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Search results for burnham institute for medical research
Unraveling how cells respond to low oxygen
Aug 05, 2009 |
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Gary Chiang, Ph.D., and colleagues at Burnham Institute for Medical Research (Burnham) have elucidated how the stability of the REDD1 protein is regulated. The REDD1 protein is a critical inhibitor of the mTOR signaling pathway, ...
When proteins change partners
Sep 11, 2009 |
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Dieter Wolf, M.D., and colleagues at Burnham Institute for Medical Research (Burnham) have illuminated how competition between proteins enhances combinatorial diversity during ubiquitination (the process that marks proteins ...
Researchers illuminate mechanisms that regulate DNA damage control and replication
Biology /
Jan 05, 2009 |
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Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating ...
Stem cell research uncovers mechanism for type 2 diabetes
Feb 12, 2009 |
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Taking clues from their stem cell research, investigators at the University of California San Diego (UC San Diego) and Burnham Institute for Medical Research (Burnham) have discovered that a signaling pathway involved in ...
MicroRNAs help control HIV life cycle
Jun 25, 2009 |
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Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, ...
The path to new antibiotics: Researchers find vulnerable enzyme in pathogens
Aug 27, 2009 |
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Researchers at Burnham Institute for Medical Research (Burnham), University of Texas Southwestern Medical Center and University of Maryland have demonstrated that an enzyme that is essential to many bacteria can be targeted ...
Scientists develop method for comprehensive proteome analysis
Apr 08, 2009 |
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Investigators at Burnham Institute for Medical Research (Burnham) have deciphered a large percentage of the total protein complement (proteome) in Schizosaccharomyces pombe (S. pombe) fission yeast.
Creating ideal neural cells for clinical use
Apr 13, 2009 |
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Investigators at the Burnham Institute for Medical Research (Burnham) have developed a protocol to rapidly differentiate human embryonic stem cells (hESCs) into neural progenitor cells that may be ideal for transplantation. ...
New insights into limb formation
Aug 12, 2009 |
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Investigators at Burnham Institute for Medical Research (Burnham) and the University of Connecticut Health Center (U.C.H.C.) have gained new understanding of the role hyaluronic acid (HA) plays in skeletal growth, chondrocyte ...
Researchers discover 'on switch' for cell death signaling mechanism
Biology /
Jan 05, 2009 |
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Scientists at Burnham Institute for Medical Research (Burnham) have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex (DISC), which is responsible for ...
Carbohydrate acts as tumor suppressor
Jul 06, 2009 |
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Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These ...
Delivering medicine directly into a tumor
Dec 07, 2009 |
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Researchers at Burnham Institute for Medical Research at University of California, Santa Barbara have identified a peptide (a chain of amino acids) that specifically recognizes and penetrates cancerous tumors but not normal ...
Researchers turn cancer friend into cancer foe
Oct 07, 2008 |
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Burnham Institute for Medical Research today announced that scientists have created a peptide that binds to Bcl-2, a protein that protects cancer cells from programmed cell death, and converts it into a cancer cell killer. ...
How proteins talk to each other: Caspase-3 cleaves in unforeseen ways
Sep 21, 2009 |
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Investigators at Burnham Institute for Medical Research have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). Using an advanced proteomic technique called ...
Device protects transplanted pancreatic cells from the immune system
Apr 09, 2009 |
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Scientists at Burnham Institute for Medical Research (Burnham) and the University of California San Diego (UC San Diego) School of Medicine have demonstrated in mice that transplanted pancreatic precursor cells are protected ...
