http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals. In addition, the study provides supportive evidence for the use of inhibitors of ATR in cancer therapy. http://www.physorg.com/news174843234.html Medicine & Health Thu, 15 Oct 2009 17:20:01 EST news174843234 Researchers at The University of Texas M. D. Anderson Cancer Center have identified a protein that marks the tumor suppressor p53 for destruction, providing a potential new avenue for restoring p53 in cancer cells. http://www.physorg.com/news165254535.html Medicine & Health Fri, 26 Jun 2009 17:02:40 EST news165254535 University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more effective future treatments and a way to screen for the disease early. http://www.physorg.com/news163077804.html Medicine & Health Mon, 01 Jun 2009 12:24:13 EST news163077804 (PhysOrg.com) -- Protein p53 protects the body against cancer and is knocked out in many cancer tumours. Researchers at Karolinska Institutet have identified two molecules that can restore p53's cancer-killing properties. New results are now presented on the two substances, one of which will undergo clinical tests later this year. http://www.physorg.com/news161360881.html Medicine & Health Tue, 12 May 2009 15:28:56 EST news161360881 Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have demonstrated that naturally-occurring compounds can selectively deplete mutant p53 and restore "wild type" function to p53 in a variety of tumor cells. http://www.physorg.com/news159461636.html Medicine & Health Mon, 20 Apr 2009 15:54:40 EST news159461636 A new study sheds light on a little understood biological process called quiescence, which enables blood-forming stem cells to exist in a dormant or inactive state in which they are not growing or dividing. According to the study's findings, researchers identified the genetic pathway used to maintain a cell's quiescence, a state that allows bone marrow cells to escape the lethal effects of standard cancer treatments. http://www.physorg.com/news150726406.html Biology Fri, 09 Jan 2009 12:26:46 EST news150726406