http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Case Western Reserve University School of Medicine assistant professor in the Center for RNA Molecular Biology, Jeff Coller, Ph.D., and his team discovered that messenger RNA (mRNA) predominately degrade on ribosomes, fundamentally altering a common understanding of how gene expression is controlled within the cell. The study, "Co-translational mRNA decay in Saccharomyces cerevisiae", is published in the latest issue of Nature. http://www.physorg.com/news170256361.html Biology Sun, 23 Aug 2009 14:26:29 EST news170256361 The tail ends of cellular protein templates, regions often thought relatively inconsequential, may actually play a role in preventing normal cells from becoming cancerous. http://www.physorg.com/news169993402.html Medicine & Health Thu, 20 Aug 2009 13:24:01 EST news169993402 Thousands of scientists and hundreds of software programmers studying the process by which RNA inside cells normally degrades may soon broaden their focus significantly. http://www.physorg.com/news168179768.html Biology Thu, 30 Jul 2009 13:41:02 EST news168179768 Prostasin, a relatively unknown protease enzyme expressed in most epithelial cells, may play a role in the genesis of colorectal cancer. Researchers writing in the open access journal BMC Cancer have associated a reduction in the expression of inhibitors of the enzyme with malignant cellular behavior. http://www.physorg.com/news165125421.html Medicine & Health Thu, 25 Jun 2009 05:11:02 EST news165125421 The colorectal cancer is thought to be resulted from a combination of environmental factors, diet, lifestyle, chronic inflammation and accumulation of specific genetic alterations. The pathogenesis and development of colorectal cancer involve multi-genes and multi-steps. TSPAN1 (GenBank Accession No. AF065388) is a new member of TM4SF located at chromosome 1 p34.1. It encodes a 241 amino acid protein. TSPAN1 was reported as a tumor-related gene recently. http://www.physorg.com/news162213544.html Medicine & Health Fri, 22 May 2009 12:19:27 EST news162213544 (PhysOrg.com) -- Scientists at Oxford University have tamed a virus so that it attacks and destroys cancer cells but does not harm healthy cells. The research funded by Cancer Research UK is published in the journal PLoS Pathogens. http://www.physorg.com/news162182584.html Medicine & Health Fri, 22 May 2009 03:43:59 EST news162182584 Researchers have determined the structure of a key genetic mechanism at work in bacteria, including some that are deadly to humans, in an important step toward the design of a new class of antibiotics, according to an accelerated publication that appeared online today as a "paper of the week" in the Journal of Biological Chemistry. http://www.physorg.com/news159188021.html Chemistry Fri, 17 Apr 2009 11:56:18 EST news159188021 Migration of colonic lamina propria fibroblasts (CLPF) plays an important role during the progression of fibrosis and fistulae in Crohn's disease. Transforming growth factor- beta (TGF- beta) is involved in the regulation of cell migration, cell differentiation, extracellular matrix deposition, and immune responses. Since the regulation of migration and differentiation of intestinal fibroblasts is an important mechanism during intestinal wound healing and fibrosis, it is important to investigate the effect of TGF- beta 1 on these processes and on fibronectin (FN) and FN isoform production. http://www.physorg.com/news157637926.html Medicine & Health Mon, 30 Mar 2009 13:19:20 EST news157637926 Scientists at the Georgia Institute of Technology have used a new approach, known as RNA-Seq, to profile the gene expression of the bacterium that causes anthrax, Bacillus anthracis. Their study, published March 20, 2009, online by the Journal of Bacteriology, marks the first time any bacterial transcriptome -the complete collection of mRNAs produced by a bacterium as it expresses different genes -has been comprehensively defined, and provides a much more detailed view of how bacteria regulate their gene expression. http://www.physorg.com/news156774964.html Biology Fri, 20 Mar 2009 13:36:29 EST news156774964 Most aphids host mutualistic bacteria, Buchnera aphidicola, which live inside specialized cells called bacteriocytes. Buchnera are vital to the aphids well being as they provide essential amino acids that are scarce in its diet. Now research published in the open access journal BMC Biology suggests that the aphids' ability to host Buchnera depends on genes they acquired from yet another species of bacteria via lateral gene transfer (LGT). http://www.physorg.com/news155845431.html Biology Mon, 09 Mar 2009 19:25:01 EST news155845431 Researchers from Boston University School of Medicine (BUSM) have demonstrated that a recently discovered class of molecule called microRNA (miRNAs), regulate the gene expression changes in airway cells that occur with smoking and lung cancer. These findings, which appear in the on-line early edition of journal Proceedings of the National Academy of Sciences, may lead to a new, relatively non-invasive biomarker for smoking-related lung diseases. http://www.physorg.com/news151076573.html Biology Tue, 13 Jan 2009 13:42:53 EST news151076573