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Getting more from whole-transcript microarrays
May 21, 2009 |
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The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing. Research published today in the ...
Molecular Therapy for Spinal Muscular Atrophy Closer to Clinical Use
Dec 15, 2008 |
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(PhysOrg.com) -- Spinal muscular atrophy, a neurodegenerative disorder that causes the weakening of muscles, is the leading cause of infant death and occurs in 1 in 6,000 live births. While trans-splicing (a form of molecular ...
Gene Expression and Splicing Vary Widely from One Tissue to the Next
Biology /
Dec 23, 2008 |
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(PhysOrg.com) -- Genes talk to themselves and to each other to control how a given cell manufactures proteins. But variation in the control of the same gene in two different tissues may contribute to certain human traits, ...
Siestas Among the Drosophilae
Biology /
Jan 28, 2009 |
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(PhysOrg.com) -- Isaac Edery is concerned with biological clocks, internal mechanisms that enable virtually all plants and animals to behave in rhythmic biological cycles known as circadian rhythms.
Study finds new relationship between gene duplication and alternative splicing in plants
Dec 07, 2009 |
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University of Georgia scientists looking to understand the genetic mechanisms of plant defense and growth have found for the first time in plants an inverse relationship between gene duplication and alternative ...
Scientists devise potential approach to treat spinal muscular atrophy
Apr 05, 2008 |
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In the neuromuscular disease called spinal muscular atrophy, or SMA, a protein deficiency caused by a single gene mutation leads to serious damage in growing nerve cells and the muscles they control.
University of Toronto finds humans and chimps differ at level of gene splicing
Biology /
Nov 14, 2007 |
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Researchers are closer to understanding why humans differ so greatly from chimpanzees in the way they look, behave, think, and fight off disease, despite having genes that are nearly 99% identical.
Deep sequencing study reveals new insights into human transcriptome
Biology /
Jul 08, 2008 |
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In a collaborative project scientists from the Max-Planck-Institute for Molecular Genetics in Berlin (MPI MolGen), Germany and Genomatix with a business in Munich, Germany and Ann Arbor, MI, USA, applied next generation sequencing ...
Researchers identify drug candidate for treating spinal muscular atrophy
Nov 04, 2009 |
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A chemical cousin of the common antibiotic tetracycline might be useful in treating spinal muscular atrophy (SMA), a currently incurable disease that is the leading genetic cause of death in infants. This is the finding of ...
Study reveals intermediary steps of genetic encoding for the first time
Mar 27, 2009 |
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In a new study this week in Nature, researchers at Brandeis University and the MRC Laboratory of Molecular Biology (Cambridge, U.K.) for the first time shed light on a crucial step in the complex process by which human geneti ...
Alternative splicing proteins prompt heart development
Dec 08, 2008 |
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Just as the emotions it represents are dynamic, the heart's development requires dynamic shifts in proteins that prompt alternative spicing, a mechanism that allows a given gene to program the cell to make several proteins, ...
Yale scientists visualize the machinery of mRNA splicing
Biology /
Apr 05, 2008 |
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Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our genomes; it illuminated a relationship between gene processing in humans and the most primitive organisms by creating ...
Unravelling new complexity in the genome
Biology /
Aug 13, 2007 |
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A major surprise emerging from genome sequencing projects is that humans have a comparable number of protein-coding genes as significantly less complex organisms such as the minute nematode worm Caenorhabditis elegans. Clearly ...
Gene mutation linked to cognition is found only in humans
Biology /
May 08, 2007 |
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The human and chimpanzee genomes vary by just 1.2 percent, yet there is a considerable difference in the mental and linguistic capabilities between the two species. A new study showed that a certain form of neuropsin, a protein ...
Researchers identify protein controlling brain formation
Sep 04, 2009 |
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Researchers at the University of Toronto have identified a protein which plays a key role in the development of neurons, which could enhance our understanding of how the brain works, and how diseases such as Alzheimer's occur.
