http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- Bacteria use all sorts of cunning to trick hosts into doing their bidding. One con in their bag of tricks: the molecular mimic. In this ruse, bacteria or their agents look for all purposes like some native molecule in a cell, but then do not behave accordingly. Working with H. pylori, the bacterium responsible for gastric ulcers and cancer, researchers have revealed one way bacteria pull this off, deciphering the structure of a piece of CagA, a bacterial protein that impersonates a human protein in order to disable a key enzyme. http://www.physorg.com/news179759608.html Biology Fri, 11 Dec 2009 13:14:12 EST news179759608 The gastric cardiac adenocarcinoma (GCA) is a very rare disease. In recent decades, however, the incidence of the GCA has increased dramatically in many Western countries. An increasing trend in GCA is also observed in municipal regions but not in rural regions of China. Another striking feature is the strong male predominance among patients with GCA. Some of the reasons above are still unclear and require further epidemiological investigations. http://www.physorg.com/news178369840.html Medicine & Health Wed, 25 Nov 2009 11:40:04 EST news178369840 Helicobacter pylori has been accepted as an important pathogen inducing gastric cancer. A research group from Taiwan investigated optimal intervention point of Celecoxib, to inhibit H. pylori-associated gastric carcinogenesis in Mongolian gerbils. They found that short-term use resulted in less severe inflammation and inhibited the invasion degree of gastric cancer. Therefore, Celecoxib could be used in the later stages of H. pylori infection to achieve safe and effective chemoprevention of gastric adenocarcinoma. http://www.physorg.com/news175957992.html Medicine & Health Wed, 28 Oct 2009 19:20:02 EST news175957992 There is abundant evidence of an association between Helicobacter pylori chronic infection and gastric cancer. The incidence of gastric cancer is much higher in Japan than Indonesia. A research from Indonesia and Japan found there was a significant difference in the grade and activity of gastric mucosal changes between Indonesian and Japanese H. pylori positive patients. This finding may prove to be an initial step to explain the "Asian paradox." http://www.physorg.com/news175947009.html Medicine & Health Wed, 28 Oct 2009 11:24:23 EST news175947009 Helicobacter pylori (H pylori) is a gram negative bacterium which infects about 50% of the world population. H pylori colonization causes a strong systemic immune response. Various tools have been employed to identify the relationship between H pylori and gastric cancer, including c-DNA microarrays. However, most of these methods did not consider the systematic interaction of biological components. http://www.physorg.com/news174914486.html Medicine & Health Fri, 16 Oct 2009 13:00:01 EST news174914486 A special protein in the lining of the stomach has been shown to be an important part of the body's defense against the stomach ulcer bacterium Helicobacter pylori in a new study from the Sahlgrenska Academy at the University of Gothenburg. The discovery may explain why the bacterium makes some people more ill than others. http://www.physorg.com/news174661663.html Biology Tue, 13 Oct 2009 15:10:02 EST news174661663 Scientists are reporting discovery of a much sought after crack in the armor of a common microbe that infects the stomachs of one-sixth of the world's population, causing stomach ulcers and other diseases. They identified a group of substances that block a key chemical pathway that the bacteria need for survival. Their study, which could lead to new, more effective antibiotics to fight these hard-to-treat microbes, is scheduled for the October 16 issue of ACS Chemical Biology. http://www.physorg.com/news173529566.html Chemistry Wed, 30 Sep 2009 11:40:05 EST news173529566 Although it has been demonstrated that Helicobacter pylori causes gastric cancer, it is still controversial that whether H. pylori eradication therapy is effective in primary prevention of gastric cancer. This is especially important for Yamagata Prefecture, a region of Japan with the second highest incidence of gastric cancer in the world. http://www.physorg.com/news173099928.html Medicine & Health Fri, 25 Sep 2009 12:19:49 EST news173099928 Patients with upper gastrointestinal (GI) complaints visit their general practitioner (GP) more often than patients with other conditions. Researchers writing in the open access journal BMC Family Practice found that people with dyspepsia, heartburn, epigastric discomfort and other upper-abdominal complaints had almost twice as many GP contacts, which were ultimately associated with problems in all organ systems. These patients were twice as frequently referred to specialist care and received twice as many prescriptions. http://www.physorg.com/news171657841.html Medicine & Health Tue, 08 Sep 2009 20:20:02 EST news171657841 A team of researchers from Boston University, Harvard Medical School and Massachusetts Institute of Technology recently made a discovery that changes a long held paradigm about how bacteria move through soft gels. They showed that the bacterium that causes human stomach ulcers uses a clever biochemical strategy to alter the physical properties of its environment, allowing it to move and survive and further colonize its host. http://www.physorg.com/news169313255.html Chemistry Wed, 12 Aug 2009 17:00:05 EST news169313255 Helicobacter pylori bacteria, which can cause gastric ulcers, have been linked to type B insulin resistance syndrome in diabetics, researchers reported in the British medical journal The Lancet. http://www.physorg.com/news167403440.html Medicine & Health Tue, 21 Jul 2009 15:00:02 EST news167403440 Helicobacter pylori survives in the body by manipulating important immune system cells. This is shown in a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden. The discovery may lead to new treatments against the common peptic ulcer bacterium. http://www.physorg.com/news165494291.html Medicine & Health Mon, 29 Jun 2009 11:38:39 EST news165494291 The stomach ulcer bacterium Helicobacter pylori is not transmitted through drinking water as previously thought, but rather through vomit and possibly faeces. This is shown in a thesis at the Sahlgrenska Academy, University of Gothenburg, Sweden. It is therefore possible to prevent the spread of the bacterium in developing countries through some fairly simple measures. http://www.physorg.com/news165066763.html Medicine & Health Wed, 24 Jun 2009 12:53:35 EST news165066763 Current research suggests that levels of gastrin play a key role in the development of Helicobacter-induced stomach cancer. The related report by Takaishi et al, "Gastrin is an essential cofactor for Helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice," appears in the July 2009 issue of The American Journal of Pathology. http://www.physorg.com/news165045931.html Medicine & Health Wed, 24 Jun 2009 07:05:58 EST news165045931 Iron-deficiency anaemia (IDA) is commonly seen in women aged http://www.physorg.com/news164974749.html Medicine & Health Tue, 23 Jun 2009 11:19:30 EST news164974749 Nearly 20 years ago, it was discovered that bacteria known as Helicobacter pylori were responsible for stomach ulcers. Since then, antibiotics have become the primary therapy used to combat the H. pylori infection, which affects approximately six percent of the world population and is also a primary cause of stomach cancer. But today the bacteria is growing increasingly resistant to antibiotics. http://www.physorg.com/news161614249.html Medicine & Health Fri, 15 May 2009 13:51:13 EST news161614249 Heliobacter pylori (H. pylori) infection is considered one of the most important risk factors for stomach (or gastric) cancer with as much as 65% of all cases linked back to the bacteria, although exactly how this occurs is not fully clear. But now researchers in Denmark, Portugal and France, publishing in the journal Clinical Cancer Research, show that H. pylori infection contribution to cancer can be linked to at least three independent molecular pathways, which, when disturbed by infection, lead to mutations in the patients` gastric tissues. http://www.physorg.com/news160991589.html Medicine & Health Fri, 08 May 2009 08:54:22 EST news160991589 (PhysOrg.com) -- A small, pilot study in 50 people in Japan suggests that eating two and a half ounces of broccoli sprouts daily for two months may confer some protection against a rampant stomach bug that causes gastritis, ulcers and even stomach cancer. http://www.physorg.com/news158207312.html Medicine & Health Mon, 06 Apr 2009 03:29:15 EST news158207312 Results of the first human clinical studies confirm that a new yogurt fights the bacteria that cause gastritis and stomach ulcers with what researchers describe as almost vaccine-like effects, scientists in Japan will report today at the 237th National Meeting of the American Chemical Society. http://www.physorg.com/news156956005.html Medicine & Health Sun, 22 Mar 2009 15:54:01 EST news156956005 Resent studies reported that aspirin inhibited the growth of H. pylori in a dose-dependent manner and significantly affected the activity of virulence factors of H. pylori. In addition, aspirin increased the susceptibility of H. pylori to antimicrlbials including metronidazole, clarithromycin and amoxicillin. However, the mechanisms remained unknown. http://www.physorg.com/news155329433.html Medicine & Health Tue, 03 Mar 2009 19:08:20 EST news155329433 (PhysOrg.com) -- Helicobacter pylori can cause stomach ulcers and cancers. Over half of the world`s inhabitants carrys this bacterium, but different variants are present on different continents. Up to now, biologists have differentiated between five populations of these bacteria. Researchers at the Max Planck Institute for Infection Biology in Berlin and at the University of Cork in Ireland have now discovered a new population of Helicobacter pylori bacteria that attests to the shared origin of the earliest inhabitants of Australia and New Guinea. (Science, January 23rd, 2009) http://www.physorg.com/news151935889.html Biology Fri, 23 Jan 2009 12:25:21 EST news151935889 A research group from Costa Rican evaluated risk factors for gastric cancer in Costa Rican regions with contrasting gastric cancer incidence rates (GCIR). They found that although a pro-inflammatory cytokine genetic profile showed an increased risk for developing gastric cancer (GC), the characteristics of Helicobacter pylori (H. pylori) infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. http://www.physorg.com/news151755622.html Medicine & Health Wed, 21 Jan 2009 10:20:42 EST news151755622 A research group from Sweden investigated the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Helicobacter pylori (H. pylori). They found that the H. pylori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways. http://www.physorg.com/news151754929.html Medicine & Health Wed, 21 Jan 2009 10:09:20 EST news151754929 Bacteria that cause stomach ulcers and cancer could also be giving us bad breath, according to research published in the December issue of the Journal of Medical Microbiology. For the first time, scientists have found Helicobacter pylori living in the mouths of people who are not showing signs of stomach disease. http://www.physorg.com/news146723056.html Biology Mon, 24 Nov 2008 04:24:16 EST news146723056 A multi-center research team, led by Columbia University Medical Center, has uncovered a major contributor to the cause of stomach cancer - the second leading cause of cancer-related mortality in the world. The team described for the first time, that elevated levels of a single proinflammatory cytokine, an immune system protein called interleukin-1 beta (IL-1β), can start the progression towards stomach cancer. These results are published in the Nov. 4, 2008 issue of Cancer Cell. The researchers hope to use this finding to develop ways to block this process, thereby preventing cancer from developing. http://www.physorg.com/news145109406.html Medicine & Health Wed, 05 Nov 2008 12:10:06 EST news145109406 Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature. These bacteria, which are called Helicobacter pylori, live in the stomachs of humans. http://www.physorg.com/news142481521.html Medicine & Health Mon, 06 Oct 2008 03:12:01 EST news142481521 Three RND efflux systems had been identified in H pylori, namely hefABC, hefDEF, and hefGHI, each of which consisted of a translocase, an accessory protein. But the contribution of efflux proteins to antibiotic resistance is not well established. 27 putative translocases also had been identified in the H pylori 26695 genome, but only four putative H pylori OEPs or TolC homologs were identified. While they could not quantitate the operons expression levels of the efflux systems in multidrug resistance strains of H pylori. http://www.physorg.com/news141037915.html Medicine & Health Fri, 19 Sep 2008 10:11:55 EST news141037915 Helicobacter pylori lipopolysaccharide, the major virulent factor of H. pylori, triggers interleukin-8 production in gastric epithelia through activating Toll-like receptor 4 pathways, leading to gastric mucosal inflammation. A research team in China demonstrated that Lactobacillus bulgaricus decreased H. pylori Sydney strain 1 lipopolysaccharide-induced interleukin-8 production through inhibiting the activation of Toll-like receptor 4. http://www.physorg.com/news140240976.html Medicine & Health Wed, 10 Sep 2008 04:49:36 EST news140240976 Researchers have uncovered a big clue as to why some of the bacteria that cause stomach ulcers pose a greater risk for serious problems like stomach cancer than others; it turns out these bacteria can exploit the surrounding stomach cells to protect them from the immune system. http://www.physorg.com/news138625242.html Medicine & Health Fri, 22 Aug 2008 12:00:42 EST news138625242 Remnants of the bacterium that causes stomach ulcers, Helicobacter pylori, (H. pylori) have been discovered in gastric tissue from North American mummies. A study of human remains believed to predate Columbus' discovery of the New World has shown for the first time that H. pylori infection occurred in native populations, according to research published in BioMed Central's open access journal, BMC Microbiology. http://www.physorg.com/news135319352.html Biology Tue, 15 Jul 2008 05:42:32 EST news135319352