.html Medicine & Health Mon, 08 Jun 2009 17:26:57 EST news163700779 (PhysOrg.com) -- A study led by specialists at the Brain Tumor Center at the University of Cincinnati (UC) Neuroscience Institute affirms the benefits and safety of aggressive, localized treatment for patients with a single brain metastasis. http://www.physorg.com/news163693515.html Medicine & Health Mon, 08 Jun 2009 15:26:21 EST news163693515 You know the guy -- he's your Facebook friend. The one who knows everyone. Secure at the center of a dense web of relationships, he suggests causes and reconnects old friends like a skilled matchmaker. Scientists have known for some time that biological molecules interact with one another in a similarly complex pattern. Now researchers at the Stanford University School of Medicine have determined that hamstringing these molecular powerbrokers is a good way to derail processes such as cancer development. http://www.physorg.com/news163078173.html Medicine & Health Mon, 01 Jun 2009 12:30:11 EST news163078173 Novel chemotherapy and biological agents for metastatic colorectal cancer, combined with surgical advances in liver resection, have resulted in a dramatic increase in survival for patients with advanced disease, according to researchers at The University of Texas M. D. Anderson Cancer Center. http://www.physorg.com/news162579680.html Medicine & Health Tue, 26 May 2009 18:01:47 EST news162579680 Research led by David Worthylake, PhD, Assistant Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans, may help lay the groundwork for the development of a compound to prevent the spread of cancer. The research will be published in the May 29, 2009 issue of the Journal of Biological Chemistry. http://www.physorg.com/news162132055.html Chemistry Thu, 21 May 2009 13:41:33 EST news162132055 A new phase III clinical trial of early stage breast cancer patients has shown that a molecule designed to home in on nearby lymph nodes is just as accurate as current techniques, but faster, more specific and easier to use. http://www.physorg.com/news160994755.html Medicine & Health Fri, 08 May 2009 09:47:03 EST news160994755 New research led by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC) identifies three genes that specifically mediate the metastasis, or spread, of breast cancer to the brain and illuminates the mechanisms by which this spread occurs. The study was published online today in Nature. http://www.physorg.com/news160835111.html Medicine & Health Wed, 06 May 2009 13:26:09 EST news160835111 (PhysOrg.com) -- In a finding that could change the way breast cancer is treated, researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have identified a new marker for breast cancer metastasis. http://www.physorg.com/news159121757.html Medicine & Health Thu, 16 Apr 2009 17:29:58 EST news159121757 Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer that spreads elsewhere in the body, known as metastasis, is the process that most often leads to death from the disease. http://www.physorg.com/news157559721.html Biology Sun, 29 Mar 2009 15:36:30 EST news157559721 Researchers at the University of Virginia Health System have found that one of the genes commonly thought to promote the growth and spread of some types of cancers is in fact beneficial in bladder cancer - a major discovery that could significantly alter the way bladder cancers are treated in the future. http://www.physorg.com/news157210523.html Medicine & Health Wed, 25 Mar 2009 14:35:52 EST news157210523 The invasion or metastasis of pancreatic cancer has been known to be a complex process involving many molecular mechanisms, of which proteolytic degradation of extracellular matrix (ECM) exerted by matrix metalloproteinases (MMPs) was considered to be an essential step. Some data suggest that MMP-2 is involved in pancreatic cancer invasion and metastasis, and a high level of MMP-2 has been found to correlate with poor prognosis in patients with pancreatic cancer. Therefore, inhibition of MMP-2 may be of great value in both preventing pancreatic cancer and blocking metastasis of established tumors. http://www.physorg.com/news155817629.html Medicine & Health Mon, 09 Mar 2009 11:41:34 EST news155817629