http://www.physorg.com/ en-us Physorg.com internet news portal provides the latest news on science including: Physics, Nanotechnology, Life Sciences, Space Science, Earth Science, Environment, Health and Medicine. (PhysOrg.com) -- A preclinical study found a new nasal spray vaccine to provide complete protection against a major botulism toxin, according to a study published today in the Nature journal Gene Therapy. http://www.physorg.com/news150731070.html Medicine & Health Fri, 09 Jan 2009 13:44:30 EST news150731070 Commonly used pneumococcal polysaccharide vaccines do not appear to be effective for preventing pneumonia, found a study by a team of researchers from Switzerland and the United Kingdom. http://www.physorg.com/news150397463.html Medicine & Health Mon, 05 Jan 2009 17:04:23 EST news150397463 Research led by Johns Hopkins Children's Center scientists has figured out why a respiratory syncytial virus vaccine used in 1966 to inoculate children against the infection instead caused severe respiratory disease and effectively stopped efforts to make a better one. The findings, published online on Dec. 14 in Nature Medicine, could restart work on effective killed-virus vaccines not only for RSV but other respiratory viruses, researchers say. The new findings also debunk a popular theory that the 1966 vaccine was ineffective because the formalin used to inactivate the virus disrupted critical antigens, the substances that stimulate the production of protective antibodies. http://www.physorg.com/news148577725.html Medicine & Health Mon, 15 Dec 2008 15:35:25 EST news148577725 Research out of the Ireland Cancer Center of University Hospitals Case Medical Center has found that the vast majority of triple negative breast cancers express the MUC-1 target. This first-of-its-kind finding, presented today at the San Antonio Breast Cancer Symposium, has paved the way for an upcoming vaccine trial for patients with early stage triple negative breast cancer that could potentially prevent recurrence of this aggressive type of breast cancer. http://www.physorg.com/news148315876.html Medicine & Health Fri, 12 Dec 2008 14:51:16 EST news148315876 Individuals younger than 50 who have been previously vaccinated do not appear to have a substantially different immune response to a half-dose of influenza vaccine than to a full dose, according to a report in the December 8/22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. This suggests that half-dose vaccination in healthy young individuals may be effective in times of vaccine shortage. http://www.physorg.com/news147980207.html Medicine & Health Mon, 08 Dec 2008 17:36:47 EST news147980207 Results published online today in the New England Journal of Medicine revealed that the world's most clinically advanced malaria vaccine candidate provides both infants and young children with significant protection against malaria. Two separate phase II trials reaffirmed earlier study results and support the ongoing efforts, pending regulatory approvals, to launch the phase III study of GlaxoSmithKline (GSK) Biologicals' RTS,S/AS vaccine candidate across Africa. http://www.physorg.com/news147960934.html Medicine & Health Mon, 08 Dec 2008 12:15:34 EST news147960934 One fifth of the standard dose of a commonly used meningitis vaccine may be as effective as using the full dose. This new finding should allow scarce vaccine resources to be stretched further, especially during epidemics in Africa. http://www.physorg.com/news147697933.html Medicine & Health Fri, 05 Dec 2008 11:12:13 EST news147697933 Hypersensitivity reactions to the quadrivalent HPV vaccine (4vHPV, Gardasil) are uncommon and most schoolgirls can tolerate subsequent doses, finds the first evaluation of the quadrivalent HPV vaccine published on bmj.com today. http://www.physorg.com/news147505857.html Medicine & Health Wed, 03 Dec 2008 05:50:57 EST news147505857 Most successful vaccines and drugs rely on protecting humans or animals by blocking certain bacteria from growing in their systems. But, a new theory actually hopes to take stopping infectious diseases such as West Nile virus and Malaria to the next level by disabling insects from transmitting these viruses. Research to be presented at the 57th American Society of Tropical Medicine and Hygiene (ASTMH) annual meeting in New Orleans, explains how vaccines and drugs may not only be able to stop disease transmission, but also prematurely kill the vectors carrying these diseases; such vectors include ticks, sand flies and mosquitoes - the insects responsible for most deaths world wide. http://www.physorg.com/news147463549.html Medicine & Health Tue, 02 Dec 2008 18:05:49 EST news147463549 A partial dose of a commonly used vaccine against meningitis may be as effective as a full dose, according to new research published December 2 in the open-access journal PLoS Neglected Tropical Diseases. Fractional dosing would enable large-scale vaccination campaigns during epidemics, especially at a time of global vaccine shortages. http://www.physorg.com/news147443831.html Medicine & Health Tue, 02 Dec 2008 12:37:11 EST news147443831 Although naturally occurring smallpox was eradicated in 1977, there is concern that bioterrorists might obtain smallpox from a laboratory and release it into the population. Under such circumstances, the supply of smallpox vaccine may be insufficient for universal administration. In a study published in the December 2008 issue of The American Journal of Medicine, researchers found that lifetime protection is obtained from just one vaccination, even when that vaccination occurred as much as 88 years ago. They conclude that in the event of a smallpox bioterrorist attack, vaccinia smallpox vaccine should be used first on individuals who have not been vaccinated previously. http://www.physorg.com/news147337295.html Medicine & Health Mon, 01 Dec 2008 07:01:35 EST news147337295 In the first study of its kind, researchers at the Yerkes National Primate Research Center and Emory Vaccine Center, Emory University, have developed a multidisciplinary approach involving immunology, genomics and bioinformatics to predict the immunity of a vaccine without exposing individuals to infection. This approach addresses a long-standing challenge in the development of vaccines--that of only being able to determine immunity or effectiveness long after vaccination and, often, only after being exposed to infection. http://www.physorg.com/news146667030.html Medicine & Health Sun, 23 Nov 2008 12:50:30 EST news146667030 Despite recent doubts about its effectiveness, the influenza vaccine does give valuable protection against illness, hospital admission and death caused by influenza, and people over 65 should have the flu jab this winter, say experts on bmj.com today. http://www.physorg.com/news146297434.html Medicine & Health Wed, 19 Nov 2008 06:10:34 EST news146297434 Results from the Step study, a test-of-concept efficacy study of a Merck & Co., Inc. HIV vaccine candidate, were published online today in two papers in The Lancet. These analyses of the Step study are being conducted, presented and published to inform the continued search for an effective HIV vaccine. http://www.physorg.com/news145773261.html Medicine & Health Thu, 13 Nov 2008 04:34:21 EST news145773261 (PhysOrg.com) -- The advance towards a vaccine for HIV/AIDS has taken another step closer to realization. A vaccine, developed by Dr. Chil-Yong Kang and his team at the Schulich School of Medicine & Dentistry at The University of Western Ontario, and licensed to Sumagen Canada Inc., has now been manufactured for use in trials - first, in toxicology trials using animal models and then in Phase 1 human clinical trials. The vaccine has been manufactured at a bio-safety level 3 (BSL3) good manufacturing practice (GMP) facility in the United States. http://www.physorg.com/news145722346.html Medicine & Health Wed, 12 Nov 2008 14:25:46 EST news145722346 The question of whether or not to continue to pursue the development of T-cell-based HIV-1 vaccines has been a source of controversy following last year's widely publicized failure of the field's most promising candidate, a vaccine developed by Merck known as V520. http://www.physorg.com/news145458791.html Medicine & Health Sun, 09 Nov 2008 13:13:11 EST news145458791 In September 2007, a phase II HIV-1 vaccine trial was abruptly halted when researchers found that the vaccine may have promoted, rather than prevented, HIV infection. A new study by a team of researchers at the Montpellier Institute of Molecular Genetics in France shows how the vaccine could have enhanced HIV infection. The study, lead by Matthieu Perreau, will be published online on November 3 of the Journal of Experimental Medicine. http://www.physorg.com/news144928118.html Medicine & Health Mon, 03 Nov 2008 09:48:38 EST news144928118 A new study by researchers at Wake Forest University School of Medicine and Vanderbilt University suggests that protecting infants from a common, highly contagious and even deadly disease may be as easy as administering a routine vaccine two weeks earlier than it is typically given. http://www.physorg.com/news144912497.html Medicine & Health Mon, 03 Nov 2008 05:28:17 EST news144912497 Children who receive all recommended flu vaccine appear to be less likely to catch the respiratory virus that the CDC estimates hospitalizes 20,000 children every year. http://www.physorg.com/news144912406.html Medicine & Health Mon, 03 Nov 2008 05:26:46 EST news144912406 This month, Pakistan is introducing a new combination vaccine that will protect its children against the bacterium Haemophilus influenzae type b (Hib) and four other common childhood diseases. http://www.physorg.com/news144769980.html Medicine & Health Sat, 01 Nov 2008 14:53:00 EST news144769980 A single administration of a novel, nasally delivered influenza vaccine elicited immune responses in ferrets that were more than 20 times higher than those generated by two injections of the currently approved vaccines, according to a study by NanoBio Corporation. The new vaccine used only half the standard antigen dose to produce this effect. http://www.physorg.com/news144422552.html Medicine & Health Tue, 28 Oct 2008 14:22:32 EST news144422552 Despite the government's decision to choose the vaccine Cervarix for the UK human papillomavirus (HPV) vaccination programme, every doctor I have spoken to has chosen Gardisal for their own children, says a doctor on bmj.com today. http://www.physorg.com/news144044779.html Medicine & Health Fri, 24 Oct 2008 05:26:19 EST news144044779 UCLA scientists engineered a new tuberculosis (TB) vaccine specifically designed for HIV-positive people that was shown to be safer and more potent than the current TB vaccine in preclinical trials. http://www.physorg.com/news143979160.html Medicine & Health Thu, 23 Oct 2008 11:12:40 EST news143979160 (PhysOrg.com) -- Doctors have always hoped that scientists might one day create a vaccination that would treat a broad spectrum of maladies. They could only imagine that there might be one vaccine that would protect against, say, 2,500 strains of Salmonella. And what if that same vaccine could help protect the elderly? http://www.physorg.com/news143811145.html Medicine & Health Tue, 21 Oct 2008 12:32:25 EST news143811145 Researchers are one step closer to finding a vaccine that better protects against tuberculosis. An investigational vaccine for TB tested at Saint Louis University appears likely to offer significantly better protection against the potentially fatal disease than the one in current use. http://www.physorg.com/news143692721.html Medicine & Health Mon, 20 Oct 2008 03:38:41 EST news143692721 A single vaccine could be used to protect chickens, cats and humans against deadly flu pandemics, according to an article published in the November issue of the Journal of General Virology. The vaccine protects birds and mammals against different flu strains and can even be given to birds while they are still in their eggs, allowing the mass vaccination of wild birds. http://www.physorg.com/news143691774.html Biology Mon, 20 Oct 2008 03:22:54 EST news143691774 A recently introduced polio vaccine is four times more effective at protecting children than previous vaccines and has the potential to eradicate type 1 polio in Nigeria if it reaches enough children, according to a study published today in the New England Journal of Medicine. http://www.physorg.com/news143307449.html Medicine & Health Wed, 15 Oct 2008 16:37:29 EST news143307449 An international study led by University of Leicester researchers has determined that vaccination will be the best way to protect people in the event of the next influenza pandemic - but that each person would need two doses. http://www.physorg.com/news142703150.html Medicine & Health Wed, 08 Oct 2008 16:45:50 EST news142703150 Researchers at Aberystwyth University, following a number of years of investment by the Biotechnology and Biological Sciences Research Council (BBSRC), have licensed ground-breaking research to a non-profit product development partnership working to develop new, more effective vaccines against Tuberculosis (TB). This development will give hope that significantly better prevention and treatment of TB will be available within the next few years. http://www.physorg.com/news142654588.html Medicine & Health Wed, 08 Oct 2008 03:16:28 EST news142654588 Pneumococcal (pneumonia) vaccination was associated with a 50% lower risk of heart attacks 2 years after vaccination, suggests a large hospital-based case-control study published in CMAJ. http://www.physorg.com/news142565443.html Medicine & Health Tue, 07 Oct 2008 02:30:43 EST news142565443