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(PhysOrg.com) -- Despite commercial availability and direct to consumer marketing of a new genetic test designed to reveal a breast cancer patient`s sensitivity to tamoxifen, most physicians in the U.S. are not currently using it to guide treatment, according to research from Duke University Medical Center presented today at the CTRC-AACR San Antonio Breast Cancer Symposium. http://www.physorg.com/news179765658.html Medicine & Health Fri, 11 Dec 2009 15:10:10 EST news179765658 Chemotherapy generally improves survival in postmenopausal breast cancer patients, according to a landmark study led by Dr. Kathy Albain of Loyola University Health System. http://www.physorg.com/news179737360.html Medicine & Health Fri, 11 Dec 2009 07:04:22 EST news179737360 Even when women at high-risk of breast cancer are well-informed about the risks and benefits of using the drug tamoxifen for prevention, only 6 percent said they were likely to take it. http://www.physorg.com/news179051911.html Medicine & Health Thu, 03 Dec 2009 09:00:01 EST news179051911 Researchers have found evidence of a statistically significant survival benefit from adjuvant tamoxifen among patients whose estrogen receptor (ER)-positive tumors had high levels of phosphorylation of ER-alpha; at serine-118 (ER-alpha S118-P), according to a brief communication published online November 25 in the Journal of the National Cancer Institute. http://www.physorg.com/news178393693.html Medicine & Health Wed, 25 Nov 2009 19:50:01 EST news178393693 Among women with early stage breast cancer, genetic variation of a certain enzyme appears to be associated with clinical outcomes for women treated with tamoxifen, according to a study in the October 7 issue of JAMA. http://www.physorg.com/news174065071.html Medicine & Health Tue, 06 Oct 2009 16:40:17 EST news174065071 The largest study in the world of treatments for post menopausal, hormone positive breast cancer has shown that patients who continue to take exemestane or tamoxifen do significantly better than patients who start to take one or other drug (or tamoxifen followed exemestane) but then stop. http://www.physorg.com/news172819061.html Medicine & Health Tue, 22 Sep 2009 10:20:01 EST news172819061 New research has found that switching post-menopausal women with early breast cancer to the drug exemestane (Aromasin) after two or three years of tamoxifen rather than keeping them on tamoxifen for five years improves the chance of remaining cancer free and reduces the risk of death for at least the next six years. http://www.physorg.com/news172779638.html Medicine & Health Mon, 21 Sep 2009 20:00:01 EST news172779638 While long-term tamoxifen use among breast cancer survivors decreases their risk of developing the most common, less aggressive type of second breast cancer, such use is associated with a more than four-fold increased risk of a more aggressive, difficult-to-treat type of cancer in the breast opposite, or contralateral, to the initial tumor. These findings by Christopher Li, M.D., Ph.D., and colleagues at Fred Hutchinson Cancer Research Center were published online Aug. 25 in the journal Cancer Research. http://www.physorg.com/news170427487.html Medicine & Health Tue, 25 Aug 2009 13:58:43 EST news170427487 An FDA-approved drug used for preventing recurrence of breast cancer shows promise in fighting life-threatening fungal infections common in immune-compromised patients, such as infants born prematurely and patients with cancer. Some scientists suspected that tamoxifen has antifungal properties; now new research from the University of Rochester Medical Center shows that it actually kills fungus cells and stops them from causing disease. http://www.physorg.com/news167310214.html Medicine & Health Mon, 20 Jul 2009 12:03:56 EST news167310214 (AP) -- Breast cancer survivors risk having their disease come back if they use certain antidepressants while also taking the cancer prevention drug tamoxifen, worrisome new research shows. http://www.physorg.com/news162995769.html Medicine & Health Sun, 31 May 2009 13:37:02 EST news162995769 Breast cancer cells in the laboratory that don't respond to tamoxifen may be producing high amounts of cholesterol in order to provide a kind of shield against the drug, say researchers at Georgetown University Medical Center (GUMC). http://www.physorg.com/news159464522.html Medicine & Health Mon, 20 Apr 2009 16:42:31 EST news159464522 Goserelin, a lutenizing hormone-releasing hormone agonist, reduces the long-term risk of disease recurrence and deaths in premenopausal women with early breast cancer who did not take tamoxifen, according to trial data reported in the February 24 online issue of the Journal of the National Cancer Institute. http://www.physorg.com/news154720614.html Medicine & Health Tue, 24 Feb 2009 17:57:24 EST news154720614 Two separate meta-analyses of clinical trials from around the world that tested tamoxifen against aromatase inhibitor drugs in postmenopausal women with early breast cancer have each reached the same conclusion: aromatase inhibitors are more effective in preventing breast cancer from coming back. Patients using aromatase inhibitors had more than a 3 percent lower cancer recurrence 6-8 years after diagnosis, compared to women using tamoxifen alone. http://www.physorg.com/news148236483.html Medicine & Health Thu, 11 Dec 2008 16:48:03 EST news148236483 Mayo Clinic researchers have discovered that a chemical known as endoxifen appears to be the primary metabolite responsible for the effectiveness of tamoxifen in treating breast cancer, and that it works against cancer in an entirely unexpected way. http://www.physorg.com/news148225168.html Medicine & Health Thu, 11 Dec 2008 13:39:28 EST news148225168 Tamoxifen may worsen breast cancer in a small subset of patients. Research published in BioMed Central's open access journal Breast Cancer Research suggests that in patients who show reduced or absent expression of the protein E-cadherin, commonly used anti-oestrogen drugs such as tamoxifen may promote more harmful cancer cell behaviour. http://www.physorg.com/news147587111.html Medicine & Health Thu, 04 Dec 2008 04:25:11 EST news147587111 Researchers at Georgetown University Medical Center have discovered a novel way in which breast cancer cells become resistant to tamoxifen, the world's largest-selling breast cancer prevention and treatment drug. They say the findings could provide a way to identify tamoxifen users who are no longer benefiting from the drug, allowing doctors to try another therapy option sooner. http://www.physorg.com/news144564961.html Medicine & Health Thu, 30 Oct 2008 05:56:01 EST news144564961 The drug tamoxifen does not prevent or treat estrogen receptor (ER) negative breast cancer, but it can make the disease easier to find, researchers report in the Oct. 1 Journal of the National Cancer Institute. http://www.physorg.com/news142613381.html Medicine & Health Tue, 07 Oct 2008 15:49:41 EST news142613381