http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors. http://www.physorg.com/news177359577.html Medicine & Health Fri, 13 Nov 2009 18:50:02 EST news177359577 When it comes to plants' innate immunity, like many of the dances of life, it takes two to tango. A receptor molecule in the plant pairs up with a specific molecule on the invading bacteria and, presto, the immune system swings into action to defend against the invasion of the disease-causing microbe. http://www.physorg.com/news176655045.html Biology Thu, 05 Nov 2009 14:55:27 EST news176655045 (PhysOrg.com) -- Federal stimulus funding helps Cornell researchers create tiny 3-D models of tumors to mimic conditions necessary for the development of vascular systems by tumors. http://www.physorg.com/news176456604.html Medicine & Health Tue, 03 Nov 2009 08:50:02 EST news176456604 Researchers at UT Southwestern Medical Center have eliminated non-small cell lung (NSCL) cancer in mice by using an investigative drug called BEZ235 in combination with low-dose radiation. http://www.physorg.com/news176033624.html Medicine & Health Thu, 29 Oct 2009 11:14:18 EST news176033624 (PhysOrg.com) -- Results from comprehensive assessments of diabetes' effects on cell metabolism may aid efforts to reduce diabetic damage to nerves, blood vessels and other tissues, according to researchers at Washington University School of Medicine in St. Louis and elsewhere. http://www.physorg.com/news175418901.html Medicine & Health Thu, 22 Oct 2009 08:40:01 EST news175418901 Virginia Commonwealth University researchers have identified the role of a gene in regulating molecular signals involved with ovarian follicle development, which may one day help shed light on some of the causes of fertility issues in humans. http://www.physorg.com/news173712184.html Biology Fri, 02 Oct 2009 14:40:01 EST news173712184 An international team of scientists has discovered a new way to classify stomach cancers, and researchers say it may be an important step toward designing more effective treatments and improving long-term survival. http://www.physorg.com/news173681833.html Medicine & Health Fri, 02 Oct 2009 06:20:02 EST news173681833 (PhysOrg.com) -- Gavin Robertson is not a man who uses the word ‘hate` lightly, but he makes no secret of his desire to slay the dragon that is malignant melanoma. http://www.physorg.com/news173464661.html Medicine & Health Tue, 29 Sep 2009 17:42:08 EST news173464661 Using state-of-the-art electron microscopy techniques, a team led by researchers from Caltech has for the first time visualized and described the precise arrangement of chemoreceptors -the receptors that sense and respond to chemical stimuli -in bacteria. In addition, they have found that this specific architecture is the same throughout a wide variety of bacterial species, which means that this is a stable, universal structure that has been conserved over evolutionary time. http://www.physorg.com/news173024669.html Biology Thu, 24 Sep 2009 15:25:42 EST news173024669 Amputations trigger a molecular response that determines if a head or tail will be regrown in planaria, a flatworm commonly studied for its regenerative capabilities. Until now, no molecular connection between wounding and the decision to regenerate either a head or tail in planaria had been identified. http://www.physorg.com/news172162137.html Medicine & Health Mon, 14 Sep 2009 16:20:02 EST news172162137 (PhysOrg.com) -- Researchers at the Carnegie Institution's Department of Plant Biology have discovered a key missing link in the so-called signaling pathway for plant steroid hormones (brassinosteroids). Many important signaling pathways are relays of molecules that start at the cell surface and cascade to the nucleus to regulate genes. http://www.physorg.com/news171644021.html Biology Tue, 08 Sep 2009 15:54:12 EST news171644021 Use of the molecularly targeted agent lapatinib to delay tumor growth and improve the survival of patients with inoperable hepatocellular carcinoma, or liver cancer, only benefited certain subgroups of patients. While results of this study were largely negative, patients that exhibited toxicity from the drug in the form of a skin rash appeared to have a greater tumor response and longer survival. http://www.physorg.com/news171636490.html Medicine & Health Tue, 08 Sep 2009 14:10:02 EST news171636490 Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and researchers at Washington University School of Medicine in St. Louis now think they know why. http://www.physorg.com/news170136373.html Medicine & Health Sat, 22 Aug 2009 05:07:15 EST news170136373 The deadliest part of the cancer process, metastasis, appears to rely on help from macrophages, potent immune system cells that usually defend vigorously against disease, researchers at Albert Einstein College of Medicine of Yeshiva University report. http://www.physorg.com/news169150129.html Medicine & Health Mon, 10 Aug 2009 19:20:01 EST news169150129 Investigators at the Burnham Institute for Medical Research (Burnham) and The Scripps Research Institute (TSRI) have made the first comparative, large-scale phosphoproteomic analysis of human embryonic stem cells (hESCs) and their differentiated derivatives. The data may help stem cell researchers understand the mechanisms that determine whether stem cells divide or differentiate, what types of cells they become and how to control those complex mechanisms to facilitate development of new therapies. The study was published in the August 6 issue of the journal Cell Stem Cell. http://www.physorg.com/news168786097.html Biology Thu, 06 Aug 2009 14:02:00 EST news168786097 Infectious-disease specialists at UT Southwestern Medical Center have demonstrated that a cannibalistic process in cells plays a key role in limiting Salmonella infection. http://www.physorg.com/news168538515.html Medicine & Health Mon, 03 Aug 2009 17:15:55 EST news168538515 (PhysOrg.com) -- A UCLA study has identified a way to turn off a key signaling pathway involved in physiological processes that can also stimulate the development of cancer and other diseases. The findings may lead to new treatments and targeted drugs using this approach. http://www.physorg.com/news167314425.html Medicine & Health Mon, 20 Jul 2009 13:30:01 EST news167314425 Patients who survive an initial diagnosis of breast cancer often succumb to the disease years later when the cancer shows up in a different part of the body. Now, scientists have identified key signals that support the long term survival of breast cancer cells after they have spread to the bone marrow. The research, published by Cell Press in the July issue of the journal Cancer Cell, may lead to development of treatment strategies that decrease the likelihood of breast cancer recurrence in the bone and other organs. http://www.physorg.com/news166104644.html Medicine & Health Mon, 06 Jul 2009 13:11:20 EST news166104644 In a study with important consequences for studies on the effects of chemicals on steroid responses in humans, a team of French and American scientists, including Michael E. Baker, PhD, professor in UC San Diego's Department of Medicine, Division of Nephrology-Hypertension, have found that - contrary to earlier assumptions - enzymes used for the synthesis of steroids in insects, snails, octopuses and corals are unrelated to those used in humans. http://www.physorg.com/news165516684.html Medicine & Health Mon, 29 Jun 2009 18:40:02 EST news165516684 Differences in growth factor (GF) signaling may cause the poor prognosis in some breast cancer cases. A new study, published in the open access journal BMC Medical Genomics, suggests that some estrogen receptor-positive breast cancers respond poorly to tamoxifen because of increased GF signaling. http://www.physorg.com/news165005770.html Medicine & Health Wed, 24 Jun 2009 04:00:01 EST news165005770 (June 21, 2009) - Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans. In an article that appears in the current issue of Nature Cell Biology, researchers at Baylor College of Medicine report that a new finding about the Notch signaling pathway in sensory organ precursor cells in the fruit fly could explain the mystery behind an immunological disorder called Wiskott-Aldrich syndrome. http://www.physorg.com/news164809934.html Biology Sun, 21 Jun 2009 14:10:02 EST news164809934 No signal has been heard from distress beacons on a missing Air France plane, indicating it suffered a "very rapid" catastrophe, a top French space agency official told AFP on Monday. http://www.physorg.com/news163084420.html Technology Mon, 01 Jun 2009 14:14:07 EST news163084420 A team of neuroscientists at Cold Spring Harbor Laboratory (CSHL) has demonstrated the mechanism by which a signaling protein found throughout the brain controls the maturation and strength of excitatory synapses, the tiny gaps across which the majority of neurons communicate. http://www.physorg.com/news163077382.html Medicine & Health Mon, 01 Jun 2009 12:16:54 EST news163077382 It is the concentration of a few signaling molecules that determines the fate of individual cells during the early development of organisms. In the renowned journal Current Biology, a team of molecular biologists led by Pia Aanstad of the University of Innsbruck reports that a variety of molecular mechanisms accounts for the interpretation of the concentration of the signaling molecule Hedgehog. http://www.physorg.com/news162215335.html Biology Fri, 22 May 2009 12:49:30 EST news162215335 An international study led by Ohio State University neuroscience researchers describes one of the missing triggers that controls calcium inside cells, a process important for muscle contraction, nerve-cell transmission, insulin release and other essential functions. http://www.physorg.com/news159625171.html Medicine & Health Wed, 22 Apr 2009 13:20:13 EST news159625171 A new study reveals the importance of adenylylation in the regulation of cell signaling from bacteria to higher organisms. The research, published by Cell Press in the April 10th issue of the journal Molecular Cell, provides new insight into bacterial pathogenesis and opens intriguing avenues for exploring post-translational modifications in eukaryotic cells. http://www.physorg.com/news158503513.html Biology Thu, 09 Apr 2009 13:45:33 EST news158503513 Scientists have developed a new approach for surveying phosphorylation, a process that is regulated by critical cell signaling pathways and regulates several key cellular signaling events. The research, published by Cell Press in the April 10th issue of the journal Molecular Cell, describes the regulation of a previously uncharacterized protein and demonstrates that it plays an important role in cancer cell invasion. http://www.physorg.com/news158502443.html Medicine & Health Thu, 09 Apr 2009 13:27:55 EST news158502443 It's basically a given that diets loaded with fat can lead to considerable health problems. But a new study in the April issue of Cell Metabolism, a Cell Press publication, shows that in some cases diets that are high in both fat and protein can be even worse. http://www.physorg.com/news158328667.html Biology Tue, 07 Apr 2009 13:11:35 EST news158328667 Scientists used to think most of the exchange of information between cells was conducted at the surface, where cell receptors receive signals from other cells. http://www.physorg.com/news156711582.html Medicine & Health Thu, 19 Mar 2009 20:00:38 EST news156711582 A novel signaling pathway plays a significant role in the production of aldosterone, a hormone that promotes heart failure after a myocardial infarction, according to a study conducted by Thomas Jefferson University researchers. http://www.physorg.com/news156450714.html Medicine & Health Mon, 16 Mar 2009 19:32:26 EST news156450714