Search results for hif 1
Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction
May 22, 2009 |
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A protein that plays a key role in tumor formation, oxygen metabolism and inflammation is involved in a pathway that extends lifespan by dietary restriction. The finding, which appears in the May 22, 2009 edition of the ...
Researchers found a way to treat ischemic pathologies
Aug 05, 2009 |
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A team of researchers from CIC bioGUNE, Spain, alongside a team from Paris' Cardiovascular Research Centre (INSERM U970) have developed a new area of research which looks extremely promising as regards the development of ...
Bioengineered proteins: Trial confirms new way to tackle cancer
Mar 26, 2009 |
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Re-engineering a protein that helps prevent tumours spreading and growing has created a potentially powerful therapy for people with many different types of cancer. In a study published in the first issue of EMBO Molecular Me ...
How chemotherapy drugs block blood vessel growth, slow cancer spread
Jan 22, 2009 |
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Researchers at the Johns Hopkins University School of Medicine have discovered how a whole class of commonly used chemotherapy drugs can block cancer growth. Their findings, reported online this week at the Proceedings of ...
Link between chronic kidney disease and oxygen-deprived tissue
Dec 18, 2007 |
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Researchers at the University of Pennsylvania School of Medicine have discovered how low-oxygen conditions can worsen chronic kidney disease (CKD). The key player is a protein called hypoxia-inducible-factor (HIF-1) that, ...
New hope for cancer comes straight from the heart
Jan 05, 2009 |
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Digitalis-based drugs like digoxin have been used for centuries to treat patients with irregular heart rhythms and heart failure and are still in use today. In the Dec. 16 issue of the Proceedings of the National Academy of ...
New way to combat cancer
Nov 14, 2006 |
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In many forms of cancer the tumor encounters a lack of oxygen, a condition that the tumor tries to prevent in various ways. A research group with its base at Lund University in Sweden is now presenting findings that may make ...
1930s drug slows tumor growth
Medicine & Health / Medications
Nov 06, 2009 |
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Drugs sometimes have beneficial side effects. A glaucoma treatment causes luscious eyelashes. A blood pressure drug also aids those with a rare genetic disease. The newest surprise discovered by researchers at the Johns ...
Reversing effects of altered enzyme may fight brain tumor growth
Apr 14, 2009 |
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An international team of scientists from the Moores Cancer Center at the University of California, San Diego, the University of North Carolina and several institutions in China have explained how a gene alteration can lead ...
Gene therapy and stem cells save limb
Dec 08, 2009 |
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Blood vessel blockage, a common condition in old age or diabetes, leads to low blood flow and results in low oxygen, which can kill cells and tissues. Such blockages can require amputation resulting in loss of limbs. Now, ...
Hormone links sleep, hunger and metabolism, researchers find
Nov 14, 2007 |
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While investigating how the hormone orexin might control sleep and hunger, researchers at UT Southwestern Medical Center have discovered, to their surprise, that it activates a protein, HIF-1, long known to stimulate cancerous ...
Survival mode that protects cells when oxygen is low also slows aging (w/Video)
Apr 16, 2009 |
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A biochemical pathway that helps keep cells alive when oxygen is low also plays a role in longevity and resistance against some diseases of old age, according to a report to be published April 16 in the journal ...
Lower levels of key protein influence tumor growth in mice, study shows
Jun 01, 2009 |
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Tumors need a healthy supply of blood to grow and spread. Researchers at the Stanford University School of Medicine have identified a molecule that regulates blood vessel growth that is often found at less-than-normal levels ...
Researchers Link Master Regulator of Innate Immunity to the Hypoxic Response
Biology /
Apr 23, 2008 |
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Survival of all animals depends on their ability to withstand microbial infections and adapt to fluctuations in oxygen concentrations. These abilities depend on two ancient, evolutionary gene expression responses called the ...
HFI-1 gene has key role in both oxygen sensing, heat shock pathway
Oct 25, 2006 |
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University of Oregon researchers have found an unexpected regulatory link between cellular responses to hypoxia and heat shock. Central to the discovery is a gene known as Hypoxia-Inducible Factor-1 (HIF-1) that is critical ...
