http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Two signaling pathways essential to normal human development - the Wnt/Wingless (Wnt) and epidermal growth factor receptor (EGFR) pathways - interact in ways that can promote tumor cell invasion and metastasis, researchers from The University of Texas M. D. Anderson Cancer Center report in the Nov. 25 issue of Molecular Cell. http://www.physorg.com/news178377136.html Medicine & Health Wed, 25 Nov 2009 13:30:02 EST news178377136 Researchers at Iowa State University have found an essential key to possibly cure Parkinson's disease and are looking for others. http://www.physorg.com/news176464812.html Medicine & Health Tue, 03 Nov 2009 10:50:03 EST news176464812 (PhysOrg.com) -- Trichostatin A, an agent initially investigated in the laboratory as a possible cancer therapy, has been shown to inhibit contractions in muscle from the uterus and could have a role in preventing premature labour. http://www.physorg.com/news175518850.html Medicine & Health Fri, 23 Oct 2009 12:30:03 EST news175518850 (PhysOrg.com) -- Cancer cells fueled by the mutant KRAS oncogene, which makes them notoriously difficult to treat, can be killed by blocking a more vulnerable genetic partner of KRAS, report scientists at the Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT. http://www.physorg.com/news175272905.html Medicine & Health Tue, 20 Oct 2009 17:00:01 EST news175272905 A new study from the Montreal Neurological Institute and Hospital (The Neuro) of McGill University reveals that different patterns of training and learning lead to different types of memory formation. The significance of the study, published in the Journal of Neuroscience, is that it identifies the molecular differences between spaced training (distributed over time) and massed training (at very short intervals), shedding light on brain function and guiding learning and training principles. http://www.physorg.com/news173616029.html Medicine & Health Thu, 01 Oct 2009 12:00:01 EST news173616029 Recent studies conducted by Dr. Eric Blough and his colleagues at Marshall University have shown that use of the common pain reliever acetaminophen may help prevent age-associated muscle loss and other conditions. http://www.physorg.com/news172944205.html Medicine & Health Wed, 23 Sep 2009 17:06:19 EST news172944205 (PhysOrg.com) -- In its fight against an intruding virus, an enzyme in our immune system may sense certain types of viral RNA pairs, according to scientists. http://www.physorg.com/news168619740.html Biology Tue, 04 Aug 2009 16:40:01 EST news168619740 Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade surrounding tissues. The study was published in the journal Cancer Research on June 15. http://www.physorg.com/news167659729.html Medicine & Health Fri, 24 Jul 2009 13:40:01 EST news167659729 A Purdue University scientist has discovered a key process in cell growth that can lead to the formation of tumors. http://www.physorg.com/news166192963.html Chemistry Tue, 07 Jul 2009 14:00:02 EST news166192963 In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes spin out of control and become a brain tumor. http://www.physorg.com/news164892108.html Medicine & Health Mon, 22 Jun 2009 12:22:47 EST news164892108 Fox Chase Cancer Center investigators report that a two-drug blockade of mTOR signaling appears safe in metastatic kidney cancer in a phase I trial. Early data suggests that a combination of temsirolimus and bryostatin may be active in patients with rare forms of renal cell cancer, which are less likely to respond to other targeted therapies. http://www.physorg.com/news163000886.html Medicine & Health Sun, 31 May 2009 15:01:52 EST news163000886 Driving Miranda, a protein in fruit flies crucial to switch a stem cell's fate, is not as complex as biologists thought, according to University of Oregon biochemists. They've found that one enzyme (aPKC) stands alone and acts as a traffic cop that directs which roads daughter cells will take. http://www.physorg.com/news161519009.html Biology Thu, 14 May 2009 11:24:08 EST news161519009 Results of a study in mice by researchers at the University of California, San Diego strongly suggest that the protein kinase JNK1 plays a key role in the development of retinopathy in premature infants. Their findings, reported online the week of May 4-9 in advance of print in the Proceedings of the National Academy of Sciences (PNAS), may lead to an effective way to treat the leading cause of childhood blindness in industrialized countries using JNK1 inhibitors. http://www.physorg.com/news160676679.html Medicine & Health Mon, 04 May 2009 17:25:22 EST news160676679 An experimental agent has shown promising results in people with advanced biliary cancer, according to a multi-institutional clinical trial led by cancer researchers at the Ohio State University. http://www.physorg.com/news159461766.html Medicine & Health Mon, 20 Apr 2009 15:56:30 EST news159461766 Scientists have developed a new approach for surveying phosphorylation, a process that is regulated by critical cell signaling pathways and regulates several key cellular signaling events. The research, published by Cell Press in the April 10th issue of the journal Molecular Cell, describes the regulation of a previously uncharacterized protein and demonstrates that it plays an important role in cancer cell invasion. http://www.physorg.com/news158502443.html Medicine & Health Thu, 09 Apr 2009 13:27:55 EST news158502443 Based on research that reveals new insight into mechanisms that allow invasive tumor cells to move, researchers at the Mayo Clinic campus in Florida have a new understanding about how to stop cancer from spreading. A cancer that spreads elsewhere in the body, known as metastasis, is the process that most often leads to death from the disease. http://www.physorg.com/news157559721.html Biology Sun, 29 Mar 2009 15:36:30 EST news157559721 Scientists have determined that a specific gene plays a role in the weight-gain response to a high-fat diet. The finding in an animal study suggests that blocking this gene could one day be a therapeutic strategy to reduce diet-related obesity and associated disorders, such as diabetes and liver damage, in humans. http://www.physorg.com/news154712272.html Medicine & Health Tue, 24 Feb 2009 15:38:17 EST news154712272 You may never hear fruit flies snore, but rest assured that when you're asleep they are too. According to research published in the January 2009 issue of the journal Genetics, scientists from the University of Missouri-Kansas City have shown that the circadian rhythms (sleep/wake cycles) of fruit flies and vertebrates are regulated by some of the same "cellular machinery" as that of humans. This study is significant because the sleep-regulating enzyme analyzed in this research is one of only a few possible drug targets for circadian problems that can lead to seasonal affective disorder (SAD), insomnia, and possibly some cancers. http://www.physorg.com/news151064680.html Biology Tue, 13 Jan 2009 10:24:40 EST news151064680 Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer. http://www.physorg.com/news150389078.html Medicine & Health Mon, 05 Jan 2009 14:44:38 EST news150389078