http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. Having partnered last year with an international team that surveyed the genomes of 12,000 individuals to find a genetic cause for gout, Johns Hopkins scientists now have shown that the malfunctioning gene they helped uncover can lead to high concentrations of blood urate that forms crystals in joint tissue, causing inflammation and pain - the hallmark of this disease. http://www.physorg.com/news164593887.html Medicine & Health Fri, 19 Jun 2009 01:32:15 EST news164593887 A gene mutation that causes high levels of uric acid in all Dalmatian dogs and bladder stones in some Dalmatians, has been identified by a team of researchers in the School of Veterinary Medicine at the University of California, Davis. http://www.physorg.com/news145254651.html Biology Fri, 07 Nov 2008 04:30:51 EST news145254651 A team of researchers from the United States and the Netherlands has identified mutations in three genes that are associated with high levels of uric acid in the blood, which is a risk factor for gout. The team developed a genetic risk score composed of the number of uric acid-increasing mutations that each person carries (0 to 6), which was associated with up to a 40-fold increased risk for developing gout when comparing persons at lowest and highest risk. The findings are published in the October 4 issue of The Lancet. http://www.physorg.com/news142227709.html Medicine & Health Fri, 03 Oct 2008 04:41:49 EST news142227709 Researchers have identified two new genes - and confirmed the role of a third gene - associated with increased risk of higher levels of uric acid in the blood, which can lead to gout, a common, painful form of arthritis. Combined, the three genetic variations were associated with up to a 40-fold increased risk in developing gout. The findings suggest that genetic testing could one day be used to identify individuals at risk for gout before symptoms develop, as well as determine who might benefit from medications to prevent the development of gout. http://www.physorg.com/news142052419.html Medicine & Health Wed, 01 Oct 2008 04:00:19 EST news142052419 Elevated uric acid levels in the blood indicate an increased risk of new-onset kidney disease, according to a study appearing in the December 2008 issue of the Journal of the American Society Nephrology (JASN). The results suggest that it may be appropriate to prescribe uric acid -lowering drugs, such as allopurinol and probenecid, to these otherwise healthy individuals. http://www.physorg.com/news140891428.html Medicine & Health Wed, 17 Sep 2008 17:30:28 EST news140891428 (PhysOrg.com) -- A new drug designed to normalize levels of uric acid in the blood appears to be safe and tolerable and may help patients with the painful arthritic condition known as gout better cope with their disease, say researchers at Duke University Medical Center. http://www.physorg.com/news139584356.html Medicine & Health Tue, 02 Sep 2008 14:25:56 EST news139584356 The drug allopurinol, which lowers uric acid levels, appears to reduce blood pressure in adolescents with newly diagnosed hypertension, according to a preliminary report in the August 27 issue of JAMA. http://www.physorg.com/news138989149.html Medicine & Health Tue, 26 Aug 2008 17:05:49 EST news138989149 Reducing levels of uric acid in blood lowered blood pressure to normal in most teens in a study designed to investigate a possible link between blood pressure and the chemical, a waste product of the body's normal metabolism, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of the American Medical Association. http://www.physorg.com/news138988460.html Medicine & Health Tue, 26 Aug 2008 16:54:20 EST news138988460