Search results for mutant mitochondrial:
Large reservoir of mitochondrial DNA mutations identified in humans
Aug 11, 2008 |
4.6 / 5 (20) |
5
Researchers at the University of Newcastle, England, and the Virginia Bioinformatics Institute at Virginia Tech in the United States have revealed a large reservoir of mitochondrial DNA mutations present in the general population. ...
Mitochondrial 'bottleneck' cracked
Jan 27, 2008 |
4.3 / 5 (23) |
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Scientists have shown for the first time how a particular family of diseases are passed down from mother to child and how this can lead to the severity of the disease differing widely. The research, funded by the Wellcome ...
Mitochondrial DNA mutations can cause degenerative heart and muscle disease
Feb 14, 2008 |
4.1 / 5 (11) |
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A single change in the DNA of mitochondria – the cellular power plants that generate energy in all human cells – has been found to cause degenerative heart and muscle disease, according to University of California, Irvine ...
Role for CISD2 gene in human disease and lifespan control
May 15, 2009 |
4.5 / 5 (2) |
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In the May 15th issue of G&D, Dr. Ting-Fen Tsai (The National Yang-Ming University, Taiwan) and colleagues present a new animal model of human Wolfram Syndrome, and effectively link CISD2 gene function, mitochondrial integr ...
Chemopreventive isothiocyanates selectively depletes mutant p53 in tumor cells
Apr 20, 2009 |
5 / 5 (1) |
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Researchers at Lombardi Comprehensive Cancer Center at Georgetown University Medical Center have demonstrated that naturally-occurring compounds can selectively deplete mutant p53 and restore "wild type" function to p53 in ...
Forget the antioxidants? Researchers cast doubt on role of free radicals in aging
Biology /
Feb 17, 2009 |
4.5 / 5 (10) |
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For more than 40 years, the prevailing explanation of why we get old has been tied to what is called oxidative stress. This theory postulates that when molecules like free radicals, oxygen ions and peroxides build up in cells, ...
Mutant gene's true effect revealed - giving new therapy hope
Oct 19, 2009 |
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(PhysOrg.com) -- Scientists have revealed how a mutant gene that causes a connective tissue disease resulting in dwarfism does so by significantly affecting the inside of cells - opening up new therapy strategies that involve ...
Modification of mutant huntingtin protein increases its clearance from brain cells
Apr 02, 2009 |
5 / 5 (2) |
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A new study has identified a potential strategy for removing the abnormal protein that causes Huntington's disease (HD) from brain cells, which could slow the progression of the devastating neurological disorder. In the ...
New hope for treatment of neurodegenerative disorder
Apr 20, 2009 |
5 / 5 (1) |
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Researchers from the University of Southern California have taken an important first step toward protecting against Huntington disease using gene therapy.
Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
Medicine & Health / Neuroscience
Jun 19, 2009 |
not rated yet |
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A Japanese research group, led by Dr. Yoko Yamagata of the National Institute for Physiological Sciences, has successfully generated a novel kinase-dead mutant mouse of the CaMKIIalpha gene that completely and exclusively ...
Scientists Discover New Way of Selectively Killing Cancer Cells
Biology /
Mar 26, 2008 |
4.4 / 5 (15) |
1
A Columbia University professor has discovered a chemical mechanism that can selectively kill cancer cells while leaving normal cells unharmed. Brent R. Stockwell, an associate professor in the department ...
Researchers identify new, cancer-causing role for protein
Aug 27, 2009 |
5 / 5 (2) |
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The mainstay immune system protein TRAF6 plays an unexpected, key role activating a cell signaling molecule that in mutant form is associated with cancer growth, researchers at The University of Texas M. D. ...
Gene may 'bypass' disease-linked mitochondrial defects, fly study suggests
May 05, 2009 |
5 / 5 (1) |
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By lending them a gene normally reserved for other classes of animals, researchers have shown they can rescue flies from their Parkinson's-like symptoms, including movement defects and excess free radicals produced in power-generating ...
Metabolic disorder underlies Huntington's disease
Oct 19, 2006 |
3.7 / 5 (3) |
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A metabolic disorder underlies the brain effects found in those with Huntington's disease, researchers report in an advance article publishing online October 19, 2006. The article will appear in the November 2006 issue of ...
Nerve Cells' Power Plants Caught In A Traffic Jam
Aug 03, 2005 |
1.5 / 5 (2) |
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Nerve cells need lots of energy to work properly, and the energy needs to be delivered to the right place at the right time. By inducing a mutation in fruit flies, researchers have figured out that a particular ...
