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LMNA-deficient Animals

Lamin A/C deficiency is 'unnerving'

Biology /

created Jan 05, 2009 | popularity 3 / 5 (1) | comments 0

Mutations in the nuclear intermediate filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. Méjat et al. show that one mechanism ...


Researchers construct a device that mimics one of nature’s key transport machines

Researchers construct a device that mimics one of nature's key transport machines

Biology /

created Jan 06, 2009 | popularity 4.7 / 5 (7) | comments 0

(PhysOrg.com) -- To help protect its genes, a cell is highly selective about what it allows to move in and out of its nucleus. Yet that choosiness is regulated by just a thin barrier, perforated with tiny ...


Location matters, even for genes

Medicine & Health / Genetics

created Feb 13, 2008 | popularity not rated yet | comments 0

Moving an active gene from the interior of the nucleus to its periphery can inactivate that gene report scientists from the University of Chicago Medical Center in an article to be published early online Feb.13, 2008, in ...


Come on in: Nuclear barrier less restrictive than expected in new cells

Chemistry / Biochemistry

created Oct 06, 2009 | popularity not rated yet | comments 0

When it comes to the two basic types of cells, prokaryotes and eukaryotes, compartmentalization is everything. Prokaryotes are evolutionarily ancient cells that only have a membrane surrounding their outer boundary, while ...


Molecular machine turns packaged messenger RNA into a linear transcript

Biology /

created Feb 11, 2009 | popularity 5 / 5 (1) | comments 0

For RNA, the gateway to a productive life outside the nucleus is the nuclear pore complex, an amalgamation of 30 kinds of proteins that regulates all traffic passing through the nuclear membrane. New research from Rockefeller ...


Molecular bridge serves as a tether for a cell's nucleus

Molecular bridge serves as a tether for a cell's nucleus

Biology /

created Aug 08, 2008 | popularity 4.8 / 5 (14) | comments 1

(PhysOrg.com) -- A cell's nucleus - home of it its most precious contents — is a delicate envelope that, without support, is barely able to withstand the forces that keep it in place. Now, researchers have ...


A flying carpet might take us to Pluto

Space & Earth /

created Apr 26, 2006 | popularity 3.2 / 5 (12) | comments 0

A U.S. scientist says a giant solar panel unfurled in space like a carpet might one day make space flights possible without using nuclear propulsion.


Research identifies 3-D structure of key nuclear pore building block

Biology / Cell & Microbiology

created Jun 07, 2009 | popularity 5 / 5 (1) | comments 0

The genome of complex organisms is stashed away inside each cell's nucleus, a little like a sovereign shielded from the threatening world outside. The genome cannot govern from its protective chamber, however, without knowing ...


Chromosomes dance and pair up on the nuclear membrane

Chromosomes dance and pair up on the nuclear membrane (w/ Video)

Biology / Cell & Microbiology

created Nov 13, 2009 | popularity 4.7 / 5 (3) | comments 0

(PhysOrg.com) -- Meiosis - the pairing and recombination of chromosomes, followed by segregation of half to each egg or sperm cell - is a major crossroads in all organisms reproducing sexually. Yet, how the ...


Groundbreaking discovery may lead to stronger antibiotics

Biology /

created Oct 01, 2008 | popularity 4.4 / 5 (16) | comments 1

The last decade has seen a dramatic decline in the effectiveness of antibiotics, resulting in a mounting public health crisis across the world. A new breakthrough by University of Virginia researchers provides physicians ...


Crystal structure enables tailoring of pharmaceuticals against asthma

Medicine & Health / Diseases

created Jul 16, 2007 | popularity 3 / 5 (1) | comments 0

Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein – LTC4 synthase – which has a major influence on the development of asthma. LTC4 synthase is extremely ...


Structural study backs new model for the nuclear pore complex

Structural study backs new model for the nuclear pore complex

Biology /

created Dec 24, 2008 | popularity 4.5 / 5 (2) | comments 0

(PhysOrg.com) -- In higher organisms, the genetic material is confined and protected in the cell nucleus. In order for a healthy cell to function, the DNA must send manufacturing orders through the double ...


Research suggests core nuclear pore elements shared by all eukaryotes

Chemistry / Biochemistry

created Jul 13, 2009 | popularity 5 / 5 (1) | comments 0

(PhysOrg.com) -- For perhaps 1.8 billion years after life first emerged on Earth, a sort of evolutionary writer’s block stalled the development of organisms more complicated than single cells. Then, a burst of experimental ...


Structural biology scores with protein snapshot

Structural biology scores with protein snapshot

Biology / Cell & Microbiology

created Jun 25, 2009 | popularity 5 / 5 (1) | comments 0

In a landmark technical achievement, investigators in the Vanderbilt Center for Structural Biology have used nuclear magnetic resonance (NMR) methods to determine the structure of the largest membrane-spanning ...


Biologists reveal structure of cell nucleus 'gatekeeper'

Biologists reveal structure of cell nucleus 'gatekeeper'

Biology / Cell & Microbiology

created Oct 27, 2009 | popularity 4 / 5 (5) | comments 6

(PhysOrg.com) -- Biologists led by associate professor Thomas Schwartz (MIT) have worked out a rudimentary architectural plan for the nuclear pore complex (NPC), the gatekeeper of the cell's nucleus.