http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Finding molecules that block the activity of the oncogene Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, said a Baylor College of Medicine researcher in a report that appears in the current online issue of the journal PLoS One (Public Library of Science ONE). http://www.physorg.com/news155938280.html Medicine & Health Tue, 10 Mar 2009 21:11:39 EST news155938280 (PhysOrg.com) -- Researchers have achieved a feat drug developers had thought difficult, if not impossible, discovering a compound that blocks the functioning of a key developmental protein by binding to an `undruggable` target - an advance that may provide a new avenue to fight skin, pancreatic, prostate, and other cancers. http://www.physorg.com/news151594160.html Biology Mon, 19 Jan 2009 13:29:57 EST news151594160 (PhysOrg.com) -- In 1913 Theodore Roosevelt added cartographer to his resume when he and his crew ventured up an unspeakably dangerous and uncharted tributary named the River of Doubt. Now, on a charting expedition of their own, Rockefeller University scientists have completed a journey that has also defied expectation. In work to be published in the January 9 issue of Cell, the team reports the discovery of a new family of receptors in the fly nose, a finding that not only fills in a missing piece in the organizational logic of the insect olfactory system but also unearths one of the most ancient mechanisms that organisms have evolved to smell. http://www.physorg.com/news150640317.html Biology Thu, 08 Jan 2009 12:31:57 EST news150640317 Aging yeast cells accumulate damage over time, but they do so by following a pattern laid down earlier in their life by diet as well as the genes that control metabolism and the dynamics of cell structures such as mitochondria, the power plants of cells. http://www.physorg.com/news148658925.html Biology Tue, 16 Dec 2008 14:08:45 EST news148658925 (PhysOrg.com) -- University of Arizona researchers are among a group of scientists who have discovered a source of previously scarce small RNA molecules. Their finding, which was recently published in the Proceedings of the National Academy of Sciences, provides a valuable new tool for better understanding how plants grow and develop. http://www.physorg.com/news145817480.html Biology Thu, 13 Nov 2008 16:51:20 EST news145817480 In the study, the scientists screened known drugs and identified small molecules that could replace conventional reprogramming genes, which can have dangerous side effects. This new process offers a new way to generate stem cells from fibroblasts, a general cell type that is abundant and easily accessible from various tissues, including skin. http://www.physorg.com/news145108757.html Biology Wed, 05 Nov 2008 11:59:17 EST news145108757 Scientists at The Wistar Institute and their colleagues have identified, for the first time, a molecule that can regulate microRNAs - short strands of RNA that play a vital role in gene expression and are closely associated with cancer. The discovery points the way to the development of a new generation of cancer drugs. http://www.physorg.com/news141565967.html Chemistry Thu, 25 Sep 2008 12:52:47 EST news141565967