http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. To identify the hemophilia mutation that affected Queen Victoria and her European relatives, scientific detectives used a cutting-edge "deep sequencing tool." Able to trace rare genetic disease mutations, the tool can turn a single laboratory into a fertile genetic research center. http://www.physorg.com/news180705775.html Medicine & Health Tue, 22 Dec 2009 12:20:06 EST news180705775 (PhysOrg.com) -- Researchers at the University of Toronto and Goethe University in Germany have discovered a protein that can inhibit the growth of cancer cells, providing crucial clues for the future development of new drugs to treat the disease. http://www.physorg.com/news180624608.html Medicine & Health Mon, 21 Dec 2009 13:36:48 EST news180624608 Walter and Eliza Hall Institute scientists have identified a key step in the biological process of programmed cell death, also called apoptosis. http://www.physorg.com/news180350680.html Medicine & Health Fri, 18 Dec 2009 09:45:53 EST news180350680 Tissue-specific genes, thought to be dormant or not marked for activation in embryonic stem cells, are indeed marked by transcription factors, with proper marking potentially crucial for the function of tissues derived from stem cells. http://www.physorg.com/news180181077.html Biology Wed, 16 Dec 2009 10:19:05 EST news180181077 Humans have the same receptors for detecting odors related to sex as do other apes and primates. But each species uses them in different ways, stemming from the way the genes for these receptors have evolved over time, according to Duke University researchers. http://www.physorg.com/news179507288.html Biology Tue, 08 Dec 2009 15:40:13 EST news179507288 Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis. Scientists hope the finding could lead to an effective therapy to target and inhibit the expression of this gene resulting in inhibition of cancer growth. http://www.physorg.com/news177945339.html Medicine & Health Fri, 20 Nov 2009 13:16:30 EST news177945339 (PhysOrg.com) -- Professor Robert Weiss has found that when two particular genes are inhibited, cancer cells are destroyed at a greater rate. The study is published in the Nov. 9 issue of PNAS. http://www.physorg.com/news177151857.html Medicine & Health Wed, 11 Nov 2009 09:00:01 EST news177151857 (PhysOrg.com) -- Diabetes is the most prevalent metabolic disease in developed countries and one that engenders - in addition to its high fatality - enormous health care costs. The physiological meaning of the ‘feel-good` hormone serotonin in insulin-producing cells of the pancreas was not understood for more than 40 years but has finally been resolved by scientists of the Max Planck Institute of Molecular Genetics in Berlin. The researchers Diego J. Walther, Nils Paulmann and colleagues report in the current issue of PloS Biology, that a lack of serotonin in the pancreas causes diabetes. http://www.physorg.com/news175962061.html Chemistry Wed, 28 Oct 2009 15:25:21 EST news175962061 While studying an HIV protein that plays an essential role in AIDS progression, researchers at the University of Pittsburgh School of Medicine have discovered compounds that show promise as novel treatments for the disease. http://www.physorg.com/news174664492.html Chemistry Tue, 13 Oct 2009 15:10:03 EST news174664492 Scientists at The Medical College of Wisconsin in Milwaukee have successfully produced liver cells from patients' skin cells opening the possibility of treating a wide range of diseases that affect liver function. The study was led by Stephen A. Duncan, D. Phil., Marcus Professor in Human and Molecular Genetics, and professor of cell biology, neurobiology and anatomy, along with postdoctoral fellow Karim Si-Tayeb, Ph.D., and graduate student Ms. Fallon Noto. http://www.physorg.com/news174245427.html Medicine & Health Thu, 08 Oct 2009 19:30:01 EST news174245427 The action of a small protein that is a major villain in Alzheimer's disease can be counterbalanced with another brain protein, researchers at UT Southwestern Medical Center have found in an animal study. http://www.physorg.com/news174050789.html Medicine & Health Tue, 06 Oct 2009 12:27:06 EST news174050789 (PhysOrg.com) -- Cancer predisposition resulting from the presence of a specific gene variant shows a strong gender bias, researchers at the University of Cincinnati (UC) have demonstrated. http://www.physorg.com/news172770958.html Medicine & Health Mon, 21 Sep 2009 16:56:19 EST news172770958 (PhysOrg.com) -- Researchers from the University of Washington and the University of Florida used gene therapy to cure two squirrel monkeys of color blindness - the most common genetic disorder in people. http://www.physorg.com/news172325926.html Medicine & Health Wed, 16 Sep 2009 13:19:09 EST news172325926 (PhysOrg.com) -- Scientists from University of Toronto and the Samuel Lunenfeld Research Institute of Mount Sinai Hospital have discovered a molecular link between intelligence and curiosity, which may lead to the development of drugs to improve learning. http://www.physorg.com/news172174436.html Medicine & Health Mon, 14 Sep 2009 19:14:27 EST news172174436 Scientists at the Gladstone Institute of Cardiovascular Disease have traced the evolution of the four-chambered human heart to a common genetic factor linked to the development of hearts in turtles and other reptiles. http://www.physorg.com/news171116708.html Medicine & Health Wed, 02 Sep 2009 14:00:17 EST news171116708 Genetic researchers at Children's Memorial Hospital, Chicago, are aggressively identifying adult patients who suffer from the genetic disorder, Phenylketonuria (PKU), and are presenting those findings at the 11th International Congress of Inborn Errors of Metabolism in San Diego, August 29 through September 2. http://www.physorg.com/news170498810.html Medicine & Health Wed, 26 Aug 2009 10:00:01 EST news170498810 A study from the Center for Molecular Genetics at the University of California, San Diego School of Medicine shows that a gene called HPRT plays an important role in setting the program by which primitive or precursor cells decide to become normal nerve cells in the human brain. This unconventional view of metabolic genes known as "housekeeping" genes is now online at the journal Molecular Therapy. http://www.physorg.com/news169985095.html Medicine & Health Thu, 20 Aug 2009 11:20:03 EST news169985095 University of Illinois at Chicago College of Medicine researchers have discovered how some recently approved drugs act against cancer cells. The finding may lead to a more effectively targeted anti-cancer strategy. http://www.physorg.com/news169282711.html Medicine & Health Wed, 12 Aug 2009 07:58:56 EST news169282711 University of Florida researchers have safely given new, functional genes to patients with a hereditary defect that can lead to fatal lung and liver diseases, according to clinical trial findings slated to appear this week in the online early edition of the Proceedings of the National Academy of Sciences. http://www.physorg.com/news169140806.html Medicine & Health Mon, 10 Aug 2009 17:10:03 EST news169140806 (PhysOrg.com) -- The secret to fighting often lethal drug resistant fungal infections is to knock out the bug's molecular chaperone, according to U of T researchers. http://www.physorg.com/news168263294.html Biology Fri, 31 Jul 2009 12:49:04 EST news168263294 (PhysOrg.com) -- Research at the University of Cincinnati has led to the first published structure of myostatin, a protein that regulates muscle growth in animals, offering hope for major advances in the fight against muscle-wasting diseases. http://www.physorg.com/news168192923.html Biology Thu, 30 Jul 2009 18:40:02 EST news168192923 Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., Sigma-Aldrich Corporation, Open Monoclonal Technology, Inc. (OMT) and INSERM today announced the creation of the first genetically modified mammals developed using zinc finger nuclease (ZFN) technology. http://www.physorg.com/news167579299.html Biology Thu, 23 Jul 2009 15:40:05 EST news167579299 Schizophrenia is a severely debilitating psychiatric disease that is thought to have its roots in the development of the nervous system; however, major breakthroughs linking its genetics to diagnosis, prognosis and treatment are still unrealized. Jill Morris, PhD assistant professor of Pediatrics at Northwestern University's Feinberg School of Medicine and a researcher in the Human Molecular Genetics Program of Children's Memorial Research Center studies a gene that is involved in susceptibility to schizophrenia, Disc1 (Disrupted-In-Schizophrenia 1). http://www.physorg.com/news167398118.html Medicine & Health Tue, 21 Jul 2009 12:29:09 EST news167398118 Virginia Commonwealth University researchers have identified a gene that may play a key role in regulating tumor progression in neuroblastoma, a form of cancer usually found in young children. Scientists hope the finding could lead to an effective therapy to inhibit the expression of this gene. http://www.physorg.com/news163089207.html Medicine & Health Mon, 01 Jun 2009 15:33:47 EST news163089207 An emerging form of the pathogenic yeast Candida is able to complete a full sexual cycle in a test tube, even though it's missing the genes for reproduction. And it may also do so while infecting us, according to Duke University Medical Center researchers. http://www.physorg.com/news162395184.html Biology Sun, 24 May 2009 14:47:12 EST news162395184 A new study uncovers a molecular mechanism that explains why joints fail to develop in embryos with paralyzed limbs. The research, published by Cell Press in the May issue of the journal Developmental Cell, answers a longstanding question about the influence of muscle activity on developing joints and underscores the critical contribution of movement to regulation of a signaling pathway that is important during development and beyond. http://www.physorg.com/news161869493.html Medicine & Health Mon, 18 May 2009 12:46:11 EST news161869493 Researchers from the Peninsula Medical School and the University of Bristol, using data from the Avon Longitudinal Study of Parents and Children and the Exeter Family Study of Childhood Health, have identified a common genetic variant that explains why some women may find it more difficult to quit smoking during pregnancy. http://www.physorg.com/news161604372.html Medicine & Health Fri, 15 May 2009 11:06:47 EST news161604372 Why is the immune system able to fight off some viruses but not others, leading to chronic, life-threatening infections like HIV and hepatitis C? http://www.physorg.com/news160995119.html Biology Fri, 08 May 2009 09:52:30 EST news160995119 By painstakingly silencing genes one at a time, scientists at Duke University Medical Center have identified dozens of proteins the dengue fever virus depends upon to grow and spread among mosquitoes and humans. http://www.physorg.com/news159626121.html Medicine & Health Wed, 22 Apr 2009 13:35:46 EST news159626121 Medical College of Wisconsin Cancer Center researchers in Milwaukee have learned that a protein, CXCL12, that normally controls intestinal cell movement, has the potential to halt colorectal cancer spreading. These studies represent a potential mechanism by which CXL12 may slow cancer spreading. Controlling this process could lead to new biological therapies for colorectal cancers. http://www.physorg.com/news159542551.html Medicine & Health Tue, 21 Apr 2009 14:23:03 EST news159542551