Search results for mitotic checkpoint
Death, division or cancer? Newly discovered checkpoint process holds the line in cell division
Jul 01, 2008 |
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Each day, a staggering number of cells perform a feat that still amazes researchers with its complexity: they divide to produce perfect replicas of each other. The process is called mitosis, and an inability to control it ...
A breakthrough in gastric carcinogenesis
Jun 11, 2009 |
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Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to ...
Stem-cell sentry sounds the alarm to maintain balance between cancer and aging
Oct 15, 2008 |
5 / 5 (8) |
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(PhysOrg.com) -- Like a sentry guarding the castle walls, a molecular messenger inside adult stem cells sounds the alarm when it senses hazards that could allow the invasion of an insidious enemy: Cancer. The alarm bell halts ...
New research shows key player in mitosis not required for chromosome alignment
Jul 06, 2009 |
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(PhysOrg.com) -- K-fibers, structures long thought to play a key role in the alignment of chromosomes prior to cell division, are not required after all, say Indiana University and New York State Department ...
How chemo kills tumours: research to reduce side effects
Aug 01, 2008 |
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(PhysOrg.com) -- University of Manchester researchers are investigating exactly how chemotherapy drugs kill cancerous tumours in a bid to reduce side effects and test the effectiveness of safer new agents.
Lack of CHFR gene expression sets stage for breast cancer
Jun 19, 2008 |
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[B]U-M study lays groundwork for better ways to choose effective treatments, provides insights on other cancers[/B] A University of Michigan study reveals in detail how breast cells produce new cells tha ...
Researchers unveil vital key to cancer
Aug 06, 2008 |
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University of Manchester scientists have uncovered the 3-D structure of Mps1 -- a protein that regulates the number of chromosomes during cell division and thus has an essential role in the prevention of cancer -- which will ...
Researchers work out the mechanics of asymmetric cell division
Biology /
May 03, 2007 |
4.3 / 5 (3) |
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When a cell divides, normally the result is two identical daughter cells. In some cases however, cell division leads to two cells with different properties. This is called asymmetric cell division and plays an important role ...
New step in DNA damage response in neurons discovered
Biology /
Jan 18, 2009 |
5 / 5 (3) |
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Researchers have identified a biochemical switch required for nerve cells to respond to DNA damage. The finding, scheduled for advance online publication in Nature Cell Biology, illuminates a connection between proteins involv ...
One-dimensional Diffusion Accelerates Molecular Motors
Biology /
May 12, 2006 |
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Max Planck scientists have identified a new strategy which motor proteins use to move. The research was carried out by Prof. Jonathon Howard and Stefan Diez at the Max Planck Institute of Molecular Cell Biology ...
Aurora B answers an XIST-ential question
Aug 24, 2009 |
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Early in development, mammalian female cells counteract their double dose of X chromosomes by coating one of them with a large RNA named XIST. The RNA binds to the same X chromosome from which it is transcribed ...
Cell division studies hint at future cancer therapy
Biology /
Jan 22, 2008 |
4.7 / 5 (3) |
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When a cell’s assets get divided between daughter cells, Dr. Quansheng Du wants to make sure both offspring do well.
Slicing chromosomes leads to new insights into cell division
May 29, 2009 |
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(PhysOrg.com) -- By using ultrafast laser pulses to slice off pieces of chromosomes and observe how the chromosomes behave, biomedical engineers at the University of Michigan have gained pivotal insights into mitosis, the ...
Key factor in brain development revealed, offers insight into disorder
Mar 26, 2008 |
4.8 / 5 (4) |
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In the earliest days of brain development, the brain’s first cells – neuroepithelial stem cells -- divide continuously, producing a population of cells that eventually evolves into the various cells of the fully formed brain. ...
New way of inhibiting cell cycle shows promise
Oct 22, 2008 |
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Geneva, Switzerland: A new anti-cancer compound that works by blocking a part of the cell's machinery that is crucial for cell division has shown promising results in a phase I clinical trial in patients who have failed to ...
