http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- Two genes containing mutations known to cause rare familial forms of parkinsonism are also associated with the more common, sporadic form of the disease where there is no family history, researchers have found. http://www.physorg.com/news177683398.html Medicine & Health Tue, 17 Nov 2009 13:00:03 EST news177683398 A new class of molecules capable of blocking the formation of specific protein clumps that are believed to contribute to Alzheimer's disease pathology has been discovered by researchers at the University of Pennsylvania School of Medicine. By assaying close to 300,000 compounds, they have identified drug-like inhibitors of AD tau protein clumping, as reported in the journal Biochemistry. http://www.physorg.com/news169132024.html Chemistry Mon, 10 Aug 2009 15:00:01 EST news169132024 New insights into how a Phase III Alzheimer's drug might work were among the advances in potential therapies targeting two abnormal brain proteins - beta amyloid and phosphorylated tau - that were reported today at the Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD 2009) in Vienna. http://www.physorg.com/news166867134.html Medicine & Health Wed, 15 Jul 2009 08:59:17 EST news166867134 (PhysOrg.com) -- A discovery made by researchers at McGill University and the affiliated Lady Davis Research Institute for Medical Research at Montreal's Jewish General Hospital offers new hope for the early diagnosis and treatment of Alzheimer's disease. http://www.physorg.com/news162210645.html Chemistry Fri, 22 May 2009 11:31:53 EST news162210645 Researchers at the University of Illinois at Chicago College of Medicine have discovered a mode of action for mysterious but diagnostic protein snarls found in the brains of Alzheimer's patients that suggests a one-two punch of therapy may be needed to combat the neurodegenerative disease. http://www.physorg.com/news156528664.html Medicine & Health Tue, 17 Mar 2009 17:11:33 EST news156528664 A test capable of confirming or ruling out Alzheimer's disease has been validated and standardized by researchers at the University of Pennsylvania School of Medicine. By measuring cerebrospinal fluid (CSF) concentrations of two of the disease's biochemical hallmarks - amyloid beta42 peptide and tau protein - the test also predicted whether a person's mild cognitive impairment would convert to Alzheimer's disease over time. Researchers were able to detect this devastating disease at the earliest stages, before dementia symptoms appeared and widespread irreversible damage occurred. The findings hold promise in the search for effective pharmaceutical therapies capable of halting the disease. http://www.physorg.com/news156435142.html Medicine & Health Mon, 16 Mar 2009 15:13:05 EST news156435142 (PhysOrg.com) -- Which modules of the tau protein, in neurons of Alzheimer disease patients, may act in a destructive manner were investigated by researchers from the Max Planck Institute for Biophysical Chemistry (Göttingen) and the Max Planck Unit for Structural Molecular Biology (Hamburg) with the help of Nuclear Magnetic Resonance Spectroscopy. http://www.physorg.com/news154107548.html Biology Tue, 17 Feb 2009 15:39:42 EST news154107548 Scientists at UC Santa Barbara have discovered that a protein called BAG2 is important for understanding Alzheimer's disease and may open up new targets for drug discovery. They are ready to move from studying these proteins in culture to finding out how they work with mice. http://www.physorg.com/news153062159.html Medicine & Health Thu, 05 Feb 2009 13:16:37 EST news153062159 Expression of the microtubule-binding protein Tau is not a reliable means of selecting breast cancer patients for adjuvant paclitaxel chemotherapy, according to research led by The University of Texas M. D. Anderson Cancer Center. http://www.physorg.com/news148453038.html Medicine & Health Sun, 14 Dec 2008 04:57:18 EST news148453038 MIT engineers report a new approach to identifying protein structures key to Alzheimer's disease, an important step toward the development of new drugs that could prevent such structures from forming. http://www.physorg.com/news138591482.html Medicine & Health Fri, 22 Aug 2008 02:38:02 EST news138591482 New research suggests that a select group of compounds that interact with a protein in the brain might be used in the early diagnosis and treatment of Alzheimer's disease and other dementia disorders. http://www.physorg.com/news138534992.html Medicine & Health Thu, 21 Aug 2008 10:56:32 EST news138534992